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Article
Effect of Mn addition on microstructure and mechanical properties of GX40CrNiSi25-12 austenitic heat resistant steel
Three types of steels were designed on the basis of GX40CrNiSi25-12 austenitic heat resistant steel by adding different Mn contents (2wt.%, 6wt.%, and 12wt.%). Thermodynamic calculation, microstructure charact...
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Article
Structure of GPR101–Gs enables identification of ligands with rejuvenating potential
GPR101 is an orphan G protein-coupled receptor actively participating in energy homeostasis. Here we report the cryo-electron microscopy structure of GPR101 constitutively coupled to Gs heterotrimer, which rev...
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Article
Metal(Loid)s in Aquatic Products and Their Potential Health Risk
Aquatic products decrease environmental burdens and improve human health by supplying various essential nutrients, while their contamination with metal(loid)s could pose health risks to humans through food cha...
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Article
Open AccessPhagotrophic protists preserve antibiotic-resistant opportunistic human pathogens in the vegetable phyllosphere
Food safety of leafy greens is an emerging public health issue as they can harbor opportunistic human pathogens (OHPs) and expose OHPs to consumers. Protists are an integral part of phyllosphere microbial ecos...
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Article
A large area 3He tube array detector with vacuum operation capacity for the SANS instrument at the CSNS
The small-angle neutron scattering (SANS) instrument, one of the first three instruments of the China Spallation Neutron Source (CSNS), is designed to probe the microscopic and mesoscopic structures of materia...
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Article
Open AccessReduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder
The nucleus accumbens (NAc) is considered a hub of reward processing and a growing body of evidence has suggested its crucial role in the pathophysiology of major depressive disorder (MDD). However, inconsiste...
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Article
Open AccessGrowth differentiation factor 1-induced tumour plasticity provides a therapeutic window for immunotherapy in hepatocellular carcinoma
Tumour lineage plasticity is an emerging hallmark of aggressive tumours. Tumour cells usually hijack developmental signalling pathways to gain cellular plasticity and evade therapeutic targeting. In the presen...
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Article
Open AccessDisrupted intrinsic functional brain topology in patients with major depressive disorder
Aberrant topological organization of whole-brain networks has been inconsistently reported in studies of patients with major depressive disorder (MDD), reflecting limited sample sizes. To address this issue, w...
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Article
Open AccessThe design and sensitivity of JUNO’s scintillator radiopurity pre-detector OSIRIS
The OSIRIS detector is a subsystem of the liquid scintillator filling chain of the JUNO reactor neutrino experiment. Its purpose is to validate the radiopurity of the scintillator to assure that all components...
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Article
Test of a \(^{3}\) He neutron detector readout electronics prototype for CSNS multipurpose physics neutron diffractometer
Large areas of \(^{3}\) 3 ...
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Article
Open AccessCharacterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing
The remarkable advances in next-generation sequencing technology have enabled the wide usage of sequencing as a clinical tool. To promote the advance of precision oncology for breast cancer in China, here we r...
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Article
Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins
The ongoing outbreak of viral pneumonia in China and across the world is associated with a new coronavirus, SARS-CoV-21. This outbreak has been tentatively associated with a seafood market in Wuhan, China, where ...
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Article
Open AccessCorrection to: Promoter hypomethylation mediated upregulation of MicroRNA-10b-3p targets FOXO3 to promote the progression of esophageal squamous cell carcinoma (ESCC)
In the original publication of this manuscript [1], Fig. 6 contains a repeated image in error (the left image of ‘Migration’ and the left image of ‘Invasion’).
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Article
Promotion of conversion activity of flue gas desulfurization gypsum into α-hemihydrate gypsum by calcination-hydration treatment
The massive accumulation of flue gas desulfurization (FGD) gypsum produced in the wet limestone-gypsum flue gas desulfurization process not only encroaches on lands but also causes serious environmental pollut...
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Article
Open AccessPromoter hypomethylation mediated upregulation of MicroRNA-10b-3p targets FOXO3 to promote the progression of esophageal squamous cell carcinoma (ESCC)
Esophageal cancer is a high incident cancer worldwide with poor survival and limited therapeutic options. Alterations of microRNAs are common in cancers, and many of these micro RNAs are potential therapeutic ...
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Article
Antioxidant activities of four superoxide dismutases in Metarhizium robertsii and their contributions to pest control potential
The superoxide dismutase (SOD) family of Metarhizium robertsii, a fungal insect pathogen, comprises six members functionally unknown yet, including Cu/ZnSODs (Sod1/5/6), MnSODs (Sod2/3), and FeSOD (Sod4). Here, w...
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Article
A development of lifetime measurement based on the differential decay curve method
A new development of indirect gating case in the differential decay curve method used for lifetime measurement has been introduced. The gate region was extended from partial shifted peak to both shifted and un...
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Article
Bioactivity, toxicity and detoxification assessment of Dioscorea bulbifera L.: a comprehensive review
Dioscorea bulbifera L. (Chinese: Huangdu, common name: air potato) is a traditional herbal medicine in China, and it is also one of the most widely consumed yam species, especially in Wes...
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Article
Open AccessDifferential Roles for Six P-Type Calcium ATPases in Sustaining Intracellular Ca2+ Homeostasis, Asexual Cycle and Environmental Fitness of Beauveria bassiana
A global insight into the roles of multiple P-type calcium ATPase (CA) pumps in sustaining the life of a filamentous fungal pathogen is lacking. Here we elucidated the functions of five CA pumps (Eca1, Spf1 an...
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Article
Open Access31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one
