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  1. Article

    Open Access

    The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer

    Colorectal cancer (CRC) patients with liver metastases usually obtain less benefit from immunotherapy, and the underlying mechanisms remain understudied. Here, we identify that fibrinogen-like protein 1 (FGL1)...

    Jia-Jun Li, **-Hong Wang, Tian Tian, Jia Liu, Yong-Qiang Zheng in Nature Communications (2023)

  2. Article

    Open Access

    A longitudinal resource for population neuroscience of school-age children and adolescents in China

    During the past decade, cognitive neuroscience has been calling for population diversity to address the challenge of validity and generalizability, ushering in a new era of population neuroscience. The develop...

    Xue-Ru Fan, Yin-Shan Wang, Da Chang, Ning Yang, Meng-Jie Rong, Zhe Zhang in Scientific Data (2023)

  3. Article

    Open Access

    Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis

    Recent interest in the control of bone metabolism has focused on a specialized subset of CD31hiendomucinhi vessels, which are reported to couple angiogenesis with osteogenesis. However, the underlying mechanisms ...

    Rong Fu, Wen-Cong Lv, Ying Xu, Mu-Yun Gong, **ao-Jie Chen in Nature Communications (2020)

  4. Article

    Open Access

    Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling

    Retinoid X receptor-alpha (RXRα) is a potent regulator of inflammatory responses; however, its therapeutic potential for inflammatory cancer remains to be explored. We previously discovered that RXRα is abnorm...

    **aohong Ye, Hua Wu, Luoyan Sheng, Yi-xin Liu, Fang Ye, Mo Wang in Nature Communications (2019)

  5. Article

    Open Access

    A rigid and healable polymer cross-linked by weak but abundant Zn(II)-carboxylate interactions

    Achieving a desirable combination of solid-like properties and fast self-healing is a great challenge due to slow diffusion dynamics. In this work, we describe a design concept that utilizes weak but abundant ...

    Jian-Cheng Lai, Lan Li, Da-Peng Wang, Min-Hao Zhang, Sheng-Ran Mo in Nature Communications (2018)

  6. Article

    Open Access

    MicroRNA-122 as a predictor of HBsAg seroclearance in hepatitis B and C dual infected patients treated with interferon and ribavirin

    It has been demonstrated that microRNA-122 (miR-122) plays key roles in the modulation of hepatitis B virus (HBV) replication. This study examined the role of miR-122 in patients with hepatitis C virus (HCV)-H...

    Yi-Hao Yen, Chao-Min Huang, Kuo-Liang Wei, **g-Houng Wang in Scientific Reports (2016)