467 Result(s)

Article

BOLERO-5: a phase II study of everolimus and exemestane combination in Chinese post-menopausal women with ER + /HER2- advanced breast cancer

The global BOLERO-2 trial established the efficacy and safety of combination everolimus (EVE) and exemestane (EXE) in the treatment of estrogen receptor positive (ER +), HER2-, advanced breast cancer (ABC). BO...

Zhi-Ming Shao, Li Cai, Shusen Wang, **chun Hu, Kunwei Shen, Haibo Wang… in Discover Oncology (2024)

Article

Remodeling of anti-tumor immunity with antibodies targeting a p53 mutant

p53, the most frequently mutated gene in cancer, lacks effective targeted drugs.

Dafei Chai, Junhao Wang, Chunmei Fan, **g-Ming Lim… in Journal of Hematology & Oncology (2024)

Article

A miRNA-disease association prediction model based on tree-path global feature extraction and fully connected artificial neural network with multi-head self-attention mechanism

MicroRNAs (miRNAs) emerge in various organisms, ranging from viruses to humans, and play crucial regulatory roles within cells, participating in a variety of biological processes. In numerous prediction method...

Hou Biyu, Li Mengshan, Hou Yuxin, Zeng Ming, Wang Nan, Guan Lixin in BMC Cancer (2024)

Article

USP47 deficiency in mice modulates tumor infiltrating immune cells and enhances antitumor immune responses in prostate cancer

This study investigates the role of USP47, a deubiquitinating enzyme, in the tumor microenvironment and its impact on antitumor immune responses. Analysis of TCGA database revealed distinct expression patterns...

Qian-Lan Wang, Shun-Yuan Lu, Dan-Dan Xu, **-**a Ma… in Cancer Immunology, Immunotherapy (2024)

Article

Clinical significance and prospective mechanism of increased CDKN2A expression in small cell lung cancer

Although it has been shown that cyclin dependent kinase inhibitor 2A (CDKN2A) plays a significant role in a number of malignancies, its clinicopathological value and function in small cell lung cancer (SCLC) i...

Dong-Ming Li, Guo-Sheng Li, Jian-Di Li, Feng Chen… in Clinical and Translational Oncology (2024)

Article

ESM1 enhances fatty acid synthesis and vascular mimicry in ovarian cancer by utilizing the PKM2-dependent warburg effect within the hypoxic tumor microenvironment

The hypoxic tumor microenvironment is a key factor that promotes metabolic reprogramming and vascular mimicry (VM) in ovarian cancer (OC) patients. ESM1, a secreted protein, plays an important role in promotin...

Juan Zhang, Fan Ouyang, Anbo Gao, Tian Zeng, Ming Li, Hui Li… in Molecular Cancer (2024)

Article

Correction: Predictive Value of a New Muscle Parameter in Patients with Resectable Gastric Cancer: A Pooled Analysis of Three Prospective Trials

Qing Zhong MD, Jiao-Bao Huang MD, Jun Lu MD, PhD… in Annals of Surgical Oncology (2024)

Article

Predictive Value of a New Muscle Parameter in Patients with Resectable Gastric Cancer: A Pooled Analysis of Three Prospective Trials

Sarcopenia is closely associated with gastric cancer (GC) prognosis. However, its exact definition remains controversial.

Qing Zhong MD, Jiao-Bao Huang MD, Jun Lu MD, PhD… in Annals of Surgical Oncology (2024)

Article

Nanoparticle Polymeric Micellar Paclitaxel Versus Paclitaxel for Patients with Advanced Gastric Cancer

Nanoparticle polymeric micellar paclitaxel (NPMP) is a novel Cremophor EL (CrEL)-free nanoparticle micellar formulation of paclitaxel. This study evaluated the efficacy and toxicity of NPMP in the treatment of...

Fei-Yu Wang, **ang-Ming Huang, Yu-Qing Cao, Jie Cao… in Journal of Gastrointestinal Cancer (2024)

Article

Identification of immune-associated biomarker for predicting lung adenocarcinoma: bioinformatics analysis and experiment verification of PTK6

Abnormal expression of protein tyrosine kinase 6 (PTK6) has been proven to be involved in the development of gynecological tumors. However, its immune-related carcinogenic mechanism in other tumors remains unc...

Ren-Hui **ong, Shuo-Qi Yang, Ji-Wei Li, Xun-kai Shen, Lu-Ming **… in Discover Oncology (2024)

Article

A radiomics signature derived from CT imaging to predict MSI status and immunotherapy outcomes in gastric cancer: a multi-cohort study

Accurate microsatellite instability (MSI) testing is essential for identifying gastric cancer (GC) patients eligible for immunotherapy. We aimed to develop and validate a CT-based radiomics signature to predic...

