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  1. No Access

    Article

    Inhibition of PPP1R15A alleviates osteoporosis via suppressing RANKL-induced osteoclastogenesis

    Osteoporosis results from overactivation of osteoclasts. There are currently few drug options for treatment of this disease. Since the successful development of allosteric inhibitors, phosphatases have become ...

    Zong-bao Ding, Yan Chen, Yu-rong Zheng, Yi-yuan Wang… in Acta Pharmacologica Sinica (2024)

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    Article

    Bispecific antibody targeting both B7-H3 and PD-L1 exhibits superior antitumor activities

    Clinical application of PD-1 and PD-L1 monoclonal antibodies (mAbs) is hindered by their relatively low response rates and the occurrence of drug resistance. Co-expression of B7-H3 with PD-L1 has been found in...

    Hua-ying Li, Yi-li Chen, **ang-nan Deng, Huan-huan Li… in Acta Pharmacologica Sinica (2023)

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    Article

    Oridonin ameliorates inflammation-induced bone loss in mice via suppressing DC-STAMP expression

    Currently, dendritic cell-specific transmembrane protein (DC-STAMP), a multipass transmembrane protein, is considered as the master regulator of cell–cell fusion, which underlies the formation of functional mu...

    Bin-hua Zou, Yan-hui Tan, Wen-de Deng, Jie-huang Zheng… in Acta Pharmacologica Sinica (2021)

  4. No Access

    Article

    Oridonin Attenuates TNBS-induced Post-inflammatory Irritable Bowel Syndrome via PXR/NF-κB Signaling

    To investigate the beneficial effects of oridonin, a diterpenoid compound isolated from Rabdosia rubescens, on the inflammatory response in TNBS-induced post-inflammatory irritable bowel syndrome (PI-IBS) mode...

    Yun-yun Shao, Yao Guo, **ao-juan Feng, Jun-** Liu, Zhuang-peng Chang… in Inflammation (2021)