180 Result(s)

Article

Serum Lactate Is an Indicator for Short-Term and Long-Term Mortality in Patients with Acute Pancreatitis

Serum lactate, as a single and an easily available biomarker, has been applied in various diseases.

Zhao Zeng, Rong Huang, Hang Lin, Hongchun Peng, Ju Luo… in Digestive Diseases and Sciences (2024)

Article

Endoscopic Longitudinal Incision and Recanalization in the Treatment of Acquired Esophageal Atresia (with Video)

Meng-Nan Xu, Hong-Yu Chen, Bai-Rong Li, Teng Li… in Digestive Diseases and Sciences (2024)

Article

Metabolic Heterogeneity and Potential Immunotherapeutic Responses Revealed by Single-Cell Transcriptomics of Breast Cancer

Breast cancer (BC) exhibits remarkable heterogeneity. However, the transcriptomic heterogeneity of BC at the single-cell level has not been fully elucidated.

Shicong Tang, Qing Wang, Ke Sun, Ying Song, Rui Liu, **n Tan, Huimeng Li… in Apoptosis (2024)

Article

Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce ATF3 transcription: a novel mechanism underlying the restrained malignant properties of ccRCC cells

Dysregulation of deubiquitination contributes to various diseases, including cancer, and aberrant expression of deubiquitinating enzymes is involved in carcinoma progression. As a member of the ovarian tumor (...

Ziyao Li, Ye Tian, Huafeng Zong, Xuelei Wang, Dongyang Li, Adili Keranmu… in Apoptosis (2024)

Article

Ferroptosis: underlying mechanisms and involvement in neurodegenerative diseases

Ferroptosis, a mode of cell death that was recently identified in 2012, is driven by iron-dependent lipid peroxidation and distinct from other mechanisms of cell death such as autophagy and apoptosis. Ferropto...

Yi Wang, Hong**g Li, Qian**ong He, Rong Zou, **Rui Cai, Lin Zhang in Apoptosis (2024)

Article

Comparison of Fluid Resuscitation with Lactate Ringer's Versus Normal Saline in Acute Pancreatitis: An Updated Meta-Analysis

Fluid resuscitation is one of the main therapies for acute pancreatitis (AP). There is still no consensus on the type of fluid resuscitation. This study investigated the differences between lactate Ringer’s (L...

Jiaze Hong, Qingyuan Li, Yiran Wang, Lizhi **ang… in Digestive Diseases and Sciences (2024)

Article

Triptolide induces PANoptosis in macrophages and causes organ injury in mice

Macrophages represent the first lines of innate defense against pathogenic infections and are poised to undergo multiple forms of regulated cell death (RCD) upon infections or toxic stimuli, leading to multipl...

Hong-Rui Zhang, Ya-** Li, Zi-Jian Shi, Qi-Qi Liang, Si-Yuan Chen… in Apoptosis (2023)

Article

BMI Modifies the Association Between Depression Symptoms and Serum Copper Levels

Depression is one of the most common mental disorders which dramatically threatens public health and wellness. Copper has been known to be involved in many biological processes that could help explaining the o...

Wu Hongrong, Li Qingqi, Gao Rong, Tang Shuangyang… in Biological Trace Element Research (2023)

Article

Sodium butyrate induces ferroptosis in endometrial cancer cells via the RBM3/SLC7A11 axis

Ferroptosis is a form of programmed cell death with important biological functions in the progression of various diseases, and targeting ferroptosis is a new tumor treatment strategy. Studies have shown that s...

Ziwei Wang, Wan Shu, Rong Zhao, Yan Liu, Hongbo Wang in Apoptosis (2023)

Article

Tcf21 Alleviates Pancreatic Fibrosis by Regulating the Epithelial-Mesenchymal Transformation of Pancreatic Stellate Cells

The activation of pancreatic stellate cells (PSCs) plays a key role in the occurrence and development of chronic pancreatitis (CP) and pancreatic fibrosis, which is related to the process of epithelial-mesench...

