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Article
Open AccessAnalysis of differences in the rumen microbiome and metabolic function in prepartum dairy cows with different body condition scores
The rumen is a crucial digestive organ for dairy cows. The rumen microbiota assists in the digestion of plant feed through microbe-mediated fermentation, during which the plant feed is transformed into nutrien...
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Article
Open AccessMedullary sponge kidney with IgA nephropathy: a case report and literature review
Medullary sponge kidney (MSK)is rare in association with glomerulonephritis. We report a patient with medullary sponge kidney, and the kidney biopsy revealed a diagnosis of IgA nephropathy.
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Article
Scientific Advances and Weather Services of the China Meteorological Administration’s National Forecasting Systems during the Bei**g 2022 Winter Olympics
Since the Bei**g 2022 Winter Olympics was the first Winter Olympics in history held in continental winter monsoon climate conditions across complex terrain areas, there is a deficiency of relevant research, o...
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Article
Open AccessDeep-learning-based upscaling method for geologic models via theory-guided convolutional neural network
Large-scale or high-resolution geologic models usually comprise a huge number of grid blocks, which can be computationally demanding and time-consuming to solve with numerical simulators. Therefore, it is adva...
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Article
Open AccessNifuroxazide boosts the anticancer efficacy of palbociclib-induced senescence by dual inhibition of STAT3 and CDK2 in triple-negative breast cancer
Though palbociclib, a cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor has been approved for treating breast cancer, two major clinical challenges remain: (i) Triple-negative breast cancer (TNBC) appears to...
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Article
Open AccessSDMA attenuates renal tubulointerstitial fibrosis through inhibition of STAT4
Renal tubulointerstitial fibrosis is the hallmark of various chronic kidney diseases. Symmetric dimethylarginine (SDMA) is an independent cardiovascular risk factor in patients with chronic kidney diseases, wh...
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Article
Open AccessOxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus
Although extracellular DNA is known to form immune complexes (ICs) with autoantibodies in systemic lupus erythematosus (SLE), the mechanisms leading to the release of DNA from cells remain poorly characterized...
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Article
Open AccessTranscriptome analysis provides insights into light condition effect on paclitaxel biosynthesis in yew saplings
Taxus is a rare gymnosperm plant that is the sole producer of the anticancer drug paclitaxel. The growth and development of Taxus is affected by environmental factors such as light. However, little is known about...
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Article
Open AccessA Lagrangian dual-based theory-guided deep neural network
The theory-guided neural network (TgNN) is a kind of method which improves the effectiveness and efficiency of neural network architectures by incorporating scientific knowledge or physical information. Despit...
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Article
Open AccessProximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregation
The most common inherited cause of two genetically and clinico-pathologically overlap** neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), is the presence of e...
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Article
Open AccessDe novo transcriptome analysis provides insights into the salt tolerance of Podocarpus macrophyllus under salinity stress
Soil salinization is causing ecosystem degradation and crop yield reduction worldwide, and elucidation of the mechanism of salt-tolerant plants to improve crop yield is highly significant. Podocarpus macrophyllus
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Article
Open AccessUse of proteomics to identify mechanisms of hepatocellular carcinoma with the CYP2D6*10 polymorphism and identification of ANGPTL6 as a new diagnostic and prognostic biomarker
Although an association between the cytochrome P4502D6 (CYP2D6) *10 (100C>T) polymorphism and hepatocellular carcinoma (HCC) is known, the mechanism remains unclear. Here we aimed to explore mechanisms of CYP2...
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Article
Open AccessSUMO modification in apoptosis
Apoptosis and clearance of dead cells is highly evolutionarily conserved from nematode to humans, which is crucial to the growth and development of multicellular organism. Fail to remove apoptotic cells often ...
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Article
Open AccessA Multi-Criteria Group Decision-Making Approach Based on Improved BWM and MULTIMOORA with Normal Wiggly Hesitant Fuzzy Information
Multi-criteria group decision-making (MCGDM) problems are widespread in real life. However, most existing methods, such as hesitant fuzzy set (HFS), hesitant fuzzy linguistic term set (HFLTS) and inter-valued ...
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Article
Open AccessThe MAPKKK and MAPKK gene families in banana: identification, phylogeny and expression during development, ripening and abiotic stress
The mitogen-activated protein kinase (MAPK) cascade, which is a major signal transduction pathway widely distributed in eukaryotes, has an important function in plant development and stress responses. However,...
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Article
Open AccessCross talk between miR-214 and PTEN attenuates glomerular hypertrophy under diabetic conditions
Glomerular mesangial cells (MCs) hypertrophy is one of the earliest pathological abnormalities in diabetic nephropathy (DN), which correlates with eventual glomerulosclerosis. This study aimed to investigate t...
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Article
Open AccessGenome-wide analyses of the bZIP family reveal their involvement in the development, ripening and abiotic stress response in banana
The leucine zipper (bZIP) transcription factors play important roles in multiple biological processes. However, less information is available regarding the bZIP family in the important fruit crop banana. In th...
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Article
Open AccessA rice calcium-dependent protein kinase OsCPK9 positively regulates drought stress tolerance and spikelet fertility
In plants, calcium-dependent protein kinases (CDPKs) are involved in tolerance to abiotic stresses and in plant seed development. However, the functions of only a few rice CDPKs have been clarified. At present...
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Article
Open AccessModel Order Reduction for Neutral Systems by Moment Matching
Circuits with delay elements are very popular and important in the simulation of very-large-scale integration (VLSI) systems. Neutral systems (NSs) with multiple constant delays (MCDs), for example, can be use...
