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  1. No Access

    Article

    MRI-detected tumor deposits in cT3 and cT4 rectal cancer following neoadjuvant chemoradiotherapy

    To evaluate the identification of tumor deposits (TDs) and the prognostic significance of an MRI tumor regression grade for TDs in patients with rectal cancer treated with neoadjuvant chemoradiotherapy (nCRT).

    Yu-Tao Que, Yan Chen, **n-Yue Yang, Yu-Ru Ma, Yi-Yan Liu in European Radiology (2024)

  2. Article

    Open Access

    Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1

    Develo** a mucosal vaccine against SARS-CoV-2 is critical for combatting the epidemic. Here, we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a t...

    **an Li, Mengxin Xu, **gyi Yang, Li Zhou in Signal Transduction and Targeted Therapy (2024)

  3. No Access

    Article

    Role of dynamic contrast-enhanced MRI in predicting severe acute radiation-induced rectal injury in patients with rectal cancer

    To explore the potential of dynamic contrast-enhanced MRI (DCE-MRI) quantitative parameters in predicting severe acute radiation-induced rectal injury (RRI) in rectal cancer.

    Yan Chen, Li Ding, Zhi-wen Zhang, Xue-han Wu, Yu-tao Que, Yu-ru Ma in European Radiology (2024)

  4. No Access

    Article

    Neuronal intranuclear inclusion disease with cortical involvement in left hemisphere: a case report

    Neuronal intranuclear inclusion disease (NIID) is a rare highly heterogeneous disease. In this paper, we present a case of NIID featured in cortical involvement in left hemisphere of brain and the imaging chan...

    **ao-ju Wu, Yi-ying Jiang, Li-jie Chen, Guo-qiu Zhou in Wiener klinische Wochenschrift (2024)

  5. Article

    Open Access

    Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

    There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC...

    Hai-Dong Zhu, Hai-Liang Li, Ming-Sheng Huang in Signal Transduction and Targeted Therapy (2023)

  6. No Access

    Article

    EPSTI1 promotes monocyte adhesion to endothelial cells in vitro via upregulating VCAM-1 and ICAM-1 expression

    Atherosclerosis is a chronic inflammatory disease of arterial wall, and circulating monocyte adhesion to endothelial cells is a crucial step in the pathogenesis of atherosclerosis. Epithelial-stromal interacti...

    Yan-rou Bei, Shun-chi Zhang, Yu Song, Mao-lin Tang in Acta Pharmacologica Sinica (2023)

  7. Article

    Open Access

    Quantitative assessment of the microstructure of the mesorectum with different prognostic statuses by intravoxel incoherent motion diffusion-weighed magnetic resonance imaging

    The mesorectum surrounding the rectum provides an ideal substrate for tumour spread. However, preoperative risk assessment is still an issue. This study aimed to investigate the microstructural features of mes...

    Bao-Lan Lu, Yan Chen, Zi-Qiang Wen, Yi-Yan Liu, Yu-Ru Ma in BMC Gastroenterology (2022)

  8. Article

    Open Access

    Risk Factors for Generalization in Patients with Ocular Myasthenia Gravis: A Multicenter Retrospective Cohort Study

    Many patients with ocular myasthenia gravis (OMG) progress to generalized disease within the first 2 years of the onset of ocular symptoms. Several retrospective studies have identified risk factors associated...

    Rong-**g Guo, Ting Gao, Zhe Ruan, Hong-Yu Zhou, Feng Gao, Quan Xu in Neurology and Therapy (2022)

  9. Article

    Open Access

    Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats

    Acute myocardial injury (AMI), which is induced by renal ischemia-reperfusion (IR), is a significant cause of acute kidney injury (AKI)-related associated death. Obesity increases the severity and frequency of...

    He Tai, **ao-lin Jiang, Zhi-ming Lan, Yue Li in BMC Complementary Medicine and Therapies (2021)

  10. No Access

    Article

    Prognostic and predictive value of a microRNA signature in adults with T-cell lymphoblastic lymphoma

    New prognostic factors are needed to establish indications for haematopoietic stem cell transplantation (HSCT) in first complete remission (CR1) for T-cell lymphoblastic lymphoma (T-LBL) patients. We used micr...