Yan-Hong Ni, Rong Wang, Wen Wang, Da-Zhou Li, Gang Liu… in Digestive Diseases and Sciences (2023)

Article

Essential Trace Element Status in Systemic Lupus Erythematosus: a Meta-analysis Based on Case-Control Studies

The homeostasis of trace elements is essential to regulate different aspects of the immune system and might play important roles in systemic lupus erythematosus (SLE). However, epidemiological evidences that c...

Hua Wang, **an-Bao Li, Rong-Gui Huang, Nv-Wei Cao… in Biological Trace Element Research (2023)

Article

NEDD8-Activating Enzyme Inhibitor MLN4924 Inhibits Both the Tumor Stroma and Angiogenesis in Pancreatic Cancer via Gli1 and REDD1

Pancreatic cancer is characterized by a dense desmoplasia stroma, which hinders efficient drug delivery and plays a critical role in tumor progression and metastasis. MLN4924 is a first-in-class NEDD8-activati...

Weilin Mao, Lei Zhang, Yefei Rong, Tiantao Kuang… in Digestive Diseases and Sciences (2023)

Article

Influence of Garlic (Allium sativum) Clove-Based Selenium Nanoparticles on Status of Nutritional, Biochemical, Enzymological, and Gene Expressions in the Freshwater Prawn Macrobrachium rosenbergii (De Man, 1879)

Selenium (Se) is one of the essential micronutrients for performing vital body functions. This study aims at examining the influence of dietary supplementation of garlic clove-based green-synthesized selenium ...

Thangavelu Satgurunathan, Periyakali Saravana Bhavan… in Biological Trace Element Research (2023)

Article

Exploring the potential anti-Alzheimer disease mechanisms of Alpiniae Oxyphyliae Fructus by network pharmacology study and molecular docking

Alpiniae Oxyphyliae Fructus (AOF) (yizhi) is a frequently medicated Chinese herb for Alzheimer disease (AD) treatment. The present study investigated the components and potential mechanisms of AOF through network...

Rong-Rong Zhen, Yan-Jie Qu, Li-Min Zhang, Chao Gu, Min-Rui Ding… in Metabolic Brain Disease (2023)

Article

Tetramethylpyrazine protects neural stem cells against sevoflurane-induced toxicity through Akt/GSK-3β pathway

Sevoflurane, a commonly used anesthetic, has been found to cause neural stem cell (NSC) injury, thereby contributing to neurocognitive impairment following general anesthesia. Tetramethylpyrazine (TMP), one of...

Yan Feng, Kui Wang, Ning Wang, Pengyu Jia, Lei Zhang… in Metabolic Brain Disease (2022)

Article

Auricular Vagus Nerve Stimulation Ameliorates Functional Dyspepsia with Depressive-Like Behavior and Inhibits the Hypothalamus–Pituitary–Adrenal Axis in a Rat Model

The hypothalamus–pituitary–adrenal axis is the most important endocrine system to control irritability response. Functional dyspepsia (FD) is closely related to irritability. This study aimed to preliminarily ...

Li-wei Hou, Ji-liang Fang, **-ling Zhang, Lei Wang… in Digestive Diseases and Sciences (2022)

Article

Protective Effect of Selenium on the Oxidative Damage of Kidney Cells Induced by Sodium Nitrite in Grass Carp (Ctenopharyngodon idellus)

The present study was conducted to investigate the protective effects of selenium on the oxidative damage of kidney cells (CIK) caused by nitrite exposure in grass carp (Ctenopharyngodon idella). Cells were pre-i...

Tingting Zhang, Chaorui Yao, Zhenyi Hu, Dapeng Li… in Biological Trace Element Research (2022)

Article

NGF/TrkA promotes the vitality, migration and adhesion of bone marrow stromal cells in hypoxia by regulating the Nrf2 pathway

Bone marrow stromal cells (BMSCs) transplantation is a treatment strategy for ischemic stroke (IS) with great potential. However, the vitality, migration and adhesion of BMSCs are greatly impaired due to the h...

Cui-Ni Fang, Hai-Qun Tan, Ao-Bo Song, Ni Jiang, Qian-Rong Liu… in Metabolic Brain Disease (2022)