171 Result(s)
within
**ang Han
Life Sciences
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Article
Open AccessGenome-wide analysis of the family 10 plant pathogenesis-related proteins in Pyrus bretschneideri and functional analysis of PbrMLP for Colletotrichum fructicola resistance
Pathogenesis-related (PR) genes are key regulators of plant adaptation responses to biotic and abiotic stresses. Family 10 PRs (PR10s, also known as major latex proteins) are usually induced by pathogens and envi...
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Open AccessMetagenomic and metabolomic analysis showing the adverse risk–benefit trade-off of the ketogenic diet
Ketogenic diets are increasingly popular for addressing obesity, but their impacts on the gut microbiota and metabolome remain unclear. This paper aimed to investigate how a ketogenic diet affects intestinal m...
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Open AccessA chromosome-level genome assembly and annotation of the medicinal plant Lepidium apetalum
As a traditional Chinese medicine, Lepidium apetalum is commonly used for purging the lung, relieving dyspnea, alleviating edema, and has the significant pharmacological effects on cardiovascular disease, hyperli...
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Open AccessGenome-wide characterisation of HD-Zip transcription factors and functional analysis of PbHB24 during stone cell formation in Chinese white pear (Pyrus bretschneideri)
The homodomain-leucine zipper (HD-Zip) is a conserved transcription factor family unique to plants that regulate multiple developmental processes including lignificaion. Stone cell content is a key determinant...
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Correction to: Effects of selenium application with different combinations of secondary elements on ‘Qingcui’ plum leaf nutrition and fruit quality
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Open AccessRetraction Note: Indirubin exerts anticancer effects on human glioma cells by inducing apoptosis and autophagy
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Open AccessTAB182 regulates glycolytic metabolism by controlling LDHA transcription to impact tumor radiosensitivity
Metabolic reprogramming, a hallmark of cancer, is closely associated with tumor development and progression. Changes in glycolysis play a crucial role in conferring radiation resistance to tumor cells. How rad...
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Open AccessAccumulation mechanism of metabolite markers identified by machine learning between Qingyuan and **ushui counties in Polygonatum cyrtonema Hua
Polygonatum cyrtonema Hua is a traditional Chinese medicinal plant acclaimed for its therapeutic potential in diabetes and various chronic diseases. Its rhizomes are the main functional parts rich in secondary me...
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Open AccessChemoproteomics-based profiling reveals potential antimalarial mechanism of Celastrol by disrupting spermidine and protein synthesis
Malaria remains a global health burden, and the emergence and increasing spread of drug resistance to current antimalarials poses a major challenge to malaria control. There is an urgent need to find new drugs...
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Open AccessIntegrated transcriptome and metabolome analysis provides insights into blue light response of Flammulina filiformis
Blue light promotes primordium differentiation and fruiting body formation of mushroom. However, the blue light response mechanism of mushroom remains unclear. In this study, mycelium of Flammulina filiformis was...
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Open AccessUncovering the mechanisms underlying pear leaf apoplast protein-mediated resistance against Colletotrichum fructicola through transcriptome and proteome profiling
Pear anthracnose, caused by the fungus Colletotrichum fructicola, is a devastating disease for the pear industry. The apoplast, an extracellular compartment outside the plasma membrane, plays a crucial role in wa...
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Open AccessSumoylation of SAP130 regulates its interaction with FAF1 as well as its protein stability and transcriptional repressor function
Fas-associated factor 1 (FAF1) is a multidomain protein that interacts with diverse partners to affect numerous cellular processes. Previously, we discovered two Small Ubiquitin-like Modifier (SUMO)-interactin...
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Open AccessLysophosphatidic acid exerts protective effects on HEI-OC1 cells against cytotoxicity of cisplatin by decreasing apoptosis, excessive autophagy, and accumulation of ROS
Lysophosphatidic acid (LPA) is an active phospholipid signaling molecule that binds to six specific G protein-coupled receptors (LPA1-6) on the cell surface and exerts a variety of biological functions, including...
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Open AccessMaleic acid and malonic acid reduced the pathogenicity of Sclerotinia sclerotiorum by inhibiting mycelial growth, sclerotia formation and virulence factors
Sclerotinia sclerotiorum is a necrotrophic plant pathogenic fungus with broad distribution and host range. Bioactive compounds derived from plant extracts have been proven to be effective in controlling S. sclero...
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Open AccessPyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes
Hyperglycemia-induced aberrant glucose metabolism is a causative factor of neurodegeneration and cognitive impairment in diabetes mellitus (DM) patients. The pyruvate dehydrogenase kinase (PDK)–lactic acid axi...
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Open AccessNanopore long-read RNA sequencing reveals functional alternative splicing variants in human vascular smooth muscle cells
Vascular smooth muscle cells (VSMCs) are the major contributor to vascular repair and remodeling, which showed high level of phenotypic plasticity. Abnormalities in VSMC plasticity can lead to multiple cardiov...
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Open AccessStructural divergence and phylogenetic relationships of Ajania (Asteraceae) from plastomes and ETS
Ajania Poljakov, an Asteraceae family member, grows mostly in Asia’s arid and semi-desert areas and is a significant commercial and decorative plant. Nevertheless, the genus’ classification has been disputed, and...
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Open AccessStatistically unbiased prediction enables accurate denoising of voltage imaging data
Here we report SUPPORT (statistically unbiased prediction utilizing spatiotemporal information in imaging data), a self-supervised learning method for removing Poisson–Gaussian noise in voltage imaging data. S...
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Open AccessExploring the association between COVID-19 and male genital cancer risk in European population: evidence from mendelian randomization analysis
Recently accumulated evidence indicates a potential association between COVID-19 and elevated susceptibility to cancer, including male genital cancer. However, the causal nature of this relationship remains un...
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Open AccessApple Valsa canker: insights into pathogenesis and disease control
Apple Valsa canker (AVC) has caused significant losses worldwide, especially in East Asia. Various fungal species from the genus Cytospora/Valsa can infect tree bark and cause tissue rot, and Valsa mali (Vm) is r...
