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Article
Dynamin-related protein 1 mediates the therapeutic effect of isoliquiritigenin in diabetic intimal hyperplasia via regulation of mitochondrial fission
Phenotypic shift of vascular smooth muscle cells (VSMCs) plays a key role in intimal hyperplasia, especially in patients with diabetes mellitus (DM). This study aimed to investigate the role of dynamin-related...
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Article
Rare earth modified reduced graphene oxide reinforced AgCuTi composite brazing filler for brazing C/C composites
In order to solve the formation of brittle compounds in brazed joints, an innovative rare earth modified reduced graphene oxide reinforced AgCuTi composite brazing filler was designed to achieve brazed joints ...
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Article
Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages
Ulcerative colitis (UC) is associated with changed dietary habits and mainly linked with the gut microbiota dysbiosis, necroptosis of epithelial cells, and mucosal ulcerations. Liver dysfunction and abnormal l...
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Article
Open AccessOTUB1/NDUFS2 axis promotes pancreatic tumorigenesis through protecting against mitochondrial cell death
Pancreatic cancer is one of the most fatal cancers in the world. A growing number of studies have begun to demonstrate that mitochondria play a key role in tumorigenesis. Our previous study reveals that NDUFS2 (N...
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Article
Cpd-A1 alleviates acute kidney injury by inhibiting ferroptosis
Acute kidney injury (AKI) is defined as sudden loss of renal function characterized by increased serum creatinine levels and reduced urinary output with a duration of 7 days. Ferroptosis, an iron-dependent reg...
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Article
On the Factors Influencing the High Stretch–Flangeability of a Low-Density 1180 MPa Fe–Mn–Al–C–Nb δ-QP Steel
Low-density δ-quenching and partitioning (δ-QP) steels with excellent strength and ductility have been recently developed. However, there are still rare reports on the formability of δ-QP steels, which are cri...
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Article
Open AccessMicrobial communities modulate chemical weathering and carbon dioxide cycling in an active orogen in Taiwan
Chemical weathering modulates carbon transfer between the crust, hydrosphere, and atmosphere. The extent to which microbial processes are involved in mineral dissolution remains elusive. Here, we performed geo...
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Article
Relationships between bilateral auditory brainstem activity and inter-implant interval in children with cochlear implants
To investigate the effect of the interval between bilateral cochlear implantation on the development of bilateral peripheral auditory pathways as revealed by the electrically evoked auditory brainstem response...
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Article
SMAD4 endows TGF-β1-induced highly invasive tumor cells with ferroptosis vulnerability in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy prone to recurrence and metastasis. Studies show that tumor cells with increased invasive and metastatic potential are more likely ...
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Article
Open AccessGenetic basis of nectar guide trichome variation between bumblebee- and self-pollinated monkeyflowers (Mimulus): role of the MIXTA-like gene GUIDELESS
Nectar guide trichomes play crucial ecological roles in bee-pollinated flowers, as they serve as footholds and guides for foraging bees to access the floral rewards. However, the genetic basis of natural varia...
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Article
Open AccessEffectiveness and mechanism of action of rTMS combined with quadriceps strength training in individuals with knee osteoarthritis: study protocol for a randomized controlled trial
Quadriceps training is necessary in function and activity of daily living for patients with knee osteoarthritis (KOA). However, it did not reduce the rate of surgical treatment for end-stage KOA in the long te...
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Article
Species diversity, updated classification and divergence times of the phylum Mucoromycota
Zygomycetes are phylogenetically early diverging, ecologically diverse, industrially valuable, agriculturally beneficial, and clinically pathogenic fungi. Although new phyla and subphyla have been constantly e...
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Article
Open AccessA new glance at autophagolysosomal-dependent or -independent function of transcriptional factor EB in human cancer
Autophagy-lysosome system plays a variety of roles in human cancers. In addition to being implicated in metabolism, it is also involved in tumor immunity, remodeling the tumor microenvironment, vascular prolif...
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Article
Prediction of sintered density of binary W(Mo) alloys using machine learning
Powder metallurgy is the optimal method for the consolidation and preparation of W(Mo) alloys, which exhibit excellent application prospects at high temperatures. The properties of W(Mo) alloys are closely rel...
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Article
Singular Equivalences Induced by Bimodules and Quadratic Monomial Algebras
We investigate the problem when the tensor functor by a bimodule yields a singular equivalence. It turns out that this problem is equivalent to the one when the Hom functor given by the same bimodule induces a...
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Article
Open AccessHernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway
Hernandezine (Her) is a bisbenzylisoquinoline alkaloid extracted from the traditional Chinese herbal medicine Thalictrum glandulosissimum. Evidence shows that Her is a natural agonist of adenosine monophosphate (...
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Article
Open AccessToripalimab combined with lenvatinib and GEMOX is a promising regimen as first-line treatment for advanced intrahepatic cholangiocarcinoma: a single-center, single-arm, phase 2 study
Advanced intrahepatic cholangiocarcinoma (ICC) has a dismal prognosis. Here, we report the efficacy and safety of combining toripalimab, lenvatinib, and gemcitabine plus oxaliplatin (GEMOX) as first-line thera...
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Article
Open AccessConcurrence of immune thrombocytopenic purpura and thrombotic thrombocytopenic purpura: a case report and review of the literature
Immune thrombocytopenic purpura and thrombotic thrombocytopenic purpura are both causes of thrombocytopenia. Recognizing thrombotic thrombocytopenic purpura is crucial for subsequent treatment and prognosis. I...
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Article
Open AccessImplementing a novel capture and ligation probe-PCR method in mass screen and treatment to support malaria elimination efforts in the China-Myanmar border region
Mass screening and treatment (MSAT) for malaria elimination lacks an ideal diagnostic tool to allow sensitive and affordable test of the target population in the field. This study evaluated whether Capture and...
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Chapter and Conference Paper
Research and Practice on the Integration of High-Efficiency Reserves Increase and Productivity Construction by Dominant Sedimentary Facies-Structure Coupling: A Case Study of E3s1 on Qinan Slope
High-efficiency blocks of Z42, Z5 and Z68 have been successively found on Qinan slope, which proves the potential of the target area. No breakthrough was made after several rounds of exploration and evaluation...
