19 Result(s)

Article

S1PR1 regulates ovarian cancer cell senescence through the PDK1-LATS1/2-YAP pathway

Cell senescence deters the activation of various oncogenes. Induction of senescence is, therefore, a potentially effective strategy to interfere with vital processes in tumor cells. Sphingosine-1-phosphate rec...

Yi-** Tao, Heng-Yan Zhu, Qian-Yuan Shi, Cai-**a Wang, Yu-**n Hua, Han-Yin Hu… in Oncogene (2023)

Article

Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson’s disease

Inflammation is one of the pathogenic processes in Parkinson’s disease (PD). Dopamine receptor agonist pramipexole (PPX) is extensively used for PD treatment in clinics. A number of studies show that PPX exert...

An-qi Dong, Ya-** Yang, Shu-min Jiang, **ao-yu Yao, Di Qi… in Acta Pharmacologica Sinica (2023)

Article

Elevated N-terminal pro C-type natriuretic peptide is associated with mortality in patients undergoing transcatheter aortic valve replacement

Unlike N-terminal pro-B-type natriuretic peptide (NT-proBNP), which have been extensively studied, little is known about the role of N-terminal pro-C-type natriuretic peptide (NT-proCNP) for predicting surviva...

Po Hu, Han Chen, Li-Han Wang, Ju-Bo Jiang, Jia-Min Li… in BMC Cardiovascular Disorders (2022)

Article

Tendon‐to‐bone healing after repairing full‐thickness rotator cuff tear with a triple‐loaded single‐row method in young patients

Arthroscopic repair is recommended for young patients with full-thickness rotator cuff tears (RCTs), but the healing rates have raised concerns. The Southern California Orthopedic Institute (SCOI) row method h...

He-Bei He, Tao Wang, Min-Cong Wang, Hui-Feng Zhu, Yue Meng… in BMC Musculoskeletal Disorders (2021)

Article

Thamnolia vermicularis extract improves learning ability in APP/PS1 transgenic mice by ameliorating both Aβ and Tau pathologies

Considering the complicated pathogenesis of Alzheimer's disease (AD), multi-targets have become a focus in the discovery of drugs for treatment of this disease. In the current work, we established a multi-targ...

Cong Li, **ao-dan Guo, Min Lei, Jia-yi Wu, Jia-zhen **… in Acta Pharmacologica Sinica (2017)

Article

Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system

Pulmonary arterial hypertension (PAH) is commonly accompanied with the activation of the renin-angiotensin-aldosterone system (RAAS). Renal sympathetic denervation (RSD) reduces PAH partly through the inhibiti...

Chen Liu, **ao-Min Jiang, Juan Zhang, Bing Li, **g Li… in BMC Cardiovascular Disorders (2016)

Article

Bufalin derivative BF211 inhibits proteasome activity in human lung cancer cells in vitro by inhibiting β1 subunit expression and disrupting proteasome assembly

Bufalin is one of the active components in the traditional Chinese medicine ChanSu that is used to treat arrhythmia, inflammation and cancer. BF211 is a bufalin derivative with stronger cytotoxic activity in c...

Peng Sun, Li-xing Feng, Dong-mei Zhang, Miao Liu, Wang Liu… in Acta Pharmacologica Sinica (2016)

Article

Blocking TLR2 activity diminishes and stabilizes advanced atherosclerotic lesions in apolipoprotein E-deficient mice

Toll-like receptor 2 (TLR2) signaling plays a critical role in the initiation of atherosclerosis. The aim of this study was to investigate whether blocking TLR2 activity could produce therapeutic effects on ad...

**ao-xing Wang, **ao-xi Lv, Jia-** Wang, Hui-min Yan… in Acta Pharmacologica Sinica (2013)

Article

Drug packaging and delivery using perfluorocarbon nanoparticles for targeted inhibition of vascular smooth muscle cells

To investigate the in vitro release profile of drugs encapsulated within perfluorocarbon (PFC) nanoparticles (NPs) and their ability to inhibit the activity of vascular smooth muscle cells (SMCs).

Zhao-xiong Zhou, Bai-gen Zhang, Hao Zhang, **ao-zhong Huang… in Acta Pharmacologica Sinica (2009)

Article

Evaluation of CYP3A activity in humans using three different parameters based on endogenous cortisol metabolism

Currently, there is considerable debate as to which method is more accurate for measuring the activity of CYP3A in vivo: cortisol 6β-hydroxylation clearance (Cl_m(6β)) or the urinary ratio of 6β-OHF to F (6β-OHF/F...

** Luo, **ao-min Li, Zhe-yi Hu, Ze-neng Cheng in Acta Pharmacologica Sinica (2009)

Article

Oridonin induces apoptosis via PI3K/Akt pathway in cervical carcinoma HeLa cell line

To investigate the apoptosis-inducing effect of oridonin, a diterpenoid isolated from Rabdosia rubescens, in the human cervical carcinoma HeLa cell line.

Hong-zhen Hu, Yue-bo Yang, **ang-dong Xu, Hong-wei Shen… in Acta Pharmacologica Sinica (2007)

Article

Granulocyte-macrophage colony-stimulating factor DNA prime-protein boost strategy to enhance efficacy of a recombinant pertussis DNA vaccine

To investigate a new strategy to enhance the efficacy of a recombinant pertussis DNA vaccine. The strategy is co-injection with cytokine plasmids as prime, and boosted with purified homologous proteins.

Qing-tian Li, Yong-zhang Zhu, Jia-you Chu, Ke Dong, ** He… in Acta Pharmacologica Sinica (2006)

Article

35th Annual Meeting of the European Association for the Study of Diabetes

A. Melander, J. Olsson, G. Lindberg, A. Salzman, T. Howard, P. Stang… in Diabetologia (1999)