7 Result(s)

Article

A comprehensive study of long-term skeletal changes after spinal cord injury in adult rats

Spinal cord injury (SCI)-induced bone loss represents the most severe osteoporosis with no effective treatment. Past animal studies have focused primarily on long bones at the acute stage using adolescent rode...

Tiao Lin, Wei Tong, Abhishek Chandra, Shao-Yun Hsu, Haoruo Jia, Ji Zhu… in Bone Research (2015)

Article

AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation

Patients with stage II or III colorectal cancer (CRC) exhibit various clinical outcomes after radical treatments. The 5-year survival rate was between 50 and 87%. However, the underlying mechanisms of the vari...

Ying-Nan Wang, Yun-**n Lu, Jie Liu, Ying **, Hui-Chang Bi, Qi Zhao… in Oncogene (2020)

Article

Role of the PPAR pathway in atrial fibrillation associated with heart valve disease: transcriptomics and proteomics in human atrial tissue

Huan-**n Chen, Ming-Yang Li, Yi-Yao Jiang… in Signal Transduction and Targeted Therapy (2020)

Article

BOD1 regulates the cerebellar IV/V lobe-fastigial nucleus circuit associated with motor coordination

Cerebellar ataxias are characterized by a progressive decline in motor coordination, but the specific output circuits and underlying pathological mechanism remain poorly understood. Through cell-type-specific ...

**u-**u Liu, **ng-Hui Chen, Zhi-Wei Zheng… in Signal Transduction and Targeted Therapy (2022)

Article

Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces severe neural injuries, and is one of the leading causes of death and disability worldwide. Thus, it is of great nec...

Chuan Qin, Sheng Yang, Yun-Hui Chu, Hang Zhang… in Signal Transduction and Targeted Therapy (2022)

Article

Correction To: Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

Chuan Qin, Sheng Yang, Yun-Hui Chu, Hang Zhang… in Signal Transduction and Targeted Therapy (2022)

Article

SIRT6 is an epigenetic repressor of thoracic aortic aneurysms via inhibiting inflammation and senescence

Thoracic aortic aneurysms (TAAs) develop asymptomatically and are characterized by dilatation of the aorta. This is considered a life-threating vascular disease due to the risk of aortic rupture and without ef...

Yang-Nan Ding, Ting-Ting Wang, Shuang-Jie Lv… in Signal Transduction and Targeted Therapy (2023)