Peng-chao Zhan, Shuo Yang, **ng Liu, Yu-yuan Zhang, Rui Wang, Jia-xing Wang… in BMC Cancer (2024)

Article

Extracellular matrix protein 1 (ECM1) is a potential biomarker in B cell acute lymphoblastic leukemia

B cell acute lymphoblastic leukemia (ALL) is characterized by the highly heterogeneity of pathogenic genetic background, and there are still approximately 30–40% of patients without clear molecular markers. To...

Li-**n Wu, Ming-Yue Zhao, Nan Yan, Ya-Lan Zhou… in Clinical and Experimental Medicine (2024)

Article

Efficacy and safety of generic pomalidomide plus low-dose dexamethasone in relapsed or refractory multiple myeloma: a multicenter, open-label, single-arm trial

This multicenter, open-label, single-arm trial (ClinicalTrials.gov, NCT05236621) was conducted to confirm the efficacy and safety of generic pomalidomide plus dexamethasone in Chinese patients with relapsed or...

Huixing Zhou, Yafei Wang, Jiao Chen, Aili He, Jie **, Quanyi Lu… in Annals of Hematology (2024)

Article

Trajectories of neutrophil-to-lymphocyte ratios during neoadjuvant chemotherapy correlate with short- and long-term outcomes in gastric cancer: a group-based trajectory analysis

Systemic inflammatory factors can predict the survival prognosis of gastric cancer (GC) patients after neoadjuvant chemotherapy (NACT). However, whether longitudinal changes in systemic inflammatory factors ar...

Hua-Long Zheng, Fu-Hai Wang, Ling-Kang Zhang, ** Li, Chao-Hui Zheng… in BMC Cancer (2024)

Article

High expression of PAFAH1B3 results in poor prognosis in lung adenocarcinoma patients and is associated with tumor cell pyroptosis genes

Lung adenocarcinoma (LUAD) is a common cancer with a poor prognosis. Platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29 kDa (PAFAH1B3) plays an important role in the development of many type...

Bowen Hu, Lingyu Du, Guangda Yuan, Yong Yang, Ming Li, Jie Tan in Clinical Cancer Bulletin (2024)

Article

Contrast-enhanced CT radiomics features to preoperatively identify differences between tumor and proximal tumor-adjacent and tumor-distant tissues of resectable esophageal squamous cell carcinoma

Esophagectomy is the main treatment for esophageal squamous cell carcinoma (ESCC), and patients with histopathologically negative margins still have a relatively higher recurrence rate. Contrast-enhanced CT (C...

Dan Gao, Bang-guo Tan, **ao-qian Chen, Chuanqinyuan Zhou, **g Ou… in Cancer Imaging (2024)

Article

ER-positive and BRCA2-mutated breast cancer: a literature review

BRCA2-mutated carriers have a high lifetime risk of breast cancer (BC), an early age of onset, and an increased risk of other cancers (including ovarian, pancreatic, and prostate cancer). Almost 70–80% of BRCA2-m...

Pu-Chun Li, Yi-Fan Zhu, Wen-Ming Cao, Bei Li in European Journal of Medical Research (2024)

Article

Icariin improves cardiac function and remodeling via the TGF-β1/Smad signaling pathway in rats following myocardial infarction

Postinfarction cardiac remodeling presents a compensatory mechanism aimed at mitigating congestive heart failure. It is distinguished by progressive dilatation and hypertrophy of the ventricular chambers, fibr...

Ji Jia, **ng-an Zhao, Si-ming Tao, Jun-wen Wang… in European Journal of Medical Research (2023)

Article

Prognostic implications of alpha-fetoprotein and C-reactive protein elevation in hepatocellular carcinoma following resection (PACE): a large cohort study of 2770 patients

Routine clinical staging for hepatocellular carcinoma (HCC) incorporates liver function, general health, and tumor morphology. Further refinement of prognostic assessments and treatment decisions may benefit f...

Kong-Ying Lin, Qing-**g Chen, Shi-Chuan Tang, Zhi-Wen Lin, Jian-** Zhang… in BMC Cancer (2023)

Article

Correction: UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expression of PDK1 through PI3K/AKT signaling

Jian-**an Lin, **n-Sheng **e… in Journal of Experimental & Clinical Cancer … (2023)