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Article
Association between triglyceride-glucose index and endothelial dysfunction
Triglyceride-glucose (TyG) index, a simple surrogate marker for insulin resistance (IR), has been reported as an independent predictor of arterial structural damage and future cardiovascular events. The associ...
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Article
A Chinese case of CHST3-related skeletal dysplasia and a systematic review
We reported a case with carbohydrate sulfotransferase 3 (CHST3) spondyloepiphyseal dysplasia and made a systematic review of all previously reported cases.
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Article
Identification of two potential immune-related biomarkers of Graves’ disease based on integrated bioinformatics analyses
Graves’ disease (GD) is an autoimmune disease, the incidence of which is increasing yearly. GD requires long-life therapy. Therefore, the potential immune-related biomarkers of GD need to be studied.
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Article
Long-term outcomes and prognostic factors in papillary thyroid microcarcinoma patients with distant metastases
Distant metastasis from papillary thyroid microcarcinoma (PTMC) is extremely rare and the long-term outcomes and independent prognostic factors remain unclear. The present study aimed to investigate clinicopat...
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Article
Quantitative proteomics revealed the molecular characteristics of distinct types of granulated somatotroph adenomas
Somatotroph adenomas are obviously heterogeneous in clinical characteristics, imaging performance, pathological diagnosis and therapeutic effect. The heterogeneity of the tumors, especially for SG and DG type ...
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Article
Development and validation of a novel diagnostic nomogram model to predict primary aldosteronism in patients with hypertension
Primary aldosteronism (PA) remains, to a large extent, an under-diagnosed disease. We aimed to develop and validate a novel clinical nomogram to predict PA based on routine biochemical variables including new ...
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Article
Low LDL-C levels are associated with risk of mortality in a Chinese cohort study
Although low-density lipoprotein cholesterol (LDL-C) has been considered as a risk factor of atherosclerotic cardiovascular disease, limited studies can be available to evaluate the association of LDL-C with r...
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Article
Do reductions in risk of cardiorenal events with SGLT2 inhibitors in type 2 diabetes vary with baseline characteristics? A meta-analysis
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Article
Serum complement C3 and islet β-cell function in patients with type 2 diabetes: A 4.6-year prospective follow-up study
Serum complement C3 has been shown to contribute to the incidence of type 2 diabetes (T2D), but how serum complement C3 affects islet β-cell function throughout the course of T2D is unclear. This study explore...
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Article
Open AccessGlycemic variation in uncontrolled Graves’ disease patients with normal glucose metabolism: Assessment by continuous glucose monitoring
To observe the glycemic variation (GV) in uncontrolled Graves’ disease (GD) patients with normal glucose metabolism measured by continuous glucose monitoring (CGM).
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Article
Liraglutide induces beige fat development and promotes mitochondrial function in diet induced obesity mice partially through AMPK-SIRT-1-PGC1-α cell signaling pathway
Glucagon like peptide-1 (GLP-1) is produced to induce postprandial insulin secretion. Liraglutide, a full agonist of the GLP-1 receptor, has a protective effect on weight gain in obese subjects. Brown adipose ...
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Article
Effects of combined menaquinone-4 and PTH1–34 treatment on osetogenesis and angiogenesis in calvarial defect in osteopenic rats
The aim of this study was to evaluate the effect of combining human parathyroid hormone (1–34) (PTH1–34; PTH) and menaquinone-4 (MK-4) on calvarial bone defect repair in osteopenic rats.
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Article
Ectopic thyroids have lower computed tomography attenuation values than orthotopic thyroids
To determine whether ectopic thyroid had the same computed tomography (CT) value as orthotopic thyroid.
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Article
High-normal serum thyrotropin levels and increased glycemic variability in type 2 diabetic patients
High-normal thyrotropin (TSH) is related to reduced insulin sensitivity and may contribute to glycemic disorders in diabetes. We investigated the relationship between normal serum TSH levels and glycemic varia...
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Article
Association of glycaemic variability evaluated by continuous glucose monitoring with diabetic peripheral neuropathy in type 2 diabetic patients
Diabetic peripheral neuropathy (DPN), a common microvascular complication of diabetes, is linked to glycaemic derangements. Glycaemic variability, as a pattern of glycaemic derangements, is a key risk factor f...
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Article
Association between fibroblast growth factor 21 and bone mineral density in adults
Animal-based studies have reported a decrease in bone mass resulting from high level of fibroblast growth factor 21 (FGF21). However, the correlation between plasma FGF21 levels and bone mineral density (BMD) ...
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Article
Radiofrequency ablation vs. microwave ablation for patients with benign thyroid nodules: a propensity score matching study
To compare the efficacy and the safety of radiofrequency ablation and microwave ablation for treatment of benign thyroid nodules using a propensity score matching study design.
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Article
Maternal TSH level and TPOAb status in early pregnancy and their relationship to the risk of gestational diabetes mellitus
Subclinical hypothyroidism is common in pregnant women and often related to adverse pregnancy outcomes, but its relationship with gestational diabetes remains controversial. In particular, the impact of thyrop...
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Article
Calcitriol attenuates cardiac remodeling and dysfunction in a murine model of polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is a complex reproductive and metabolic disorder affecting 10 % of reproductive-aged women, and is well associated with an increased prevalence of cardiovascular risk factors. ...
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Article
Long-lasting anti-diabetic efficacy of PEGylated FGF-21 and liraglutide in treatment of type 2 diabetic mice
Fibroblast growth factor-21 (FGF-21) is a new member of the FGF family and potential drug candidate for the treatment of type 2 diabetes mellitus. However, FGF-21 protein has short half-life in vivo, which sev...