-
Article
Open AccessRituximab potentially improves clinical outcomes of CAR-T therapy for r/r B-ALL via sensitizing leukemia cells to CAR-T-mediated cytotoxicity and reducing CAR-T exhaustion
Despite chimeric antigen receptor (CAR) T-cell therapy has achieved great advances in recent year, approximately 50% of relapsed/refractory B cell acute lymphoblastic leukemia (r/r B-ALL) patients treated with...
-
Article
Open AccessATP-free in vitro biotransformation of starch-derived maltodextrin into poly-3-hydroxybutyrate via acetyl-CoA
In vitro biotransformation (ivBT) facilitated by in vitro synthetic enzymatic biosystems (ivSEBs) has emerged as a highly promising biosynthetic platform. Several ivSEBs have been constructed to produce poly-3...
-
Chapter and Conference Paper
Exploring the Establishment and Implementation of a Teaching Evaluation System Based on Value-Added Assessment
Value-added assessment (VAA) can effectively solve the existing problems of the excess of outcome-oriented evaluations and the lack of teaching evaluation feedback mechanisms in higher education, which plays a...
-
Article
Open AccessSex difference in incidence of major depressive disorder: an analysis from the Global Burden of Disease Study 2019
Major depressive disorder (MDD) is a leading mental disorder causing severe impairment. This study was aimed to evaluate sex difference in global MDD incidence by year, age, and socioeconomic status, according...
-
Article
Voltage-gated ion channels in central neurons of Helicoverpa armigera as potential targets for cycloxaprid: a cis-configuration neonicotinoid insecticide
Cycloxaprid is a novel cis-neonicotinoid, mainly acting on the nicotinic acetylcholine receptor; however, it is not clear whether cycloxaprid can act on voltage-gated ion channels. In this study, the effects of c...
-
Article
Open AccessIFN-γ-STAT1-mediated CD8+ T-cell-neural stem cell cross talk controls astrogliogenesis after spinal cord injury
Spinal cord injury (SCI) causes nearly all patients to suffer from protracted disabilities. An emerging therapeutic strategy involving the recruitment of endogenous neural stem cells (NSCs) has been developed....
-
Chapter
Biomanufacturing by In Vitro Biotransformation (ivBT) Using Purified Cascade Multi-enzymes
In vitro biotransformation (ivBT) refers to the use of an artificial biological reaction system that employs purified enzymes for the one-pot conversion of low-cost materials into biocommodities such as ethano...
-
Article
Open AccessSingle-cell transcriptome analysis reveals the immune heterogeneity and the repopulation of microglia by Hif1α in mice after spinal cord injury
Neuroinflammation is regarded as a vital pathological process in spinal cord injury (SCI), which removes damaged tissue, secretes cytokines, and facilitates regeneration. Repopulation of microglia has been sho...
-
Article
Open AccessGrowing prevalence of heat over cold extremes with overall milder extremes and multiple successive events
Temperature extremes with altered characteristics are one of the most threatening impacts of global warming. How their characteristics have changed is uncertain, and varies by region. Here we analyse ERA5 rean...
-
Article
Open AccessCD157 in bone marrow mesenchymal stem cells mediates mitochondrial production and transfer to improve neuronal apoptosis and functional recovery after spinal cord injury
Recent studies demonstrated that autologous mitochondria derived from bone marrow mesenchymal stem cells (BMSCs) might be valuable in the treatment of spinal cord injury (SCI). However, the mechanisms of mitoc...
-
Article
Electrochemical aptasensor based on Mo2C/Mo2N and gold nanoparticles for determination of chlorpyrifos
Two-dimensional Mo2C/Mo2N composites were synthesized by high temperature ball milling and used as support materials for fabricating a chlorpyrifos (CPF) aptasensor. Gold nanoparticles (Au NPs) were electrodeposi...
-
Article
An ATP-free in vitro synthetic enzymatic biosystem facilitating one-pot stoichiometric conversion of starch to mannitol
D-Mannitol (hereinafter as mannitol) is a six-carbon sugar alcohol with diverse applications in food and pharmaceutical industries. To overcome the drawbacks of the chemical hydrogenation method commonly used ...
-
Article
SCFAs induce autophagy in intestinal epithelial cells and relieve colitis by stabilizing HIF-1α
Hypoxia-inducible factor-1α (HIF-1α) is a critical regulator of barrier integrity during colonic mucosal injury. Previous works have shown that the absence of autophagy is implicated in the development of infl...
-
Article
Deep convolutional representations and kernel extreme learning machines for image classification
Convolutional Neural Networks (CNNs) have been established as a powerful class of models for image classification and related tasks. However, the fully-connected layers in CNN are not robust enough to serve as...
-
Article
Open AccessCharacterization of a hyperthermophilic phosphatase from Archaeoglobus fulgidus and its application in in vitro synthetic enzymatic biosystem
Haloacid dehalogenase (HAD)-like hydrolases represent the largest superfamily of phosphatases, which release inorganic phosphate from phosphate containing compounds, such as sugar phosphates. The HAD-like phos...
-
Article
Land use and land cover classification using Chinese GF-2 multispectral data in a region of the North China Plain
The newly launched GF-2 satellite is now the most advanced civil satellite in China to collect high spatial resolution remote sensing data. This study investigated the capability and strategy of GF-2 multispec...
-
Chapter and Conference Paper
Attention-Aware Invertible Hashing Network
In large-scale image retrieval tasks, hashing methods based on deep convolutional neural networks (CNNs) play an important role due to elaborate semantic feature representation. However, they usually progressi...
-
Chapter and Conference Paper
Deep Super-Resolution Hashing Network for Low-Resolution Image Retrieval
In image retrieval, deep learning based hashing approaches have achieved promising performance in recent years. However, they are usually trained on a specific resolution, so it will cause unpleasant retrieval...
-
Chapter
Blue Ocean Strategy® in China—Successful Examples in E-Commerce
The objective of this article is to analyze the Blue Ocean Strategy® in China, especially in e-commerce. This contribution mainly focuses on four e-commerce companies by analyzing their business-models and develo...
-
Article
AhR activation protects intestinal epithelial barrier function through regulation of Par-6
The Par complex (Par-6/Par-3/aPKC) plays a key role in the maintenance of the intestinal barrier function through the regulation of epithelial junction formation. The aryl hydrocarbon receptor (AhR) has been s...
