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Article
A label-free and rapid fluorometric strategy for microRNA detection using CRISPR-Cas12a coupled with copper nanoparticles
CRISPR-Cas12a with robust trans-cleavage activity were employed to mitigate background fluorescence signal, achieving sensitive detection of miRNA-21. The activation of trans-cleavage activity of Cas12a was ac...
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Article
Open AccessCross-modal learning using privileged information for long-tailed image classification
The prevalence of long-tailed distributions in real-world data often results in classification models favoring the dominant classes, neglecting the less frequent ones. Current approaches address the issues in ...
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Article
Investigation of crystal habit of N,N′-dicyclohexylterephthalamide and its influence on the crystallization behavior of isotactic polypropylene
In this paper, the N,N′-dicyclohexylterephthalamide (DCHT) with various morphologies and sizes was prepared by antisolvent precipitation at room temperature, and DCHT single crystals were also grown. Among them, ...
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Article
Open AccessRBM10 C761Y mutation induced oncogenic ASPM isoforms and regulated β-catenin signaling in cholangiocarcinoma
Cholangiocarcinoma (CCA) comprises a heterogeneous group of biliary tract cancer. Our previous CCA mutation pattern study focused on genes in the post-transcription modification process, among which the altern...
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Article
Open AccessAdvanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop
The meniscus is vital for maintaining knee homeostasis and function. Meniscal calcification is one of the earliest radiological indicators of knee osteoarthritis (KOA), and meniscal calcification is associated...
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Article
Open AccessCircPCNXL2 promotes tumor growth and metastasis by interacting with STRAP to regulate ERK signaling in intrahepatic cholangiocarcinoma
circular RNAs (circRNAs) have been reported to exert important effects in the progression of numerous cancers. However, the functions of circRNAs in intrahepatic cholangiocarcinoma (ICC) are still unclear.
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Article
Open AccessSynthesis of UV-resistant and colorless polyimide films for optoelectrical applications
Due to their excellent mechanical properties and intrinsic flexibility, polyimides (PIs) are promising candidates for optoelectrical applications under harsh conditions such as flexible organic solar cells as ...
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Article
Enhanced corrosion resistance of flaky carbonyl iron through dual silane surface modification for the application of electromagnetic wave absorption coatings
Surface modifications are efficient techniques to enhance the corrosion resistance of flaky carbonyl iron (FCI) for electromagnetic wave absorbing coatings. However, with the emergence of diverse harsh service...
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Article
Prediction of cutting force via machine learning: state of the art, challenges and potentials
Cutting force is a critical factor that reflects the machining states and affects tool wear, cutting stability, and the quality of the machined surface. Accurate prediction of cutting force has been the subjec...
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Article
Open AccessThe machinability of titanium alloy thin-wall parts in cooling minimum quantity lubrication (CMQL) environments
The machining of thin-wall components made of titanium alloys is challenging because the poor machinability of the material leads to severe problems such as accelerated tool wear and poor surface quality, whil...
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Article
Open AccessEfficient Electromagnetic Wave Absorption and Thermal Infrared Stealth in PVTMS@MWCNT Nano-Aerogel via Abundant Nano-Sized Cavities and Attenuation Interfaces
PVTMS@MWCNT nano-aerogel with nano-pore size and abundant heterogeneous interface was fabricated via radical polymerization, sol–gel transition and CO2 drying.
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Article
MAD2 activates IGF1R/PI3K/AKT pathway and promotes cholangiocarcinoma progression by interfering USP44/LIMA1 complex
Spindle assembly checkpoint (SAC) plays an essential part in facilitating normal cell division. However, the clinicopathological and biological significance of mitotic arrest deficient 2 like 1 (MAD2/MAD2L1), ...
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Article
Open AccessHypoxia-induced SKA3 promoted cholangiocarcinoma progression and chemoresistance by enhancing fatty acid synthesis via the regulation of PAR-dependent HIF-1a deubiquitylation
Spindle and kinetochore-associated complex subunit 3 (SKA3) plays an important role in cell proliferation by regulating the separation of chromosomes and their division into daughter cells. Previous studies de...
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Article
Open AccessACSL4 serves as a novel prognostic biomarker correlated with immune infiltration in Cholangiocarcinoma
Cholangiocarcinoma (CHOL) is the second most common primary hepatic malignant tumor, following hepatocellular carcinoma (HCC). CHOL is highly aggressive and heterogeneous resulting in poor prognosis. The diagn...
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Article
KIF14 promotes proliferation, lymphatic metastasis and chemoresistance through G3BP1/YBX1 mediated NF-κB pathway in cholangiocarcinoma
Cholangiocarcinoma (CCA), a highly lethal and fetal cancer derived from the hepatobiliary system, is featured by aggressive growth and early lymphatic metastasis. Elucidating the underlying mechanism and ident...
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Article
After-hour elective total knee arthroplasty does not affect clinical outcomes but negatively affects alignment
In cases of limited medical resources, elective total knee arthroplasty (TKA) sometimes needs to be performed after typical work hours. However, surgeon fatigue and logistical factors may potentially affect ou...
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Article
Research on determining the position of zero optical path difference with the wavelet transform
Due to the error of digital sampling, there is a deviation between the zero optical path difference (ZOPD) detection position of the interference signal in the infrared gas analyzer and the actual position. To...
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Chapter and Conference Paper
Meta-Causal Feature Learning for Out-of-Distribution Generalization
Causal inference has become a powerful tool to handle the out-of-distribution (OOD) generalization problem, which aims to extract the invariant features. However, conventional methods apply causal learners fro...
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Chapter and Conference Paper
Unsupervised Segmentation of Haze Regions as Hard Attention for Haze Classification
Haze classification plays a crucial role in air quality and visibility assessment. In contrast to traditional image classification, haze classification requires the classifier to capture the characteristics of...
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Article
Enhancement of electrical conductivity and electromagnetic interference shielding performance via supercritical CO2 induced phase coarsening for double percolated polymer blends
The electrical conductivity of conductive polymer composites (CPCs) with a classical double percolated structure is highly connected to the phase morphology. However, lots of conductive fillers, which are adde...
