65 Result(s)
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**ang-Jun Lu
Biomedicine, general
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Article
Inhibitory effects of jujuboside A on EEG and hippocampal glutamate in hyperactive rat
In this study, the inhibitory effect of jujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG (electroencephalogram) and the concentration of hippocampal...
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Article
Phosphorylated heat shock protein 27 is involved in enhanced heart tolerance to ischemia in short-term type 1 diabetic rats
To examine the tolerance of type 1 diabetic hearts to ischemia and reperfusion injury. Myocardial contents of 27-kDa and 70-kDa heat shock proteins (hsp) as well as phosphorylated hsp27 were also determined.
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Article
GLB prevents tumor metastasis of Lewis lung carcinoma by inhibiting tumor adhesion actions
To investigate the inhibitory effect of a new compound of GLB on tumor metastasis in vivo and analyze its actions on tumor cell adhesion to clarify its mechanism.
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Article
Propofol attenuates oxidative stress-induced PC12 cell injury via p38 MAP kinase dependent pathway
To investigate the neuroprotective effect of propofol and its intracellular mechanism on neurons in vitro.
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Article
A preliminary study on the teratogenesis of dexamethasone and the preventive effect of vitamin B12 on murine embryonic palatal shelf fusion in vitro
Excessive dexamethasone (Dex) administrated into pregnant mice during critical periods of palatal development can produce a high incidence of cleft palate. Its mechanisms remain unknown. Vitamin B12 has been show...
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Article
Open AccessmRNA expression of the DNA replication-initiation proteins in epithelial dysplasia and squamous cell carcinoma of the tongue
The tongue squamous cell carcinomas (SCCs) are characterized by high mitotic activity, and early detection is desirable. Overexpression of the DNA replication-initiation proteins has been associated with dyspl...
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Article
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21
Xuejun Zhang and colleagues report a genome-wide association and replication studies for psoriasis, conducted in Chinese populations. They confirm previous associations in MHC and IL12B to psoriasis susceptibilit...
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Article
Polyclonal antibodies to LIM proteins CRP2 and CRIP2 reveal their subcellular localizations in olfactory precursor cells
In this study, we describe the presence of CRP2 (cysteine- and glycine-rich protein 2) and CRIP2 (cysteine-rich intestinal protein 2), which are members of group 2 LIM proteins, in rat olfactory precursor cell...
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Article
Effects of sevoflurane preconditioning and postconditioning on rat myocardial stunning in ischemic reperfusion injury
Ischemic preconditioning and postconditioning distinctly attenuate ventricular arrhythmia after ischemia without affecting the severity of myocardial stunning. Therefore, we report the effects of sevoflurane p...
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Article
Evaluation of a risk factor scoring model in screening for undiagnosed diabetes in China population
To develop a risk scoring model for screening for undiagnosed type 2 diabetes in Chinese population.
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Article
The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
Sensors of cytosolic nucleic acid can detect the presence of viruses. Liu and colleagues identify the helicase DDX41 as a sensor of double-stranded DNA that initiates upregulation of type I interferon dependen...
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Article
Regulation of angiotensin-(1–7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure
To investigate the possible effects of telmisartan and losartan on cardiac function in adriamycin (ADR)-induced heart failure in rats, and to explore the changes in plasma level of angiotensin-(1–7)[Ang-(1–7)]...
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Article
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2
Dai Zhang and colleagues report a genome-wide association study for schizophrenia in the Han Chinese population. They identify a new susceptibility locus at 11p11.2 and also identify a locus at 6p21-22.1 in th...
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Article
Correction: Corrigendum: The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
Nat. Immunol. 12, 959–965 (2011); published online 4 September 2011; corrected after print 17 November 2011. In the version of this article initially published, the sensor DDX41 was suggested to recognize Z-fo...
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Article
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia
Qing Lan and colleagues report the results of a genome-wide association study of lung cancer in never-smoking women from Asia. They identify three new susceptibility loci and confirm three other previously rep...
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Article
Open AccessExpression profile and prognostic role of sex hormone receptors in gastric cancer
Increasing interest has been devoted to the expression and possible role of sex hormone receptors in gastric cancer, but most of these findings are controversial. In the present study, the expression profile o...
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Article
WIN55,212-2 protects oligodendrocyte precursor cells in stroke penumbra following permanent focal cerebral ischemia in rats
To explore whether the synthetic cannabinoid receptor agonist WIN55,212-2 could protect oligodendrocyte precursor cells (OPCs) in stroke penumbra, thereby providing neuroprotection following permanent focal ce...
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Article
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus–related hepatocellular carcinoma
Long Yu and colleagues report a genome-wide association study for hepatitis B virus–related hepatocellular carcinoma (HBV-HCC). They report that genetic variants in STAT4 and HLA-DQ genes confer risk of HBV-HCC.
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Article
The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA
The intracellular sensor DDX41 is important for generating innate responses to DNA viruses. Liu et al. demonstrate that the ubiquitin ligase TRIM21 degrades and thereby regulates DDX41-dependent responses.
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Article
HBV infection increases the risk of pancreatic cancer: a meta-analysis
Hepatitis B virus (HBV) infection is reported to be associated with an increased risk of pancreatic cancer (PaC), but it remains controversial whether this is a causal relationship. In addition, it is unclear ...
