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  1. No Access

    Article

    HSF1 functions as a transcription regulator for Dp71 expression

    Heat shock factor 1 (HSF1) is one of the most important transcriptional molecules in the heat shock process; however, HSF1 can also regulate the expression of other proteins. Dystrophin Dp71 is one of the most...

    ** Tan, Sichuang Tan, Hexin Zheng, Meidong Liu… in Cell Stress and Chaperones (2015)

  2. No Access

    Article

    Oblongifolin C suppresses lysosomal function independently of TFEB nuclear translocation

    Lysosomes are the terminal organelles of the autophagic-endocytic pathway and play a key role in the degradation of autophagic contents. We previously reported that a natural compound oblongifolin C (OC) incre...

    Man Wu, Yuan-zhi Lao, Hong-sheng Tan, Guang Lu, Yi Ren… in Acta Pharmacologica Sinica (2019)

  3. No Access

    Article

    Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-β1 signaling pathways

    Metastasis causes the main lethality in esophageal cancer patient. Garcinol, a natural compound extracted from Gambogic genera, is a histone acetyltransferase (HAT) inhibitor that has shown anticancer activities ...

    **g Wang, Man Wu, Dan Zheng, Hong Zhang, Yue Lv, Li Zhang… in Acta Pharmacologica Sinica (2020)

  4. No Access

    Article

    Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice

    Mitophagy is a selective form of autophagy involving the removal of damaged mitochondria via the autophagy-lysosome pathway. PINK1-Parkin-mediated mitophagy is one of the most important mechanisms in cardiovas...

    Man Wu, Guang Lu, Yuan-zhi Lao, Hong Zhang, Dan Zheng… in Acta Pharmacologica Sinica (2021)

  5. Article

    Open Access

    circST6GALNAC6 suppresses bladder cancer metastasis by sponging miR-200a-3p to modulate the STMN1/EMT axis

    Bladder cancer (BCa) is an aggressive malignancy because of its distant metastasis and high recurrence rate. Circular RNAs (circRNAs) exert critical regulatory functions in cancer progression. However, the exp...

    Shuo Tan, Ye Kang, Hu Li, Hai-Qing He, Long Zheng, Shui-Qing Wu… in Cell Death & Disease (2021)

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