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Article
Highly Compressible and Lightweight Al2O3/PCNF@ANF Aerogels for Effective Oil Adsorption and Separation
Due to the lightweight feature, superior hydrophobic and oleophilic property, as well as remarkable adsorption capability, carbon-based aerogels have become appealing adsorbents for removing leaking oils and t...
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Article
Vascular smooth muscle-specific LRRC8A knockout ameliorates angiotensin II-induced cerebrovascular remodeling by inhibiting the WNK1/FOXO3a/MMP signaling pathway
Hypertensive cerebrovascular remodeling involves the enlargement of vascular smooth muscle cells (VSMCs), which activates volume-regulated Cl− channels (VRCCs). The leucine-rich repeat-containing family 8 A (LRRC...
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Article
Open AccessThe causal relationship between sleep disturbances and the risk of frailty: a two-sample Mendelian randomization study
Adequate sleep is closely related to people's health. However, with increasing age, the quality of sleep worsens. At the same time, among elderly individuals, frailty is also a disturbing factor, which makes e...
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Article
Open AccessGenetic drivers of heterogeneity in type 2 diabetes pathophysiology
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic c...
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Article
Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n
Nondestructive and noninvasive neutron assays are essential applications of neutron techniques. Neutron resonance transmission analysis (NRTA) is a powerful nondestructive method for investigating the elementa...
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Article
Open AccessChanges in frailty and depressive symptoms among middle-aged and older Chinese people: a nationwide cohort study
The older people bears a severe burden of disease due to frailty and depressive symptoms, however, the results of association between the two in the older Chinese people have been conflicting. Therefore, this ...
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Article
Open AccessEnergy dependence of coherent photonuclear production of J/ψ mesons in ultra-peripheral Pb-Pb collisions at \( \sqrt{{\textrm{s}}_{\textrm{NN}}} \) = 5.02 TeV
The cross section for coherent photonuclear production of J/ψ is presented as a function of the electromagnetic dissociation (EMD) of Pb. The measurement is performed with the ALICE detector in ultra-peripheral P...
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Article
Open AccessChemoresistant fibroblasts dictate neoadjuvant chemotherapeutic response of head and neck cancer via TGFα-EGFR paracrine signaling
Conventional chemotherapy targets malignant cells without evaluating counter protection from the tumor microenvironment that often causes treatment failure. Herein, we establish chemoresistant fibroblasts (rCA...
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Article
Open AccessSuppressive stroma-immune prognostic signature impedes immunotherapy in ovarian cancer and can be reversed by PDGFRB inhibitors
As the most lethal gynecologic cancer, ovarian cancer (OV) holds the potential of being immunotherapy-responsive. However, only modest therapeutic effects have been achieved by immunotherapies such as immune c...
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Article
Measurement of the 232Th(n,f) cross section in the 1–200 MeV range at the CSNS Back-n
The 232Th(n,f) cross section is very important in basic nuclear physics and applications based on the Th/U fuel cycle. Using the time-of-flight method and a multi-cell fast-fission ionization chamber, a novel mea...
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Article
Open AccessAlpha-lipoic acid attenuates heat stress-induced apoptosis via upregulating the heat shock response in porcine parthenotes
Heat stress (HS) is a long-standing hurdle that animals face in the living environment. Alpha-lipoic acid (ALA) is a strong antioxidant synthesized by plants and animals. The present study evaluated the mechan...
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Article
Centrosymmetric to noncentrosymmetric structural transformation in a superconducting high-entropy alloy due to carbon addition
The tetragonal σ phase is one of the most frequently occurring phases in transition metal alloys. However, the effect of carbon addition in σ type high-entropy alloys (HEAs) has not been studied to date. Here we ...
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Article
Open AccessMetavirome of 31 tick species provides a compendium of 1,801 RNA virus genomes
The increasing prevalence and expanding distribution of tick-borne viruses globally have raised health concerns, but the full repertoire of the tick virome has not been assessed. We sequenced the meta-transcri...
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Article
Open AccessMETTL4-mediated nuclear N6-deoxyadenosine methylation promotes metastasis through activating multiple metastasis-inducing targets
DNA N6-methyldeoxyadenosine (6mA) is rarely present in mammalian cells and its nuclear role remains elusive.
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Article
Fungal diversity notes 1512–1610: taxonomic and phylogenetic contributions on genera and species of fungal taxa
This article is the 14th in the Fungal Diversity Notes series, wherein we report 98 taxa distributed in two phyla, seven classes, 26 orders and 50 families which are described and illustrated. Taxa in this stu...
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Article
Rose Bengal inhibits β-amyloid oligomers-induced tau hyperphosphorylation via acting on Akt and CDK5 kinases
Tau hyperphosphorylation and aggregation is considered as a main pathological mechanism underlying Alzheimer’s disease (AD). Rose Bengal (RB) is a synthetic dye used for disease diagnosis, which was reported ...
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Article
Open AccessRegain flood adaptation in rice through a 14-3-3 protein OsGF14h
Contemporary climatic stress seriously affects rice production. Unfortunately, long-term domestication and improvement modified the phytohormones network to achieve the production needs of cultivated rice, thu...
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Article
Open AccessmiR-29b-3p suppresses the malignant biological behaviors of AML cells via inhibiting NF-κB and JAK/STAT signaling pathways by targeting HuR
HuR/ELAVL1 (embryonic lethal abnormal vision 1) was a downstream target of miR-29b in some cancer cells. HuR protein exerts important prognostic effects of involving in the pathogenesis and development of acut...
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Article
Luminosity distribution of fast radio bursts from CHIME/FRB Catalog 1 by means of the updated Macquart relation
Fast radio bursts (FRBs) are extremely strong radio flares lasting several micro- to milliseconds and come from unidentified objects at cosmological distances, most of which are only seen once. Based on recent...
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Article
Open AccessEnhancement of superconductivity on the verge of a structural instability in isovalently doped β-ThRh1−xIrxGe
β-ThRhGe, the high-temperature polymorph of ThRhGe, is isostructural to the well-known ferromagnetic superconductor URhGe. However, contrary to URhGe, β-ThRhGe is nonmagnetic and undergoes an incomplete structura...
