20 Result(s)

Article

Over-production of nitric oxide by oxidative stress-induced activation of the TGF-β1/PI3K/Akt pathway in mesangial cells cultured in high glucose

To investigate whether NO over-production in rat mesangial cells cultured in high glucose (HG) is related to activation of the TGF-β1/PI3K/Akt pathway.

Yun-peng Zhai, Qian Lu, Yao-wu Liu, Qian Cheng, Ya-qin Wei… in Acta Pharmacologica Sinica (2013)

Article

Ethanol extract of propolis protects macrophages from oxidized low density lipoprotein-induced apoptosis by inhibiting CD36 expression and endoplasmic reticulum stress-C/EBP homologous protein pathway

Ethanol extract of propolis (EEP), rich in flavones, has been known for various biological activities including antioxidant, antiinflammatory and antibiotic activities. Our previous studies have shown that EEP...

Hua Tian, Hong-Wei Sun, Jia-Jun Zhang… in BMC Complementary and Alternative Medicine (2015)

Article

A comprehensive study of long-term skeletal changes after spinal cord injury in adult rats

Spinal cord injury (SCI)-induced bone loss represents the most severe osteoporosis with no effective treatment. Past animal studies have focused primarily on long bones at the acute stage using adolescent rode...

Tiao Lin, Wei Tong, Abhishek Chandra, Shao-Yun Hsu, Haoruo Jia, Ji Zhu… in Bone Research (2015)

Article

AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation

Patients with stage II or III colorectal cancer (CRC) exhibit various clinical outcomes after radical treatments. The 5-year survival rate was between 50 and 87%. However, the underlying mechanisms of the vari...

Ying-Nan Wang, Yun-**n Lu, Jie Liu, Ying **, Hui-Chang Bi, Qi Zhao… in Oncogene (2020)

Article

Role of the PPAR pathway in atrial fibrillation associated with heart valve disease: transcriptomics and proteomics in human atrial tissue

Huan-**n Chen, Ming-Yang Li, Yi-Yao Jiang… in Signal Transduction and Targeted Therapy (2020)

Article

Clinical characteristics and predictive value of lower CD4⁺T cell level in patients with moderate and severe COVID-19: a multicenter retrospective study

In December 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, Hubei, China. Moreover, it has become a global pandemic. This is o...

Xue-song Wen, Dan Jiang, Lei Gao, Jian-zhong Zhou, Jun **ao… in BMC Infectious Diseases (2021)

Article

Bispecific antibody simultaneously targeting PD1 and HER2 inhibits tumor growth via direct tumor cell killing in combination with PD1/PDL1 blockade and HER2 inhibition

Immune checkpoint blockade has shown significant clinical benefit in multiple cancer indications, but many patients are either refractory or become resistant to the treatment over time. HER2/neu oncogene overe...

Chang-ling Gu, Hai-xia Zhu, Lan Deng, **ao-qing Meng, Kai Li… in Acta Pharmacologica Sinica (2022)

Article

BOD1 regulates the cerebellar IV/V lobe-fastigial nucleus circuit associated with motor coordination

Cerebellar ataxias are characterized by a progressive decline in motor coordination, but the specific output circuits and underlying pathological mechanism remain poorly understood. Through cell-type-specific ...

**u-**u Liu, **ng-Hui Chen, Zhi-Wei Zheng… in Signal Transduction and Targeted Therapy (2022)

Article

Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces severe neural injuries, and is one of the leading causes of death and disability worldwide. Thus, it is of great nec...

Chuan Qin, Sheng Yang, Yun-Hui Chu, Hang Zhang… in Signal Transduction and Targeted Therapy (2022)

Article

Correction To: Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

Chuan Qin, Sheng Yang, Yun-Hui Chu, Hang Zhang… in Signal Transduction and Targeted Therapy (2022)

Article

A cross-sectional survey on the lung ultrasound training and practice of respiratory therapists in mainland China

This national study aimed to investigate the lung ultrasound (LUS) training and practice of respiratory therapists (RTs) in mainland China.

Kai Liu, Yu-long Yao, Yu-xian Wang, Bi-lin Wei, Liu-cun Li… in BMC Pulmonary Medicine (2022)

Article

Association between serum uric acid levels and bone mineral density in patients with osteoporosis: a cross-sectional study

The results of studies exploring the association between serum uric acid (SUA) and bone mineral density (BMD) have been controversial and inconsistent. We thus sought to explore whether SUA levels were indepen...

Min-zhe Xu, Ke Lu, Xu-feng Yang, Yao-wei Ye, Si-ming Xu… in BMC Musculoskeletal Disorders (2023)

Article

SIRT6 is an epigenetic repressor of thoracic aortic aneurysms via inhibiting inflammation and senescence

Thoracic aortic aneurysms (TAAs) develop asymptomatically and are characterized by dilatation of the aorta. This is considered a life-threating vascular disease due to the risk of aortic rupture and without ef...

Yang-Nan Ding, Ting-Ting Wang, Shuang-Jie Lv… in Signal Transduction and Targeted Therapy (2023)

Article

Association between perioperative blood transfusion and length of hospital stay in patients with osteoporotic fractures

Few studies have examined the relationship between perioperative blood transfusion (PBT) and length of hospital stay (LOS) in patients with osteoporotic fractures. This research aims to study the association b...

Si-ming Xu, Ke Lu, Xu-feng Yang, Yao-wei Ye, Min-zhe Xu… in BMC Musculoskeletal Disorders (2023)