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An optically active isochroman-2H-chromene conjugate potently suppresses neuronal oxidative injuries associated with the PI3K/Akt and MAPK signaling pathways

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  1. Article

    Open Access

    Pulmonary effects of exposure to indium and its compounds: cross-sectional survey of exposed workers and experimental findings in rodents

    Many studies have shown that occupational exposure to indium and its compounds could induce lung disease. Although animal toxicological studies and human epidemiological studies suggest indium exposure may cau...

    Nan Liu, Yi Guan, Yan Yu, Gai Li, Ling Xue, Weikang Li… in Particle and Fibre Toxicology (2022)

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  2. Article

    Open Access

    Immunization with a fusion protein vaccine candidate generated from truncated peptides of human enterovirus 71 protects mice from lethal enterovirus 71 infections

    Prophylactic vaccines are critical in preventing hand, foot, and mouth disease (HFMD) primarily caused by human enterovirus 71 (EV71) infection. Children aged less than 5 years are especially susceptible to EV...

    Jiangning Liu, Binbin Zhao, Ling Xue, **g Wu, Yanfeng Xu, Yongdong Liu… in Virology Journal (2020)

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  3. Article

    Chimeric Newcastle disease virus-vectored vaccine protects chickens against H9N2 avian influenza virus in the presence of pre-existing NDV immunity

    A chimeric Newcastle disease virus (NDV) vector (NDV/AI4-TFHN) was constructed with the replacement of the ectodomains of the fusion and hemagglutinin-neuraminidase proteins by those from avian paramyxovirus t...

    **g**g Liu, Ling Xue, Shunlin Hu, Hao Cheng, Yonghuan Deng… in Archives of Virology (2018)

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  4. Article

    Open Access

    Testes-specific protease 50 (TSP50) promotes invasion and metastasis by inducing EMT in gastric cancer

    TSP50 (testes-specific protease 50) has been reported to be a candidate oncogene and is overexpressed in various cancers. Our previous study demonstrated that TSP50 protein is elevated in gastric cancer, and i...

    Qing-Hua Cao, Fang Liu, Chang-Zhao Li, Ni Liu, Man Shu, Yuan Lin, Li Ding… in BMC Cancer (2018)

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  5. Article

    Acetylcholinesterase-independent protective effects of huperzine A against iron overload-induced oxidative damage and aberrant iron metabolism signaling in rat cortical neurons

    Iron dyshomeostasis is one of the primary causes of neuronal death in Alzheimer's disease (AD). Huperzine A (HupA), a natural inhibitor of acetylcholinesterase (AChE), is a licensed anti-AD drug in China and a...

    Ling-xue Tao, **ao-tian Huang, Yu-ting Chen, **-can Tang… in Acta Pharmacologica Sinica (2016)

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  6. Article

    Open Access

    Overexpression of GOLPH3 is associated with poor prognosis and clinical progression in pancreatic ductal adenocarcinoma

    Golgi phosphoprotein 3 (GOLPH3) has been identified as an oncoprotein in various human cancers; however, its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. We examined GOLPH3 expression levels and...

    Luan-**g Zhang, Ke-Bing Wang, Long-shan Liu, Lian-zhou Chen, Bao-Gang Peng… in BMC Cancer (2014)

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