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Article
Open AccessRadiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8+ T and NK cells
Immunosuppression by the tumor microenvironment is a pivotal factor contributing to tumor progression and immunotherapy resistance. Priming the tumor immune microenvironment (TIME) has emerged as a promising s...
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Article
Association of Exposure to Heavy Metal Mixtures with Systemic Immune-Inflammation Index Among US Adults in NHANES 2011–2016
In reality, people are often co-exposed to multiple heavy metals; however, current research has focused on the association between individual heavy metals and inflammation. Therefore, it is more relevant to ex...
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Article
Open AccessA Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2 replication
The ORF9b protein, derived from the nucleocapsid’s open-reading frame in both SARS-CoV and SARS-CoV-2, serves as an accessory protein crucial for viral immune evasion by inhibiting the innate immune response. ...
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Article
Seismic performance of a new type of prefabricated bridge pier with cast-in-place UHPC jacketing
Accelerated bridge construction (ABC) is prevalent all over the world attributable to its technical advantages including the higher construction efficiency, less traffic disruption, and higher construction qua...
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Article
A review of microwave–metal discharge interaction: Mechanism, regulation, and application for synthesis of nanomaterials
Placing metals within microwave ovens has been generally viewed as a dangerous practice because of occurrence of violent discharge, but in recent years such discharge phenomenon has attracted increasing attent...
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Article
Open AccessInitial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection
The immunoprotective components control COVID-19 disease severity, as well as long-term adaptive immunity maintenance and subsequent reinfection risk discrepancies across initial COVID-19 severity, remain uncl...
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Article
Open AccessTargeting senescent cells with NKG2D-CAR T cells
This study investigates the efficacy of NKG2D chimeric antigen receptor (CAR) engineered T cells in targeting and eliminating stress-induced senescent cells in vitro. Cellular senescence contributes to age-rel...
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Article
Open AccessSurvival benefit of radical prostatectomy in patients with advanced TURP-diagnosed prostate cancer: a population-based real-world study
A considerable number of patients are diagnosed with prostate cancer (PCa) by transurethral resection of the prostate (TURP). We aimed to evaluate whether radical prostatectomy (RP) brings survival benefits fo...
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Article
Targeting dysregulated phago-/auto-lysosomes in Sertoli cells to ameliorate late-onset hypogonadism
Age-related changes in testicular function can impact health and well-being. The mechanisms underlying age-related testicular dysfunction, such as late-onset hypogonadism (LOH), remain incompletely understood....
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Article
A spatiotemporal atlas of cholestatic injury and repair in mice
Cholestatic liver injuries, characterized by regional damage around the bile ductular region, lack curative therapies and cause considerable mortality. Here we generated a high-definition spatiotemporal atlas ...
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Article
Synergistic effects of multiscale TiC and dual-phase structure on tensile properties of particle-reinforced steel
The conventional melting methods were used to obtain in situ TiC particle-reinforced dual-phase steel, followed by hot rolling and heat treatment processes. The aim was to investigate the effect of TiC particl...
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Article
Open AccessAlterations in the fecal microbiota of methamphetamine users with bad sleep quality during abstinence
Methamphetamine (MA) abuse has resulted in a plethora of social issues. Sleep disturbance is a prominent issue about MA addiction, which serve as a risk factor for relapse, and the gut microbiota could play an...
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Article
Atomic-Scale Insights into Damage Mechanisms of GGr15 Bearing Steel Under Cyclic Shear Fatigue
Alternating shear stress is a critical factor in the accumulation of damage during rolling contact fatigue, severely limiting the service life of bearings. However, the specific mechanisms responsible for the ...
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Article
Characteristics of multi-channel reservoir computing based on mutually-coupled spin-VCSELs: a comprehensive investigation
We studied the characteristics of a four-channel multi-task reservoir computing (RC) system based on mutually-coupled and optically pumped spin vertical-cavity surface-emitting lasers (Spin-VCSELs). By analyzi...
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Article
Open AccessMex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy
RNA-binding proteins (RBPs)-RNA networks have contributed to cancer development. Circular RNAs (circRNAs) are considered as protein recruiters; nevertheless, the patterns of circRNA-protein interactions in col...
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Article
Associations of slee** patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults
Studies have found a U-shaped relationship between sleep duration and chronic kidney disease (CKD) risk, but limited research evaluated the association of reallocating excessive sleep to other behavior with CK...
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Article
Open AccessEffect of use of NSAIDs or steroids during the acute phase of pain on the incidence of chronic pain: a systematic review and meta-analysis of randomised trials
This study is the first to summarize the evidence on how the use of anti-inflammatory drugs during acute pain has an impact on the development of chronic pain.
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Article
Research progress of electrolytic treatment technology for organic wastewater
Advanced oxidation technologies (AOPs) are efficient and environmentally friendly methods primarily used for removing persistent organic pollutants (POPs) from industrial wastewater. Traditional wastewater tre...
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Article
Open AccessTGF-β signaling in health, disease, and therapeutics
Transforming growth factor (TGF)-β is a multifunctional cytokine expressed by almost every tissue and cell type. The signal transduction of TGF-β can stimulate diverse cellular responses and is particularly cr...
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Article
Open AccessThe construction of modular universal chimeric antigen receptor T (MU-CAR-T) cells by covalent linkage of allogeneic T cells and various antibody fragments
Chimeric antigen receptor-T (CAR-T) cells therapy is one of the novel immunotherapeutic approaches with significant clinical success. However, their applications are limited because of long preparation time, h...