    **ao-Peng Tian, Wei-Juan Huang, Hui-Qiang Huang, Yan-Hui Liu, Liang Wang in Leukemia (2019)

  11. Article

    Open Access

    Radiological and clinical outcomes of cervical disc arthroplasty for the elderly: a comparison with young patients

    This study aimed to investigate whether cervical disc arthroplasty (CDA) would be equally effective in elderly patients as in the young. The inclusion criteria of published clinical trials for CDA-enrolled pat...

    Jau-Ching Wu, Hsuan-Kan Chang, Wen-Cheng Huang in BMC Musculoskeletal Disorders (2019)

  12. Article

    Open Access

    World Congress Integrative Medicine & Health 2017: Part one

    Benno Brinkhaus, Torkel Falkenberg in BMC Complementary and Alternative Medicine (2017)

  13. No Access

    Article

    IGF-I stimulates ERβ and aromatase expression via IGF1R/PI3K/AKT-mediated transcriptional activation in endometriosis

    Estrogen receptor beta (ERβ, encoded by ESR2 gene) and cytochrome P450 aromatase (encoded by CYP19A1 gene) play critical roles in endometriosis, and the levels of insulin-like growth factor-I (IGF-I) in the perit...

    Yan Zhou, Cheng Zeng, **n Li, Pei-Li Wu, Ling Yin in Journal of Molecular Medicine (2016)

  14. Article

    Pharmacokinetics and pharmacodynamics of SCT800, a new recombinant FVIII, in hemophilia A mice

    SCT800 is a new third-generation recombinant FVIII agent that is undergoing promising preclinical study. This study aimed to investigate the pharmacokinetic and pharmacodynamic profiles of SCT800 in hemophilia...

    Ruo-lan Gu, Liang Liu, Liang-zhi **e, Wen-lin Gai in Acta Pharmacologica Sinica (2016)

  15. Article

    Open Access

    A cross-sectional study of the clinical characteristics of hospitalized children with community-acquired pneumonia in eight eastern cities in China

    Community-acquired pneumonia in children is common in China. To understand current clinical characteristics and practice, we conducted a cross-sectional study to analyze quality of care on childhood pneumonia ...

    Xue-Feng Wang, Jian-** Liu, Kun-Ling Shen in BMC Complementary and Alternative Medicine (2013)

  16. Article

    Open Access

    Updated molecular epidemiology of carbapenem-non-susceptible Escherichia coli in Taiwan: first identification of KPC-2 or NDM-1-producing E. coliin Taiwan

    The global spread and increasing incidence of carbapenem-resistant Enterobacteriaceae have resulted in treatment and public health concerns. Here, we present an investigation of the molecular mechanisms and cl...

    Ling Ma, L Kristopher Siu, Jung-Chung Lin, Tsu-Lan Wu in BMC Infectious Diseases (2013)

  17. Article

    Pharmacokinetic interactions between 20(S)-ginsenoside Rh2 and the HIV protease inhibitor ritonavir in vitro and in vivo

    20(S)-Ginsenoside Rh2 (Rh2) has shown potent inhibition on P-glycoprotein (P-gp), while most HIV protease inhibitors are both substrates and inhibitors of P-gp and CYP3A4. The aim of this study was to investigate...

    Jian Shi, Bei Cao, Wei-bin Zha, **ao-lan Wu, Lin-sheng Liu in Acta Pharmacologica Sinica (2013)

  18. Article

    Open Access

    The effect of Chinese **zhida recipe on the hippocampus in a rat model of diabetes-associated cognitive decline

    To investigate the effects of treatment with Multi component Chinese Medicine **zhida (JZD) on behavioral deficits in diabetes-associated cognitive decline (DACD) rats and verify our hypothesis that JZD treat...

    **ao-Hui Chang, Li-Na Liang, Li-Bin Zhan in BMC Complementary and Alternative Medicine (2013)

  19. Article

    The antiproliferative effects of somatostatin receptor subtype 2 in breast cancer cells

    Somatostatin receptor subtype 2 (SSTR2) is the principal mediator of somatostatin's (SST) antiproliferative effects on normal and cancer cells. Therefore, we investigated whether the enhanced expression of SST...

    Yong He, **ao-mei Yuan, ** Lei, Sha Wu, Wei **ng in Acta Pharmacologica Sinica (2009)

  20. Article

    35th Annual Meeting of the European Association for the Study of Diabetes

    A. Melander, J. Olsson, G. Lindberg, A. Salzman, T. Howard, P. Stang in Diabetologia (1999)