76 Result(s)

Article

A novel surgical scheme for hepatectomy in hepatocellular carcinoma patients with clinically significant portal hypertension

Clinically significant portal hypertension (CSPH) seriously affects the feasibility and safety of surgical treatment for hepatocellular carcinoma (HCC) patients. The aim of this study was to establish a new su...

Jia-zhou Ye, Hua-ze Lu, Can Zeng, Guo Lei, **ao-bo Wang, Jie Chen, Tao Bai… in BMC Cancer (2024)

Article

Dynamic genomic changes in methotrexate-resistant human cancer cell lines beyond DHFR amplification suggest potential new targets for preventing drug resistance

Although DHFR gene amplification has long been known as a major mechanism for methotrexate (MTX) resistance in cancer, the early changes and detailed development of the resistance are not yet fully understood.

**ang-Ning Meng, **-Fa Ma, Yang-He Liu, Si-Qing Li, Xu Wang… in British Journal of Cancer (2024)

Article

Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer’s disease

Adult neurogenesis occurs in the subventricular zone (SVZ) and the subgranular zone of the dentate gyrus in the hippocampus. The neuronal stem cells in these two neurogenic niches respond differently to variou...

Dongfang Jiang, Hongmei Liu, Tingting Li, Song Zhao… in Translational Neurodegeneration (2024)

Article

Development and evaluation of serological screening based on one dried plasma spot for HIV, syphilis, and HCV

In the effort to prevent and control HIV/AIDS, China has established a national sentinel surveillance system. However, some sentinel sites face limitations in environmental resources and accessibility, prompti...

Jie-qiong Ma, Ya-nan Ren, Shi-yuan Wen, Ao-bo Dong, Wen-ge **ng… in Virology Journal (2023)

Article

Expanding causal genes for Parkinson’s disease via multi-omics analysis

Genome‑wide association studies (GWASs) have revealed numerous loci associated with Parkinson’s disease (PD). However, some potential causal/risk genes were still not revealed and no etiological therapies are ...

**ao-**g Gu, Wei-Ming Su, Meng Dou, Zheng Jiang, Qing-Qing Duan… in npj Parkinson's Disease (2023)

Article

Personalized radiomics signature to screen for KIT-11 mutation genotypes among patients with gastrointestinal stromal tumors: a retrospective multicenter study

Gastrointestinal stromal tumors (GISTs) carrying different KIT exon 11 (KIT-11) mutations exhibit varying prognoses and responses to Imatinib. Herein, we aimed to determine whether computed tomography (CT) rad...

Qing-Wei Zhang, Ran-Ying Zhang, Zhi-Bo Yan… in Journal of Translational Medicine (2023)

Article

Author Correction: Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors

Guo-zhen Cao, Li-ying Ma, Zong-hui Zhang, **ao-lin Wang… in Acta Pharmacologica Sinica (2023)

Article

New insights into the impact of microbiome on horizontal and vertical transmission of a tick-borne pathogen

The impact of host skin microbiome on horizontal transmission of tick-borne pathogens , and of pathogen associated transstadial and transovarial changes in tick microbiome are largely unknown, but are importan...

Li-Feng Du, Ming-Zhu Zhang, Ting-Ting Yuan, Xue-Bing Ni, Wei Wei… in Microbiome (2023)

Article

CpG-binding protein CFP1 promotes ovarian cancer cell proliferation by regulating BST2 transcription

Epigenetic alterations have been functionally linked to ovarian cancer development and occurrence. The CXXC zinc finger protein 1 (CFP1) is an epigenetic regulator involved in DNA methylation and histone modif...

Liu-Qing Yang, Han-Yin Hu, Yao Han, Ze-Yi Tang, Jie Gao, Qi-Yin Zhou… in Cancer Gene Therapy (2022)

Article

LncRNA TMPO-AS1 promotes esophageal squamous cell carcinoma progression by forming biomolecular condensates with FUS and p300 to regulate TMPO transcription

Esophageal squamous cell carcinoma (ESCC) is one of the most life- and health-threatening malignant diseases worldwide, especially in China. Long noncoding RNAs (lncRNAs) have emerged as important regulators o...

**ao-**g Luo, Ming-Ming He, Jia Liu, Jia-Bo Zheng… in Experimental & Molecular Medicine (2022)

Article

Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma

HDAC inhibitors (HDACis) have been intensively studied for their roles and potential as drug targets in T-cell lymphomas and other hematologic malignancies. Bisthianostat is a novel bisthiazole-based pan-HDACi...

