50 Result(s)

Article

A novel surgical scheme for hepatectomy in hepatocellular carcinoma patients with clinically significant portal hypertension

Clinically significant portal hypertension (CSPH) seriously affects the feasibility and safety of surgical treatment for hepatocellular carcinoma (HCC) patients. The aim of this study was to establish a new su...

Jia-zhou Ye, Hua-ze Lu, Can Zeng, Guo Lei, **ao-bo Wang, Jie Chen, Tao Bai… in BMC Cancer (2024)

Article

Dynamic genomic changes in methotrexate-resistant human cancer cell lines beyond DHFR amplification suggest potential new targets for preventing drug resistance

Although DHFR gene amplification has long been known as a major mechanism for methotrexate (MTX) resistance in cancer, the early changes and detailed development of the resistance are not yet fully understood.

**ang-Ning Meng, **-Fa Ma, Yang-He Liu, Si-Qing Li, Xu Wang… in British Journal of Cancer (2024)

Article

TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro

There is a lack of effective therapeutic strategies for amyotrophic lateral sclerosis (ALS); therefore, drug repurposing might provide a rapid approach to meet the urgent need for treatment.

Qing-Qing Duan, Han Wang, Wei-Ming Su, **ao-**g Gu, **ao-Fei Shen… in BMC Medicine (2024)

Article

Expanding causal genes for Parkinson’s disease via multi-omics analysis

Genome‑wide association studies (GWASs) have revealed numerous loci associated with Parkinson’s disease (PD). However, some potential causal/risk genes were still not revealed and no etiological therapies are ...

**ao-**g Gu, Wei-Ming Su, Meng Dou, Zheng Jiang, Qing-Qing Duan… in npj Parkinson's Disease (2023)

Article

Personalized radiomics signature to screen for KIT-11 mutation genotypes among patients with gastrointestinal stromal tumors: a retrospective multicenter study

Gastrointestinal stromal tumors (GISTs) carrying different KIT exon 11 (KIT-11) mutations exhibit varying prognoses and responses to Imatinib. Herein, we aimed to determine whether computed tomography (CT) rad...

Qing-Wei Zhang, Ran-Ying Zhang, Zhi-Bo Yan… in Journal of Translational Medicine (2023)

Article

Neuroprotective effect and possible mechanism of edaravone in rat models of spinal cord injury: a protocol for a systematic review and meta-analysis

Spinal cord injury (SCI) is one of the most disabling neurological conditions, afflicting thousands of human beings. Edaravone, a well-known reactive oxygen species scavenger, is expanding its new scope in fie...

**ao-bo Wang, Long-yun Zhou, Xu-qing Chen, Ran Li, Bin-bin Yu… in Systematic Reviews (2023)

Article

Author Correction: Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors

Guo-zhen Cao, Li-ying Ma, Zong-hui Zhang, **ao-lin Wang… in Acta Pharmacologica Sinica (2023)

Article

CpG-binding protein CFP1 promotes ovarian cancer cell proliferation by regulating BST2 transcription

Epigenetic alterations have been functionally linked to ovarian cancer development and occurrence. The CXXC zinc finger protein 1 (CFP1) is an epigenetic regulator involved in DNA methylation and histone modif...

Liu-Qing Yang, Han-Yin Hu, Yao Han, Ze-Yi Tang, Jie Gao, Qi-Yin Zhou… in Cancer Gene Therapy (2022)

Article

Both indirect maternal and direct fetal genetic effects reflect the observational relationship between higher birth weight and lower adult bone mass

Birth weight is considered not only to undermine future growth, but also to induce lifelong diseases; the aim of this study is to explore the relationship between birth weight and adult bone mass.

Jiang-Wei **a, Lin Zhang, ** Li, Cheng-Da Yuan, **ao-Wei Zhu, Yu Qian… in BMC Medicine (2022)

Article

LncRNA TMPO-AS1 promotes esophageal squamous cell carcinoma progression by forming biomolecular condensates with FUS and p300 to regulate TMPO transcription

Esophageal squamous cell carcinoma (ESCC) is one of the most life- and health-threatening malignant diseases worldwide, especially in China. Long noncoding RNAs (lncRNAs) have emerged as important regulators o...

**ao-**g Luo, Ming-Ming He, Jia Liu, Jia-Bo Zheng… in Experimental & Molecular Medicine (2022)

Article

Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma

HDAC inhibitors (HDACis) have been intensively studied for their roles and potential as drug targets in T-cell lymphomas and other hematologic malignancies. Bisthianostat is a novel bisthiazole-based pan-HDACi...

