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    An optically active isochroman-2H-chromene conjugate potently suppresses neuronal oxidative injuries associated with the PI3K/Akt and MAPK signaling pathways

    Increasing evidence suggests that the use of potent neuroprotective agents featured with novel pharmacological mechanism would offer a promising strategy to delay or prevent the progression of neurodegeneratio...

    Ling-xue Tao, Sha-sha Ji, Dóra Szalóki, Tibor Kovács in Acta Pharmacologica Sinica (2021)

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    Acetylcholinesterase-independent protective effects of huperzine A against iron overload-induced oxidative damage and aberrant iron metabolism signaling in rat cortical neurons

    Iron dyshomeostasis is one of the primary causes of neuronal death in Alzheimer's disease (AD). Huperzine A (HupA), a natural inhibitor of acetylcholinesterase (AChE), is a licensed anti-AD drug in China and a...

    Ling-xue Tao, **ao-tian Huang, Yu-ting Chen, **-can Tang in Acta Pharmacologica Sinica (2016)