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Article
Elimination of cracks in stainless steel casings via 3D printed sand molds with an internal topology structure
The important supporting component in a gas turbine is the casing, which has the characteristics of large size, complex structure, and thin wall. In the context of existing 3DP sand casting processes, casting ...
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Article
Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor
Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, ...
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Article
Open AccessA novel efficient strategy to generate liver sinusoidal endothelial cells from human pluripotent stem cells
Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells (ECs) that play an important role in liver development and regeneration. Additionally, it is involved in various pathological...
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Article
Therapeutic effects and mechanisms of isoxanthohumol on DSS-induced colitis: regulating T cell development, restoring gut microbiota, and improving metabolic disorders
Ulcerative colitis (UC) is a severe hazard to human health. Since pathogenesis of UC is still unclear, current therapy for UC treatment is far from optimal. Isoxanthohumol (IXN), a prenylflavonoid from hops an...
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Article
Open AccessLink Brain-Wide Projectome to Neuronal Dynamics in the Mouse Brain
Knowledge about the neuronal dynamics and the projectome are both essential for understanding how the neuronal network functions in concert. However, it remains challenging to obtain the neural activity and th...
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Article
Identification of CD5/SOX11 double-negative pleomorphic mantle cell lymphoma
Cyclin D1 protein-positive diffuse large B cell lymphoma (DLBCL) has an immunophenotype of CD5(−) cyclin D1(+) SOX11(−), and most cases lack a CCND1 rearrangement and have a gene expression profile of DLBCL. Rare...
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Article
Geriatric nutrition risk index: a more powerful index identifying muscle mass loss in patients with rheumatoid arthritis
To explore the association of geriatric nutrition risk index (GNRI), a traditional albumin-body weight calculation, with myopenia in patients with rheumatoid arthritis (RA) and compare its ability to identify ...
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Article
Artificial neural network-based method for discriminating Compton scattering events in high-purity germanium γ-ray spectrometer
To detect radioactive substances with low activity levels, an anticoincidence detector and a high-purity germanium (HPGe) detector are typically used simultaneously to suppress Compton scattering background, t...
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Article
Open AccessTuning polymer-backbone coplanarity and conformational order to achieve high-performance printed all-polymer solar cells
All-polymer solar cells (all-PSCs) offer improved morphological and mechanical stability compared with those containing small-molecule-acceptors (SMAs). They can be processed with a broader range of conditions...
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Article
Photobiomodulation Increases M2-Type Polarization of Macrophages by Inhibiting Versican Production After Spinal Cord Injury
Spinal cord injury (SCI) is a catastrophic accidence with little effective treatment, and inflammation played an important role in that. Previous studies showed photobiomodulation (PBM) could effectively downr...
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Article
Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids
A strong correlation between gut microbes and host health has been observed in numerous gut metagenomic cohort studies. However, the underlying mechanisms governing host–microbe interactions in the gut remain ...
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Article
Open AccessSystemic inflammation and insulin resistance-related indicator predicts poor outcome in patients with cancer cachexia
The C-reactive protein (CRP)-triglyceride-glucose (TyG) index (CTI), which is a measure representing the level of inflammation and insulin resistance (IR), is related to poor cancer prognosis; however, the CTI...
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Article
Open AccessCombining pathological risk factors and T, N staging to optimize the assessment for risk stratification and prognostication in low-risk stage III colon cancer
This study aimed to investigate the combined pathological risk factors (PRFs) to stratify low-risk (pT1-3N1) stage III colon cancer (CC), providing a basis for individualized treatment in the future.
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Article
Divergent defluorocarboxylation of α-CF3 alkenes with formate via photocatalyzed selective mono- or triple C-F bond cleavage
Unprecedented divergent synthesis of gem-difluorovinylacetic acid and glutaric acid derivatives from α-CF3 alkenes with formate as the carbonyl source was disclosed. The reaction can undergo selective mono- or tr...
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Article
Soil pH differently affects N2O emissions from soils amended with chemical fertilizer and manure by modifying nitrification and denitrification in wheat-maize rotation system
Emissions of nitrous oxide (N2O), a potent greenhouse gas, from farmland have been recognized to be affected by soil pH and nitrogen (N) fertilizer application. However, the interactive effects of soil pH and N f...
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Article
Open AccessAbnormal expression of PRKAG2-AS results in dysfunction of cardiomyocytes through regulating PRKAG2 transcription by interacting with PPARG
The role of PRKAG2 in the maintenance of heart function is well established, but little is known about how PRKAG2 is regulated in cardiomyocytes. In this study, we investigated the role of the lncRNA PRKAG2-AS, w...
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Article
Review of the development status of rock burst disaster prevention system in China
Deep-land resource exploitation is a crucial focus of future scientific and technological development in China. However, with the increasing depth of coal mining, rock burst disasters occur frequently, posing ...
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Article
Open AccessCD24+LCN2+ liver progenitor cells in ductular reaction contributed to macrophage inflammatory responses in chronic liver injury
CD24+CK19+/CD24+SOX9+ resident liver cells are activated and expanded after chronic liver injury in a ductular reaction. However, the sources and functions of these cells in liver damage remain disputed.
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Article
Progress in Preparation and Properties of Porous Silicon Nitride Ceramics
Porous silicon nitride ceramics is a promising functional ceramic material. In recent years, the research on the preparation of porous silicon nitride ceramics within different methods has been widely investig...
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Article
Open AccessSodium nitroprusside improved the quality of Radix Saposhnikoviae through constructed physiological response under ecological stress
The ecological significance of secondary metabolites is to improve the adaptive ability of plants. Secondary metabolites, usually medicinal ingredients, are triggered by unsuitable environment, thus the qualit...
