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Article
Open AccessCentralized industrialization of pork in Europe and America contributes to the global spread of Salmonella enterica
Salmonella enterica causes severe food-borne infections through contamination of the food supply chain. Its evolution has been associated with human activities, especially animal husbandry. Advances in intensive ...
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Article
Open AccessHeterogeneous changes in gut and tumor microbiota in patients with pancreatic cancer: insights from clinical evidence
Pancreatic cancer is the foremost contributor to cancer-related deaths globally, and its prevalence continues to rise annually. Nevertheless, the underlying mechanisms behind its development remain unclear and...
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Article
Frequency-domain characteristic analysis of PCNN
The pulse-coupled neural network (PCNN) is widely used in digital image processing. Although existing studies mainly analyze the network from the time-domain perspective, there are still some limitations in re...
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Article
Open AccessHPV-associated cervicovaginal microbiome and host metabolome characteristics
Cervicovaginal microbiome plays an important role in the persistence of HPV infection and subsequent disease development. However, cervicovaginal microbiota varied cross populations with different habits and r...
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Article
Open AccessDownregulation of lncRNA CDKN2B-AS1 attenuates inflammatory response in mice with allergic rhinitis by regulating miR-98-5p/SOCS1 axis
Long non-coding RNA cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) in various diseases has been verified. However, the underlying mechanism of CDKN2B-AS1 contributes to the development of al...
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Article
Prediction of Depth-Averaged Velocity for Flow Though Submerged Vegetation Using Least Squares Support Vector Machine with Bayesian Optimization
Considering the limited accuracy of classical empirical formulas and traditional Machine Learning (ML) models for predicting the depth-averaged velocity of flow through submerged vegetation, in this article, a...
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Article
Open AccessDistributed genoty** and clustering of Neisseria strains reveal continual emergence of epidemic meningococcus over a century
Core genome multilocus sequence ty** (cgMLST) is commonly used to classify bacterial strains into different types, for taxonomical and epidemiological applications. However, cgMLST schemes require central da...
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Article
Open AccessStructural basis for the activation of a compact CRISPR-Cas13 nuclease
The CRISPR-Cas13 ribonucleases have been widely applied for RNA knockdown and transcriptional modulation owing to their high programmability and specificity. However, the large size of Cas13 effectors and thei...
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Article
Open AccessComparative genomics unveils extensive genomic variation between populations of Listeria species in natural and food-associated environments
Comprehending bacterial genomic variation linked to distinct environments can yield novel insights into mechanisms underlying differential adaptation and transmission of microbes across environments. Gaining s...
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Article
Open AccessAssociation between total cholesterol and total bone mineral density in US adults: National Health and Nutrition Examination Survey (NHANES), 2011–2018
Accumulated evidence indicates that cholesterol is offensive to bone metabolism. Therefore, we examined the real-world study among total cholesterol and total bone mineral density (BMD). We investigated the re...
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Article
Engineered LwaCas13a with enhanced collateral activity for nucleic acid detection
Clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated protein 13 (Cas13) has been rapidly developed for nucleic-acid-based diagnostics by using its characteristic collateral acti...
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Article
Open AccessA novel prognostic model for cutaneous melanoma based on an immune-related gene signature and clinical variables
Abundant evidence has indicated that the prognosis of cutaneous melanoma (CM) patients is highly complicated by the tumour immune microenvironment. We retrieved the clinical data and gene expression data of CM...
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Article
Correction to: PCNN double step firing mode for image edge detection
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PCNN double step firing mode for image edge detection
Pulse-coupled Neural Network (PCNN) is a third-generation artificial neural network that requires no training. Neurons in PCNN have two pulse burst modes: firing mode and fire-extinguishing mode. A lot of rese...
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Article
Aggregated pyramid attention network for mass segmentation in mammograms
Intra-class inconsistency and inter-class indistinction are intractable problems that commonly exist in breast mass segmentation from mammograms. In this work, a novel deep learning segmentation model is prese...
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Open AccessSelf-directed online machine learning for topology optimization
Topology optimization by optimally distributing materials in a given domain requires non-gradient optimizers to solve highly complicated problems. However, with hundreds of design variables or more involved, s...
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Article
A Comprehensive Overview of Image Enhancement Techniques
Image enhancement plays an important role in improving image quality in the field of image processing, which is achieved by highlighting useful information and suppressing redundant information in the image. I...
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Adaptive channel and multiscale spatial context network for breast mass segmentation in full-field mammograms
Breast cancer is currently the second most fatal cancer in women, but timely diagnosis and treatment can reduce its mortality. Breast masses are the most obvious means of cancer identification, and thus, accur...
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Article
Open AccessGlobal spread of Salmonella Enteritidis via centralized sourcing and international trade of poultry breeding stocks
A pandemic of Salmonella enterica serotype Enteritidis emerged in the 1980s due to contaminated poultry products. How Salmonella Enteritidis rapidly swept through continents remains a historical puzzle as the pat...
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Article
Experimental investigation and viscoelastic-plastic model for sandstone under cyclic tensile stress
Abandoned roadways of coal mines are suitable for compressed air energy storage after proper treatment with grouting reinforcement and concrete lining. According to the theoretical analysis, the rock mass and ...
