-
Article
Niche similarity accompanying COI genetic differentiations in asexual and sexual Corbicula lineages within East and Southeast Asia
Asexual eukaryotes tend to occupy broader geographical ranges than their sexually reproducing relatives, with this phenomenon seemingly linked to ecological differentiation among closely related asexual and se...
-
Article
Open AccessA common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma
By incompletely understood mechanisms, type 2 (T2) inflammation present in the airways of severe asthmatics drives the formation of pathologic mucus which leads to airway mucus plugging. Here we investigate th...
-
Article
Open AccessFocal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer
Targeted therapy is effective in many tumor types including lung cancer, the leading cause of cancer mortality. Paradigm defining examples are targeted therapies directed against non-small cell lung cancer (NS...
-
Article
Adult age estimation from the sternum using maximum intensity projection images of CT and data mining in a Chinese population
This study aimed to explore and develop data mining models for adult age estimation based on CT reconstruction images from the sternum. Maximum intensity projection (MIP) images of chest CT were retrospectivel...
-
Article
Open AccessLoss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment
Despite regulating overlap** gene enhancers and pathways, CREBBP and KMT2D mutations recurrently co-occur in germinal center (GC) B cell-derived lymphomas, suggesting potential oncogenic cooperation. Herein, we...
-
Article
Open AccessMap** crossover events of mouse meiotic recombination by restriction fragment ligation-based Refresh-seq
Single-cell whole-genome sequencing methods have undergone great improvements over the past decade. However, allele dropout, which means the inability to detect both alleles simultaneously in an individual dip...
-
Article
A guideline on the molecular ecosystem regulating ferroptosis
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnesse...
-
Article
Musculoskeletal imaging of senescence
Senescent cells play a vital role in the pathogenesis of musculoskeletal (MSK) diseases, such as chronic inflammatory joint disorders, rheumatoid arthritis (RA), and osteoarthritis (OA). Cellular senescence in...
-
Article
Open Accessmini-MED: study protocol for a randomized, multi-intervention, semi-controlled feeding trial of a Mediterranean-amplified vs. habitual Western dietary pattern for the evaluation of food-specific compounds and cardiometabolic health
Diet is among the most influential lifestyle factors impacting chronic disease risk. Nutrimetabolomics, the application of metabolomics to nutrition research, allows for the detection of food-specific compound...
-
Article
Open AccessA compendium of genetic regulatory effects across pig tissues
The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking genetic polymorphisms...
-
Article
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-a...
-
Article
Open AccessA transcriptomic taxonomy of mouse brain-wide spinal projecting neurons
The brain controls nearly all bodily functions via spinal projecting neurons (SPNs) that carry command signals from the brain to the spinal cord. However, a comprehensive molecular characterization of brain-wi...
-
Article
Open AccessSTCF conceptual design report (Volume 1): Physics & detector
The super τ-charm facility (STCF) is an electron–positron collider proposed by the Chinese particle physics community. It is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak lumino...
-
Article
Open AccessSearch for direct production of winos and higgsinos in events with two same-charge leptons or three leptons in pp collision data at \( \sqrt{s} \) = 13 TeV with the ATLAS detector
A search for supersymmetry targeting the direct production of winos and higgsinos is conducted in final states with either two leptons (e or μ) with the same electric charge, or three leptons. The analysis uses 1...
-
Article
Open AccessDeep learning-driven adaptive optics for single-molecule localization microscopy
The inhomogeneous refractive indices of biological tissues blur and distort single-molecule emission patterns generating image artifacts and decreasing the achievable resolution of single-molecule localization...
-
Article
Deep learning enables automatic adult age estimation based on CT reconstruction images of the costal cartilage
Adult age estimation (AAE) is a challenging task. Deep learning (DL) could be a supportive tool. This study aimed to develop DL models for AAE based on CT images and compare their performance to the manual vis...
-
Article
Open AccessMeasurement of the non-prompt D-meson fraction as a function of multiplicity in proton-proton collisions at \( \sqrt{s} \) = 13 TeV
The fractions of non-prompt (i.e. originating from beauty-hadron decays) D0 and D+ mesons with respect to the inclusive yield are measured as a function of the charged-particle multiplicity in proton-proton colli...
-
Article
Open AccessA universal programmable Gaussian boson sampler for drug discovery
Gaussian boson sampling (GBS) has the potential to solve complex graph problems, such as clique finding, which is relevant to drug discovery tasks. However, realizing the full benefits of quantum enhancements ...
-
Article
Open AccessSearch for a light charged Higgs boson in t → H±b decays, with H± → cb, in the lepton+jets final state in proton-proton collisions at \( \sqrt{s} \) = 13 TeV with the ATLAS detector
A search for a charged Higgs boson, H±, produced in top-quark decays, t → H±b, is presented. The search targets H± decays into a bottom and a charm quark, H± → cb. The analysis focuses on a selection enriched in ...
-
Article
Open AccessEvidence for the charge asymmetry in pp → \( t\overline{t} \) production at \( \sqrt{s} \) = 13 TeV with the ATLAS detector
Inclusive and differential measurements of the top–antitop ( t t
