8 Result(s)

Article

Co-administration of paroxetine and pravastatin causes deregulation of glucose homeostasis in diabetic rats via enhanced paroxetine exposure

Clinical evidence shows that co-administration of pravastatin and paroxetine deregulates glucose homeostasis in diabetic patients. The aim of this study was to verify this phenomenon in diabetic rats and to el...

Feng Li, Mian Zhang, Dan Xu, Can Liu, Ze-yu Zhong… in Acta Pharmacologica Sinica (2014)

Article

Decreased exposure of simvastatin and simvastatin acid in a rat model of type 2 diabetes

Simvastatin is frequently administered to diabetic patients with hypercholesterolemia. The aim of the study was to investigate the pharmacokinetics of simvastatin and its hydrolysate simvastatin acid in a rat ...

Dan Xu, Feng Li, Mian Zhang, Ji Zhang, Can Liu, Meng-yue Hu… in Acta Pharmacologica Sinica (2014)

Article

Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance

Streptozotocin (STZ) is widely used to induce oxidative damage and to impair glucose metabolism, apoptosis, and tau/Aβ pathology, eventually leading to cognitive deficits in both in vitro and in vivo models of Al...

**ao-dan Guo, Guang-long Sun, Ting-ting Zhou, **n Xu… in Acta Pharmacologica Sinica (2016)

Article

Thamnolia vermicularis extract improves learning ability in APP/PS1 transgenic mice by ameliorating both Aβ and Tau pathologies

Considering the complicated pathogenesis of Alzheimer's disease (AD), multi-targets have become a focus in the discovery of drugs for treatment of this disease. In the current work, we established a multi-targ...

Cong Li, **ao-dan Guo, Min Lei, Jia-yi Wu, Jia-zhen **… in Acta Pharmacologica Sinica (2017)

Article

LX2343 alleviates cognitive impairments in AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy

Alzheimer's disease (AD) is a progressive neurodegenerative disease leading to the irreversible loss of brain neurons and cognitive abilities, and the vicious interplay between oxidative stress (OS) and tauopa...

**ao-dan Guo, Guang-long Sun, Ting-ting Zhou, Yi-yang Wang… in Acta Pharmacologica Sinica (2017)

Article

FGF10 mitigates doxorubicin-induced myocardial toxicity in mice via activation of FGFR2b/PHLDA1/AKT axis

Doxorubicin is a common chemotherapeutic agent in clinic, but myocardial toxicity limits its use. Fibroblast growth factor (FGF) 10, a multifunctional paracrine growth factor, plays diverse roles in embryonic ...

De-pu Zhou, Lian-cheng Deng, **ao Feng, Hui-**g Xu, Ye Tian… in Acta Pharmacologica Sinica (2023)

Article

Author Correction: Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance

**ao-dan Guo, Guang-long Sun, Ting-ting Zhou, **n Xu… in Acta Pharmacologica Sinica (2024)