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Article
Open AccessCD11b maintains West Nile virus replication through modulation of immune response in human neuroblastoma cells
West Nile virus (WNV) is a rapidly spreading mosquito-borne virus accounted for neuroinvasive diseases. An insight into WNV-host factors interaction is necessary for development of therapeutic approaches again...
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Article
Programming an efficient technique for designing smart C-doped MIC with dual self-protection for information and high-energy
Constructing self-protected metastable intermolecular composites (MICs) enables the regulation of microstructures towards boosting controllable detonation performance, and also prevents information leakage, wh...
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Article
Risk Factors and Predictive Nomogram for Survival in Elderly Patients with Brain Glioma
To determine the factors that contribute to the survival of elderly individuals diagnosed with brain glioma and develop a prognostic nomogram.
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Article
Efficient elimination of trace iodide ions from medical wastewater by Cu/Cu2O@AC composites
Cu/Cu2O-modified activated carbon composites (Cu/Cu2O@AC) were synthesized via an one-step solvothermal method. The characterization results indicated that copper was uniformly dispersed on the surface of AC as n...
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Article
Publisher Correction: E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1
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Article
Reference Intervals of Serum Iodine Concentration in Chinese Pregnant Women
The study aims to establish trimester-specific reference ranges for serum iodine (SI) in Chinese pregnant women and explore its associations with maternal and infantile thyroid function. Apparently healthy pre...
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Article
Fermentation of Rice Straw and Its Hydrolysate with Sludge for Ethanol Production
Rice straw hydrolysate produced in rice straw pretreatment, comprising a lot of fermentable sugars, is generally released into the environment. This not only causes environment pollution but also wastes fermen...
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Article
E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1
The circadian clock is the inner rhythm of life activities and is controlled by a self-sustained and endogenous molecular clock, which maintains a ~ 24 h internal oscillation. As the core element of the circad...
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Article
Open AccessTargeted inhibition of the HNF1A/SHH axis by triptolide overcomes paclitaxel resistance in non-small cell lung cancer
Paclitaxel resistance is associated with a poor prognosis in non-small cell lung cancer (NSCLC) patients, and currently, there is no promising drug for paclitaxel resistance. In this study, we investigated the...
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Article
Open AccessEnhanced cellular therapy: revolutionizing adoptive cellular therapy
Enhanced cellular therapy has emerged as a novel concept following the basis of cellular therapy. This treatment modality applied drugs or biotechnology to directly enhance or genetically modify cells to enhan...
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Article
Open AccessThrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson’s disease
The neurotoxic α-synuclein (α-syn) oligomers play an important role in the occurrence and development of Parkinson’s disease (PD), but the factors affecting α-syn generation and neurotoxicity remain unclear. W...
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Article
Open AccessMulti-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression
Clear cell renal cell carcinoma (ccRCC) is a complex disease with remarkable immune and metabolic heterogeneity. Here we perform genomic, transcriptomic, proteomic, metabolomic and spatial transcriptomic and m...
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Article
Solibacillus ferritrahens sp. nov., a novel siderophore-producing bacterium isolated from Wumeng Mountain National Nature Reserve in Yunnan Province
A gram-stain-positive, aerobic, rod-shaped bacterial strain capable of producing siderophores, named YIM B08730T, was isolated from a soil sample collected from Wumeng Mountain National Nature Reserve, Zhaotong C...
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Article
Effect of Al Content on Microstructure and Mechanical Properties of the fcc and bcc Phases of AlxCoCrFeNi High Entropy Alloys
In the AlxCoCrFeNi high entropy alloys (HEAs), adding Al promotes a microstructure shift from fcc to bcc or their mixtures, which increases the overall strength of the alloys. To understand the strengthening mech...
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Article
Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain
Chronic pain often develops severe mood changes such as depression. However, how chronic pain leads to depression remains elusive and the mechanisms determining individuals’ responses to depression are largely...
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Chapter and Conference Paper
The Successful Application of Expansion Tube Technology in the Bongor Basin of Chad
The Bongor is the main basin for increasing storage and production in the CNPC Chad. With the continuous deepening of development, underground safety operations face the following problems: the inability to ef...
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Chapter and Conference Paper
Influencing Factors and Countermeasures of Cementing Quality in Tangdong Area of Dagang Oilfield
Tangdong region of Dagang oilfield as a key block for high-efficiency storage enhancement, oil and gas are abnormally active, medium pressure stability during the cementation process is paradoxically outstandi...
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Chapter and Conference Paper
Sensitivity Quantification Study on the Main Influencing Factors of Water-Flooding Development in Medium Permeability Reservoir
There are many factors that affect the development effect In the development process of medium porosity and permeability reservoirs. Clarifying the degree of influence of different influencing factors is condu...
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Chapter and Conference Paper
Pilot Study on Enhanced Oil Recovery by Gravity Assisted Deoxygenated Air Flooding in N Fault Block
In order to solve the problem of poor water flooding development effect of extra-low permeability reservoir in Dagang Oilfield, N fault block is selected to carry out continuous gas injection and intermittent ...
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Article
Open AccessAdvances in nuclear detection and readout techniques
“A Craftsman Must Sharpen His Tools to Do His Job,” said Confucius. Nuclear detection and readout techniques are the foundation of particle physics, nuclear physics, and particle astrophysics to reveal the nat...