Yu-bo Zhou, Yang-ming Zhang, Hong-hui Huang, Li-**g Shen… in Acta Pharmacologica Sinica (2022)

Article

Step-by-step and orderly lowering of the height of inferior vena cava tumor thrombus is the key to robot-assisted thrombectomy for Mayo III/IV tumor thrombus

The surgical management of Mayo III/IV tumor thrombi is difficult and risky, and robotic surgery is even more difficult. The purpose of this study was to introduce the step-by-step and orderly lowering of the ...

Guo-Dong Zhao, **u-** Zhang, Ming-Gen Hu, Qing-Bao Huang, Shuai Xu… in BMC Cancer (2022)

Article

Influence of early colorectal cancer component on the positive margins after endoscopic resection: a retrospective study

Endoscopic treatment methods for early colorectal cancer (ECRC) mainly depend on the size and morphology. It is unclear whether different endoscopic resection methods could achieve curative resection for ECRC ...

Qing-Wei Zhang, Zi-Hao Dai, **ao-Yi Wang, Yun-Jie Gao, Zhi-Zheng Ge… in BMC Cancer (2022)

Article

The role of carbonic anhydrase III and autophagy in type 2 diabetes with cardio-cerebrovascular disease

Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases among the elderly people. The T2DM increases the risk of cardio-cerebrovascular disease (CCD), and the main pathological change of the...

**ao-Ming Zhang, Ying-Hong Tao, **u-Ling Zhou, **-Liang Shang… in Metabolic Brain Disease (2021)

Article

Anti-osteosarcoma effect of antiserum against cross antigen TPD52 between osteosarcoma and Trichinella spiralis

Trichinella spiralis (T. spiralis) is a parasite occurring worldwide that has been proven to have antitumour ability. However, studies on the antitumour effects of cross antigens between the tumour and T. spirali...

Tao-Tao Yue, Nan Zhang, Jian-Hua Li, **ang-Yun Lu, **ao-Cen Wang… in Parasites & Vectors (2021)

Article

Neo-adjuvant radiation therapy provides a survival advantage in T3-T4 nodal positive gastric and gastroesophageal junction adenocarcinoma: a SEER database analysis

Due to negative results in clinical trials of postoperative chemoradiation for gastric cancer, at present, there is a tendency to move chemoradiation therapy forward in gastric and gastroesophageal junction (G...

Yu-Jie Zhou, **ao-Fan Lu, Jia-Lin Meng, **n-Yuan Wang, Qing-Wei Zhang… in BMC Cancer (2021)

Article

NLRP3 ablation enhances tolerance in heat stroke pathology by inhibiting IL-1β-mediated neuroinflammation

Patients with prior illness are more vulnerable to heat stroke-induced injury, but the underlying mechanism is unknown. Recent studies suggested that NLRP3 inflammasome played an important role in the pathophy...

Zi-Teng Zhang, **ao-Lei Gu, **n Zhao, **an He, Hao-Wei Shi… in Journal of Neuroinflammation (2021)

Article

TLR8 in the Trigeminal Ganglion Contributes to the Maintenance of Trigeminal Neuropathic Pain in Mice

Trigeminal neuropathic pain (TNP) is a significant health problem but the involved mechanism has not been completely elucidated. Toll-like receptors (TLRs) have recently been demonstrated to be expressed in th...

Lin-**a Zhao, Ming Jiang, Xue-Qiang Bai, De-Li Cao, **ao-Bo Wu… in Neuroscience Bulletin (2021)

Article

A nomogram based on combining systemic and hepatic inflammation markers for predicting microscopic bile duct tumour thrombus in hepatocellular carcinoma

Bile duct invasion is a relatively rare event and is not well characterised in hepatocellular carcinoma (HCC). It remains very difficult to diagnose HCC with bile duct tumour thrombus (BDTT) before surgery. In...

Jun-Yi Wu, Ju-**an Sun, Jia-Yi Wu, **ao-**ao Huang, Yan-Nan Bai, Yong-Yi Zeng… in BMC Cancer (2021)

Article

m⁶A modification-mediated BATF2 acts as a tumor suppressor in gastric cancer through inhibition of ERK signaling

BATF2, also known as SARI, has been implicated in tumor progression. However, its role, underlying mechanisms, and prognostic significance in human gastric cancer (GC) are elusive.

Jian-Wei **e, **ao-Bo Huang, Qi-Yue Chen, Yu-Bin Ma, Ya-Jun Zhao… in Molecular Cancer (2020)