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Article
Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor
Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, ...
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Article
Open AccessSerum selenium and fasting blood glucose: a cross-sectional study in women of different menopause status
This cross-sectional study aims to explore whether there exists an interaction between selenium and menopause concerning type 2 diabetes (T2D) prevalence and its related indicators such as fasting blood glucos...
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Article
Application of deep learning methods combined with physical background in wide field of view imaging atmospheric Cherenkov telescopes
The High Altitude Detection of Astronomical Radiation (HADAR) experiment, which was constructed in Tibet, China, combines the wide-angle advantages of traditional EAS array detectors with the high-sensitivity ...
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Article
A long non-coding RNA functions as a competitive endogenous RNA to modulate TaNAC018 by acting as a decoy for tae-miR6206
Increasing evidence indicates a strong correlation between the deposition of cuticular waxes and drought tolerance. However, the precise regulatory mechanism remains elusive. Here, we conducted a comprehensive...
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Article
The identification method for rock strength and joint while drilling based on cutting energy density
Rock strength and joint parameters are the basic parameters reflecting engineering rock quality. The traditional rock strength testing method requires taking cores from the surrounding rock on site and transpo...
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Article
Creep property and microstructural evolution of DD11 alloy under high temperature and low stress
In this paper, the interrupted and ruptured creep tests were carried out in a novel second generation single crystal superalloy named DD11 at 1100 °C/130 MPa. The alloy exhibited typical creep curve including ...
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Article
Open AccessDefining the biogeographical map and potential bacterial translocation of microbiome in human ‘surface organs’
The microbiome in a specific human organ has been well-studied, but few reports have investigated the multi-organ microbiome as a whole. Here, we aim to analyse the intra-individual inter-organ and intra-organ...
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Article
Open AccessAdvances in nuclear detection and readout techniques
“A Craftsman Must Sharpen His Tools to Do His Job,” said Confucius. Nuclear detection and readout techniques are the foundation of particle physics, nuclear physics, and particle astrophysics to reveal the nat...
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Article
Shear-induced rockburst of double-tunnel rocks subjected to shear loading: A comparative analysis
Understanding triggering mechanism of shear-induced rockburst is of great significance for design, construction and operation in underground engineering. To reveal triggering rockburst mechanism in double-tunn...
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Article
Survey of the Prosthogonimus spp. metacercariae infection in the second intermediate host dragonfly in Heilongjiang Province, China
Prosthogonimiasis poses a threat to the reproductive system of poultry and wild birds, which are the definitive hosts of the parasite causing this disease. However, the parasite infection of the second interme...
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Article
Measurement of Br(n,γ) cross sections up to stellar s-process temperatures at the CSNS Back-n
The neutron capture cross sections ( \({n,\gamma }\) n , ...
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Article
Microbe-induced gene silencing boosts crop protection against soil-borne fungal pathogens
Small RNA (sRNA)-mediated trans-kingdom RNA interference (RNAi) between host and pathogen has been demonstrated and utilized. However, interspecies RNAi in rhizospheric microorganisms remains elusive. In this ...
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Article
Open AccessMALAT1/ mir-1-3p mediated BRF2 expression promotes HCC progression via inhibiting the LKB1/AMPK signaling pathway
The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been reported to play a vital role in the occurrence and development of various tumors. However, the underlying mecha...
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Article
A unified reliability evaluation framework for aircraft turbine rotor considering multi-site failure correlation
Multiple dangerous sites often coexist in complex structures like aircraft turbine rotors, and its failure-correlated reliability evaluation usually occurs the thorny problems of high-efficacy computing and co...
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Article
Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression
Cancer stem cells (CSCs) are a minority population of cancer cells with stemness and multiple differentiation potentials, leading to cancer progression and therapeutic resistance. However, the concrete mechani...
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Article
Biomarkers of aging
Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although ...
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Article
Hepatitis B virus reactivation in patients undergoing immune checkpoint inhibition: systematic review with meta-analysis
Immune checkpoint inhibitors (ICIs) have been explored as first-line treatment in various types of previously untreatable malignancies, while limited evidence is available on the management of hepatitis B viru...
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Article
Altered gut microbiota composition in children and their caregivers infected with the SARS-CoV-2 Omicron variant
Gut microbiota alterations have been implicated in the pathogenesis of coronavirus disease 2019 (COVID-19). This study aimed to explore gut microbiota changes in a prospective cohort of COVID-19 children and t...
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Article
Efficacy and security of tumor vaccines for hepatocellular carcinoma: a systemic review and meta-analysis of the last 2 decades
Tumor vaccines for hepatocellular carcinoma (HCC) is an area of intense interest. Tremendous clinical trials have been conducted globally, but the efficacy and security of tumor vaccines are elusive. The aim o...
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Article
Open AccessMap** the long-term delayed recall-based cortex-hippocampus network constrained by the structural and functional connectome: a case-control multimodal MRI study
Connectome map** may reveal new treatment targets for patients with neurological and psychiatric diseases. However, the long-term delayed recall based-network with structural and functional connectome is sti...
