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  1. No Access

    Article

    Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice

    Mitophagy is a selective form of autophagy involving the removal of damaged mitochondria via the autophagy-lysosome pathway. PINK1-Parkin-mediated mitophagy is one of the most important mechanisms in cardiovas...

    Man Wu, Guang Lu, Yuan-zhi Lao, Hong Zhang, Dan Zheng… in Acta Pharmacologica Sinica (2021)

  2. No Access

    Article

    Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-β1 signaling pathways

    Metastasis causes the main lethality in esophageal cancer patient. Garcinol, a natural compound extracted from Gambogic genera, is a histone acetyltransferase (HAT) inhibitor that has shown anticancer activities ...

    **g Wang, Man Wu, Dan Zheng, Hong Zhang, Yue Lv, Li Zhang… in Acta Pharmacologica Sinica (2020)

  3. No Access

    Article

    Oblongifolin C suppresses lysosomal function independently of TFEB nuclear translocation

    Lysosomes are the terminal organelles of the autophagic-endocytic pathway and play a key role in the degradation of autophagic contents. We previously reported that a natural compound oblongifolin C (OC) incre...

    Man Wu, Yuan-zhi Lao, Hong-sheng Tan, Guang Lu, Yi Ren… in Acta Pharmacologica Sinica (2019)

  4. No Access

    Article

    HSF1 functions as a transcription regulator for Dp71 expression

    Heat shock factor 1 (HSF1) is one of the most important transcriptional molecules in the heat shock process; however, HSF1 can also regulate the expression of other proteins. Dystrophin Dp71 is one of the most...

    ** Tan, Sichuang Tan, Hexin Zheng, Meidong Liu… in Cell Stress and Chaperones (2015)