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Open AccessOrexin signaling modulates synchronized excitation in the sublaterodorsal tegmental nucleus to stabilize REM sleep
The relationship between orexin/hypocretin and rapid eye movement (REM) sleep remains elusive. Here, we find that a proportion of orexin neurons project to the sublaterodorsal tegmental nucleus (SLD) and exhib...
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Article
Open AccessAntioxidative capacity is highly associated with the storage property of tuberous roots in different sweetpotato cultivars
The activities and gene expression of antioxidative enzymes and the ROS content were analyzed in two typical storage-tolerant cultivars (Xushu 32 and Shangshu 19) and another two storage-sensitive cultivars (Y...
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Article
Open AccessBeam Steering Using Momentum-Reconfigurable Goubau Meta-Line Radiators
Spoof/designer surface plasmon polaritons (SPP) and Goubau line belong to the same category of single-conductor surface waveguide. They feature easy integration and high field confinement capability, and hence...
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Article
Open AccessExposure to podophyllotoxin inhibits oocyte meiosis by disturbing meiotic spindle formation
Podophyllotoxin is used as medical cream which is widely applied to genital warts and molluscum contagiosum. Although previous study showed that podophyllotoxin had minimal toxicity, it was forbidden to use du...
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Article
Open AccessBidirectional modulation between infiltrating CD3+ T-lymphocytes and astrocytes in the spinal cord drives the development of allodynia in monoarthritic rats
Increasing evidence suggests that T cells and glia participate in the process of neuropathic pain. However, little is known about the involvement of T cells or the interaction between glia and T cells at the m...
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Article
Open AccessContinuous Beam Steering Through Broadside Using Asymmetrically Modulated Goubau Line Leaky-Wave Antennas
Goubau line is a single-conductor transmission line, featuring easy integration and low-loss transmission properties. Here, we propose a periodic leaky-wave antenna (LWA) based on planar Goubau transmission li...
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Article
Open AccessDifferent Effects of sgRNA Length on CRISPR-mediated Gene Knockout Efficiency
CRISPR-Cas9 is a powerful genome editing technology, yet with off-target effects. Truncated sgRNAs (17nt) have been found to decrease off-target cleavage without affecting on-target disruption in 293T cells. H...
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Open AccessAncient Chinese Formula Qiong-Yu-Gao Protects Against Cisplatin-Induced Nephrotoxicity Without Reducing Anti-tumor Activity
Cisplatin is a highly effective anti-cancer chemotherapeutic agent; however, its clinical use is severely limited by serious side effects, of which nephrotoxicity is the most important. In this study, we inves...