15 Result(s)

Article

Co-administration of paroxetine and pravastatin causes deregulation of glucose homeostasis in diabetic rats via enhanced paroxetine exposure

Clinical evidence shows that co-administration of pravastatin and paroxetine deregulates glucose homeostasis in diabetic patients. The aim of this study was to verify this phenomenon in diabetic rats and to el...

Feng Li, Mian Zhang, Dan Xu, Can Liu, Ze-yu Zhong… in Acta Pharmacologica Sinica (2014)

Article

Decreased exposure of simvastatin and simvastatin acid in a rat model of type 2 diabetes

Simvastatin is frequently administered to diabetic patients with hypercholesterolemia. The aim of the study was to investigate the pharmacokinetics of simvastatin and its hydrolysate simvastatin acid in a rat ...

Dan Xu, Feng Li, Mian Zhang, Ji Zhang, Can Liu, Meng-yue Hu… in Acta Pharmacologica Sinica (2014)

Article

Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance

Streptozotocin (STZ) is widely used to induce oxidative damage and to impair glucose metabolism, apoptosis, and tau/Aβ pathology, eventually leading to cognitive deficits in both in vitro and in vivo models of Al...

**ao-dan Guo, Guang-long Sun, Ting-ting Zhou, **n Xu… in Acta Pharmacologica Sinica (2016)

Article

Thamnolia vermicularis extract improves learning ability in APP/PS1 transgenic mice by ameliorating both Aβ and Tau pathologies

Considering the complicated pathogenesis of Alzheimer's disease (AD), multi-targets have become a focus in the discovery of drugs for treatment of this disease. In the current work, we established a multi-targ...

Cong Li, **ao-dan Guo, Min Lei, Jia-yi Wu, Jia-zhen **… in Acta Pharmacologica Sinica (2017)

Article

LX2343 alleviates cognitive impairments in AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy

Alzheimer's disease (AD) is a progressive neurodegenerative disease leading to the irreversible loss of brain neurons and cognitive abilities, and the vicious interplay between oxidative stress (OS) and tauopa...

**ao-dan Guo, Guang-long Sun, Ting-ting Zhou, Yi-yang Wang… in Acta Pharmacologica Sinica (2017)

Article

Clinical implications of pathological features of primary membranous nephropathy

The clinical outcome varies considerably in primary membranous nephropathy (pMN). Risk factors for kidney prognosis include ageing, male gender, persistent heavy proteinuria, decreased eGFR at presentation, pe...

**ao-dan Zhang, Zhao Cui, Mu-fan Zhang, Jia Wang, Yi-miao Zhang, Zhen Qu… in BMC Nephrology (2018)

Article

BRD4 and PIN1 gene polymorphisms are associated with high pulse pressure risk in a southeastern Chinese population

BRD4 and PIN1 have been described to be involved in inflammation and vascular endothelial cell dysfunction, which in turn may increase pulse pressure.

**-jia Qiu, Rui-zhi Yang, Yi-jie Tang, Ying-yi Lin… in BMC Cardiovascular Disorders (2020)

Article

AI detection of mild COVID-19 pneumonia from chest CT scans

An artificial intelligence model was adopted to identify mild COVID-19 pneumonia from computed tomography (CT) volumes, and its diagnostic performance was then evaluated.

**-Cao Yao, Tao Wang, Guang-Hua Hou, Di Ou, Wei Li, Qiao-Dan Zhu… in European Radiology (2021)

Article

Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis

Met tyrosine kinase, a receptor for a hepatocyte growth factor (HGF), plays a critical role in tumor growth, metastasis, and drug resistance. Mitochondria are highly dynamic and undergo fission and fusion to m...

Yan Yu, **ao-Dan Peng, **ao-Jun Qian… in Signal Transduction and Targeted Therapy (2021)

Article

Risk Factors for Generalization in Patients with Ocular Myasthenia Gravis: A Multicenter Retrospective Cohort Study

Many patients with ocular myasthenia gravis (OMG) progress to generalized disease within the first 2 years of the onset of ocular symptoms. Several retrospective studies have identified risk factors associated...

Rong-**g Guo, Ting Gao, Zhe Ruan, Hong-Yu Zhou, Feng Gao, Quan Xu… in Neurology and Therapy (2022)

Article

c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses

B cells secreting IL-10 functionally are recognized as functional regulatory B (B_reg) cells; however, direct evidence concerning the phenotype, regulation, and functional and clinical relevance of IL-10-secreting...

Xu-Yan Wang, Yuan Wei, Bo Hu, Yuan Liao… in Signal Transduction and Targeted Therapy (2022)

Article

FGF10 mitigates doxorubicin-induced myocardial toxicity in mice via activation of FGFR2b/PHLDA1/AKT axis

Doxorubicin is a common chemotherapeutic agent in clinic, but myocardial toxicity limits its use. Fibroblast growth factor (FGF) 10, a multifunctional paracrine growth factor, plays diverse roles in embryonic ...

De-pu Zhou, Lian-cheng Deng, **ao Feng, Hui-**g Xu, Ye Tian… in Acta Pharmacologica Sinica (2023)

Article

Correction: c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses

Xu-Yan Wang, Yuan Wei, Bo Hu, Yuan Liao… in Signal Transduction and Targeted Therapy (2024)

Article

Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy

RNA-binding proteins (RBPs)-RNA networks have contributed to cancer development. Circular RNAs (circRNAs) are considered as protein recruiters; nevertheless, the patterns of circRNA-protein interactions in col...

Ri-**n Chen, Shui-Dan Xu, Min-Hua Deng… in Signal Transduction and Targeted Therapy (2024)

Article

Author Correction: Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance

**ao-dan Guo, Guang-long Sun, Ting-ting Zhou, **n Xu… in Acta Pharmacologica Sinica (2024)