Yu-bo Zhou, Yang-ming Zhang, Hong-hui Huang, Li-**g Shen… in Acta Pharmacologica Sinica (2022)

Article

Step-by-step and orderly lowering of the height of inferior vena cava tumor thrombus is the key to robot-assisted thrombectomy for Mayo III/IV tumor thrombus

The surgical management of Mayo III/IV tumor thrombi is difficult and risky, and robotic surgery is even more difficult. The purpose of this study was to introduce the step-by-step and orderly lowering of the ...

Guo-Dong Zhao, **u-** Zhang, Ming-Gen Hu, Qing-Bao Huang, Shuai Xu… in BMC Cancer (2022)

Article

Influence of early colorectal cancer component on the positive margins after endoscopic resection: a retrospective study

Endoscopic treatment methods for early colorectal cancer (ECRC) mainly depend on the size and morphology. It is unclear whether different endoscopic resection methods could achieve curative resection for ECRC ...

Qing-Wei Zhang, Zi-Hao Dai, **ao-Yi Wang, Yun-Jie Gao, Zhi-Zheng Ge… in BMC Cancer (2022)

Article

Comparison of submucosal and subserosal approaches toward optimized indocyanine green tracer-guided laparoscopic lymphadenectomy for patients with gastric cancer (FUGES-019): a randomized controlled trial

Application of indocyanine green (ICG) fluorescence imaging is effective in guiding laparoscopic radical lymphadenectomy for gastric cancer. However, the optimal approach for indocyanine green injection is con...

Qi-Yue Chen, Qing Zhong, ** Li, Jian-Wei **e, Zhi-Yu Liu, **ao-Bo Huang… in BMC Medicine (2021)

Article

Neo-adjuvant radiation therapy provides a survival advantage in T3-T4 nodal positive gastric and gastroesophageal junction adenocarcinoma: a SEER database analysis

Due to negative results in clinical trials of postoperative chemoradiation for gastric cancer, at present, there is a tendency to move chemoradiation therapy forward in gastric and gastroesophageal junction (G...

Yu-Jie Zhou, **ao-Fan Lu, Jia-Lin Meng, **n-Yuan Wang, Qing-Wei Zhang… in BMC Cancer (2021)

Article

A nomogram based on combining systemic and hepatic inflammation markers for predicting microscopic bile duct tumour thrombus in hepatocellular carcinoma

Bile duct invasion is a relatively rare event and is not well characterised in hepatocellular carcinoma (HCC). It remains very difficult to diagnose HCC with bile duct tumour thrombus (BDTT) before surgery. In...

Jun-Yi Wu, Ju-**an Sun, Jia-Yi Wu, **ao-**ao Huang, Yan-Nan Bai, Yong-Yi Zeng… in BMC Cancer (2021)

Article

Antibody responses to SARS-CoV-2 in patients with COVID-19

We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG...

Quan-**n Long, Bai-Zhong Liu, Hai-Jun Deng, Gui-Cheng Wu, Kun Deng… in Nature Medicine (2020)

Article

Disease-free survival as a surrogate endpoint for overall survival in adjuvant trials of pancreatic cancer: a meta-analysis of 20 randomized controlled trials

We aimed to assess whether disease-free survival (DFS) could serve as a reliable surrogate endpoint for overall survival (OS) in adjuvant trials of pancreatic cancer.

Run-Cong Nie, Xue-Bin Zou, Shu-Qiang Yuan, Ying-Bo Chen, Shi Chen… in BMC Cancer (2020)

Article

Diverse roles of macrophage polarization in aortic aneurysm: destruction and repair

Aortic aneurysm (AA) is defined as an enlargement of the aorta greater than 1.5 times its normal size. Early diagnosis of AA is challenging and mortality of AA is high. Curative pharmacological treatments for ...

Zhao Cheng, Yang-zhao Zhou, Yin Wu, Qi-ying Wu… in Journal of Translational Medicine (2018)

Article

Efficacy and indication optimization of Chinese medicine (Tiao-Chang Ke-Min granules) for diarrhea-predominant irritable bowel syndrome: study protocol for a randomized controlled trial

Irritable bowel syndrome (IBS) is a chronic, recurring condition, prevalent in the general population. Current medication treatments usually leave patients undertreated. Nowadays, Chinese medicine (CM) is bein...

Qian Li, Bei-** Zhang, Shao-gang Huang, Wen-wei Ouyang, Jian-hui **e… in Trials (2018)