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Article
Big Hankel operators on Hardy spaces of strongly pseudoconvex domains
In this article, we investigate the (big) Hankel operator Hf on the Hardy spaces of bounded strongly pseudoconvex domains Ω in ℂn. We observe that Hf is bounded on Hp (Ω) (1 < p < ∞) if f belongs to BMO and we ob...
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Article
Open AccessABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism
ABCA7 loss-of-function variants are associated with increased risk of Alzheimer’s disease (AD). Using ABCA7 knockout human iPSC models generated with CRISPR/Cas9, we investigated the impacts of ABCA7 deficiency o...
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Article
Open AccessLarge-scale genomic rearrangements boost SCRaMbLE in Saccharomyces cerevisiae
Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution (SCRaMbLE) is a promising tool to study genomic rearrangements. However, the potential of SCRaMbLE to study genomic rearrangements...
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Article
Open AccessBuilding a eukaryotic chromosome arm by de novo design and synthesis
The genome of an organism is inherited from its ancestor and continues to evolve over time, however, the extent to which the current version could be altered remains unknown. To probe the genome plasticity of Sac...
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Article
Open AccessPotentiation of apoptosis in drug-resistant mantle cell lymphoma cells by MCL-1 inhibitor involves downregulation of inhibitor of apoptosis proteins
Bruton’s tyrosine kinase inhibitors (BTKi) and CAR T-cell therapy have demonstrated tremendous clinical benefits in mantle cell lymphoma (MCL) patients, but intrinsic or acquired resistance inevitably develops...
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Article
Primary assessment of the diversity of Omicron sublineages and the epidemiologic features of autumn/winter 2022 COVID-19 wave in Chinese mainland
With the recent ongoing autumn/winter 2022 COVID-19 wave and the adjustment of public health control measures, there have been widespread SARS-CoV-2 infections in Chinese mainland. Here we have analyzed 369 vi...
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Article
Open AccessThe Omicron BA.2.2.1 subvariant drove the wave of SARS-CoV-2 outbreak in Shanghai during spring 2022
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Article
Open AccessTIGIT is the central player in T-cell suppression associated with CAR T-cell relapse in mantle cell lymphoma
Chimeric antigen receptor (CAR) T-cell therapy using brexucabtagene autoleucel (BA) induces remission in many patients with mantle cell lymphoma (MCL), and BA is the only CAR T-cell therapy approved by the FDA...
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Article
Efficient de novo assembly and modification of large DNA fragments
Synthetic genomics has provided new bottom-up platforms for the functional study of viral and microbial genomes. The construction of the large, gigabase (Gb)-sized genomes of higher organisms will deepen our u...
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Article
Open AccessTargeting FcγRIIB by antagonistic antibody BI-1206 improves the efficacy of rituximab-based therapies in aggressive mantle cell lymphoma
Inevitable relapses remain as the major therapeutic challenge in patients with mantle cell lymphoma (MCL) despite FDA approval of multiple targeted therapies and immunotherapies. Fc gamma receptors (FcγRs) pla...
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Article
Open AccessThe antibody drug conjugate VLS-101 targeting ROR1 is effective in CAR T-resistant mantle cell lymphoma
Mantle cell lymphoma (MCL) is a rare, aggressive and incurable subtype of non-Hodgkin’s B-cell lymphoma. The principal barrier is frequent clinical relapse to multiple lines of therapies, including new FDA-app...
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Article
Open AccessIntegrating longitudinal clinical laboratory tests with targeted proteomic and transcriptomic analyses reveal the landscape of host responses in COVID-19
The pathophysiology of coronavirus disease 19 (COVID-19) involves a multitude of host responses, yet how they unfold during the course of disease progression remains unclear. Here, through integrative analysis...
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Article
Response of activity and community composition of nitrite-oxidizing bacteria to partial substitution of chemical fertilizer by organic fertilizer
Nitrite oxidation as the second step of nitrification can become the determining step in disturbed soil systems. As a beneficial fertilization practice to maintain high crop yield and soil fertility, partial s...
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Article
Open AccessLongitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma
The mechanisms driving therapeutic resistance and poor outcomes of mantle cell lymphoma (MCL) are incompletely understood. We characterize the cellular and molecular heterogeneity within and across patients an...
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Article
Open AccessCompacting a synthetic yeast chromosome arm
Redundancy is a common feature of genomes, presumably to ensure robust growth under different and changing conditions. Genome compaction, removing sequences nonessential for given conditions, provides a novel ...
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Protocol
Chromosomal Rearrangements of Synthetic Yeast by SCRaMbLE
Diversified genomes derived from chromosomal rearrangements are valuable materials for evolution. Naturally, chromosomal rearrangements occur at extremely low frequency to ensure genome stability. In the synth...
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Protocol
Use YeastFab to Construct Genetic Parts and Multicomponent Pathways for Metabolic Engineering
Budding yeast, as a eukaryotic model organism, has well-defined genetic information and a highly efficient recombination system, making it a good host to produce exogenous chemicals. Since most metabolic pathw...
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Article
Open AccessSc3.0: revam** and minimizing the yeast genome
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Article
Toeplitz Operators Associated with Measures and the Dixmier Trace on the Hardy Space
Let \(\mu \)μ be a regular Borel measure on the open unit ball B in \(\mathbf{C}^n\)Cn. By a natural formula, it gives rise to a Toeplitz operator \(T_\mu \)Tμ on the Hardy space \(H^2(S)\)H2(S). We characterize ...
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Open AccessRepurposing auranofin to treat TP53-mutated or PTEN-deleted refractory B-cell lymphoma
