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Article
On the migrativity properties between uni-nullnorms and overlap (grou**) functions
Based on the concepts of the \(\alpha \) α -migrativity between overlap (grou**) functions...
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Article
OptADMET: a web-based tool for substructure modifications to improve ADMET properties of lead compounds
Lead optimization is a crucial step in the drug discovery process, which aims to design potential drug candidates from biologically active hits. During lead optimization, active hits undergo modifications to i...
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Article
Open AccessWGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis
Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a major impediment to its clinical application. It is indispensable to explore alternative treatment molecules or drugs for mitigating DIC. WGX50, an organic e...
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Article
Open AccessRetrosynthesis prediction with an interpretable deep-learning framework based on molecular assembly tasks
Automating retrosynthesis with artificial intelligence expedites organic chemistry research in digital laboratories. However, most existing deep-learning approaches are hard to explain, like a “black box” with...
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Article
Significant efficacy of short-course, low-concentration betamethasone mouthwash therapy for severe erosive oral lichen planus: a randomized controlled trial
To evaluate the short-term efficacy of low-concentration betamethasone mouthwash for severe erosive oral lichen planus (EOLP).
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Article
Open AccessPharmacophoric-constrained heterogeneous graph transformer model for molecular property prediction
Informative representation of molecules is a crucial prerequisite in AI-driven drug design and discovery. Pharmacophore information including functional groups and chemical reactions can indicate molecular pro...
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Article
Open AccessDeep generative model for drug design from protein target sequence
Drug discovery for a protein target is a laborious and costly process. Deep learning (DL) methods have been applied to drug discovery and successfully generated novel molecular structures, and they can substan...
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Article
Monodirectional evolutional symport tissue P systems with channel states and cell division
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Chapter and Conference Paper
Factors Influencing Social Media Forgiveness Behavior and Cyber Violence Tendency Among Chinese Youth: Moderating Effects of Forgiveness Climate and Risk Perception
Over the past years, the issue of cyber violence has gradually become a key focus of social media studies. Most previous studies of cyber violence in social media have focused on superficial behaviors, with le...
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Article
Accurate prediction of molecular properties and drug targets using a self-supervised image representation learning framework
The clinical efficacy and safety of a drug is determined by its molecular properties and targets in humans. However, proteome-wide evaluation of all compounds in humans, or even animal models, is challenging. ...
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Article
Open AccessTGF-β signaling in the tumor metabolic microenvironment and targeted therapies
Transforming growth factor-β (TGF-β) signaling has a paradoxical role in cancer progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in the late stages of cancer. Once cancer...
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Article
Open AccessMultiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2
The Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a global pandemic that seriously threatens health and socioeconomic development, but the existe...
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Article
Open AccessHigh density lipoprotein inhibited group II innate lymphoid cells proliferation and function in allergic rhinitis
More and more studies had suggested that dyslipidemia was closely related to allergic diseases. High density lipoprotein (HDL) often plays anti-inflammatory and anti-oxidative roles by suppressing immune cell ...
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Article
Open AccessTGF-βRII regulates glucose metabolism in oral cancer-associated fibroblasts via promoting PKM2 nuclear translocation
Cancer-associated fibroblasts (CAFs) are highly heterogeneous and differentiated stromal cells that promote tumor progression via remodeling of extracellular matrix, maintenance of stemness, angiogenesis, and ...
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Chapter and Conference Paper
Research on Vibration Index of IRI Detection Based on Smart Phone
With the development of science and technology, intelligent pavement smoothness detection becomes possible. Intelligent IRI (International Roughness Index) detection is one of the important development directi...
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Article
Natural methionine-passivated MAPbI3 perovskite films for efficient and stable solar devices
Defects located at the surfaces and grain boundaries of solution-processed perovskite films serve as nonradiative recombination centers and are detrimental for the photovoltaic performance of solar devices. He...
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Article
Solving a PSPACE-complete problem by symport/antiport P systems with promoters and membrane division
Symport/antiport P systems with membrane division are parallel computing models, which can solve NP-complete problems in polynomial time. In this paper, promoters are incorporated into symport/antiport P systems ...
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Article
Nano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety
Chimeric antigen receptor (CAR) T cell-based immunotherapy, approved by the US Food and Drug Administration, has shown curative potential in patients with haematological malignancies. However, owing to the lac...
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Article
Open AccessSignaling pathways in cancer-associated fibroblasts and targeted therapy for cancer
To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME), and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and progression because of their versat...
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Article
Open AccessCarSite-II: an integrated classification algorithm for identifying carbonylated sites based on K-means similarity-based undersampling and synthetic minority oversampling techniques
Carbonylation is a non-enzymatic irreversible protein post-translational modification, and refers to the side chain of amino acid residues being attacked by reactive oxygen species and finally converted into c...
