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Article
ErbB4 deficiency exacerbates olfactory dysfunction in an early-stage Alzheimer’s disease mouse model
Olfactory dysfunction is increasingly recognized as an early indicator of Alzheimer’s disease (AD). Aberrations in GABAergic function and the excitatory/inhibitory (E/I) balance within the olfactory bulb (OB) ...
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Article
Structural engineering of Sb-based electrode materials to enhance advanced sodium-ion batteries
Antimony (Sb) is recognized as a potential electrode material for sodium-ion batteries (SIBs) due to its huge reserves, affordability, and high theoretical capacity (660 mAh·g−1). However, Sb-based materials expe...
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Article
VEGF-induced Nrdp1 deficiency in vascular endothelial cells promotes cancer metastasis by degrading vascular basement membrane
Vascular endothelial cells (VECs) are key players in the formation of neovessels and tumor metastasis, the ultimate cause of the majority of cancer-related human death. However, the crosstalk between VECs and ...
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Article
Open AccessCLK2 mediates IκBα-independent early termination of NF-κB activation by inducing cytoplasmic redistribution and degradation
Activation of the NF-κB pathway is strictly regulated to prevent excessive inflammatory and immune responses. In a well-known negative feedback model, IκBα-dependent NF-κB termination is a delayed response pat...
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Article
Cpd-A1 alleviates acute kidney injury by inhibiting ferroptosis
Acute kidney injury (AKI) is defined as sudden loss of renal function characterized by increased serum creatinine levels and reduced urinary output with a duration of 7 days. Ferroptosis, an iron-dependent reg...
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Article
Open AccessMonitoring trends in the absolute lymphocyte count and the neutrophil-to-lymphocyte ratio in patients with breast cancer receiving eribulin
Studies have shown that the absolute lymphocyte count (ALC) and the neutrophil-to-lymphocyte ratio (NLR) are related to the outcomes in patients with breast cancer receiving specific chemotherapies. However, t...
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Article
Robust Optimization Dispatch Method for Distribution Network Considering Four-Quadrant Power Output of Energy Storage Devices
This paper describes a technique for improving distribution network dispatch by using the four-quadrant power output of distributed energy storage systems to address voltage deviation and grid loss problems re...
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Article
Observation of plaid-like spin splitting in a noncoplanar antiferromagnet
Spatial, momentum and energy separation of electronic spins in condensed-matter systems guides the development of new devices in which spin-polarized current is generated and manipulated1–3. Recent attention on a...
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Article
Open AccessEBV DNA methylation profiles and its application in distinguishing nasopharyngeal carcinoma and nasal NK/T-cell lymphoma
As an oncovirus, EBV is associated with multiple cancers, including solid tumors and hematological malignancies. EBV methylation plays an important role in regulating tumor occurrence. However, the EBV methyla...
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Article
Open AccessAdvances in nuclear detection and readout techniques
“A Craftsman Must Sharpen His Tools to Do His Job,” said Confucius. Nuclear detection and readout techniques are the foundation of particle physics, nuclear physics, and particle astrophysics to reveal the nat...
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Article
Open AccessInsights into the missing apiosylation step in flavonoid apiosides biosynthesis of Leguminosae plants
Apiose is a natural pentose containing an unusual branched-chain structure. Apiosides are bioactive natural products widely present in the plant kingdom. However, little is known on the key apiosylation reacti...
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Article
Open AccessLoss-of-function variants in human C12orf40 cause male infertility by blocking meiotic progression
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Article
Open AccessA longitudinal resource for population neuroscience of school-age children and adolescents in China
During the past decade, cognitive neuroscience has been calling for population diversity to address the challenge of validity and generalizability, ushering in a new era of population neuroscience. The develop...
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Article
AIWW: a new nutrition-screening tool for the oncologic population
Malnutrition is a common comorbidity among patients with cancer. However, no nutrition-screening tool has been recognized in this population. A quick and easy screening tool for nutrition with high sensitivity...
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Article
New Interpretation of Neonatal Outcomes by Phenotypically Classified Preterm Syndrome: A Retrospective Cohort Study
The global aim to lower preterm birth rates has been hampered by the insufficient and incomplete understanding of its etiology, classification, and diagnosis. This study was designed to evaluate the associatio...
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Article
Analgesic Effect of Perineural Injection of BoNT/A on Neuropathic Pain Induced by Chronic Constriction Injury of Sciatic Nerve in Rats
This study was designed to investigate the analgesic effect of perineural injection of BoNT/A on neuropathic pain induced by sciatic nerve chronic constriction injury (CCI) and possible mechanisms. SD rats wer...
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Article
Actively switchable polarization converter for reflection and transmission in the same terahertz frequencies
A metamaterial-based dual-function switchable polarization conversion device working in terahertz frequency regime is proposed and verified by both numerical methods of finite element method and finite differe...
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Article
Open AccessIsolation and characterization of three pairs of verrucosidin epimers from the marine sediment-derived fungus Penicillium cyclopium and configuration revision of penicyrone A and related analogues
Verrucosidins, a methylated α-pyrone class of polyketides rarely reported upon, have been implicated in one or more neurological diseases. Despite the significance of verrucosidins as neurotoxins, the absolute...
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Article
Open AccessGenome-wide placental DNA methylations in fetal overgrowth and associations with leptin, adiponectin and fetal growth factors
Fetal overgrowth “programs” an elevated risk of type 2 diabetes in adulthood. Epigenetic alterations may be a mechanism in programming the vulnerability. We sought to characterize genome-wide alterations in pl...
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Article
Psychological Resilience Mediates the Association Between Childhood Maltreatment and Self-Harm Phenotype in Chinese Early Adolescents
Self-harm (SH) increases significantly in early adolescence with great variability, and childhood maltreatment (CM) contributes to this increase. Understanding the developmental pathway from CM to SH could pro...
