974 Result(s)
within
**-ming Li
Biomedicine, general
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Article
Efficient Transformation of Tobacco by Ultrasonication
We report a simple, direct gene transfer technique based on sonication. Transient expression of a β–glucoronidase (GUS) gene was detected in 86 percent of treated leaf segments of Nicotiana tabacum, and the area ...
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Article
HIV 10 years later-where do we stand now?
A wide variety of up-to-date results and knowledge were presented at the 10th International AIDS Meeting, Yokohama. Epidemiologically, most interest was focused on the discovery of a new HIV subtype O, which c...
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Article
A method for isolating and culturing vascular smooth muscle cells from porcine cerebral arteries
Cerebral blood vessels have unique properties when compared to most peripheral vascular beds. One such property is that large cerebral vessels are involved in the regulation of cerebral vascular resistance. St...
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Contributory presentations/posters
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Article
Visual input induces long-term potentiation of develo** retinotectal synapses
Early visual experience is essential in the refinement of develo** neural connections. In vivo whole-cell recording from the tectum of Xenopus tadpoles showed that repetitive dimming-light stimulation applied t...
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Article
Genetic basis of total colourblindness among the **elapese islanders
Complete achromatopsia is a rare, autosomal recessive disorder characterized by photophobia, low visual acuity, nystagmus and a total inability to distinguish colours. In this disease, cone photoreceptors, the...
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Article
Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine
The breaking of immune tolerance against autologous angiogenic endothelial cells should be a useful approach for cancer therapy. Here we show that immunotherapy of tumors using fixed xenogeneic whole endotheli...
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Article
Reply To "Do 'smart' mice feel more pain, or are they just better learners?"
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Article
Electrical activity and development of neural circuits
A distinct feature of the nervous system is the intricate network of synaptic connections among neurons of diverse phenotypes. Although initial connections are formed largely through molecular mechanisms that ...
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Article
A protein kinase A–dependent molecular switch in synapsins regulates neurite outgrowth
Cyclic AMP (cAMP) promotes neurite outgrowth in a variety of neuronal cell lines through the activation of protein kinase A (PKA). We show here, using both Xenopus laevis embryonic neuronal culture and intact X. ...
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Article
Pyronin Y as a Fluorescent Stain for Paraffin Sections
Pyronin Y has long been used, in combination with other dyes such as Methyl Green, as a differential stain for nucleic acids in paraffin tissue sections. It also forms fluorescent complexes with double-strande...
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Article
Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4
Nasopharyngeal carcinoma (NPC) occurs with high frequency in Asian populations, especially among people of Cantonese ancestry. In areas with high incidence, NPC clusters in families, which suggests that both g...
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Article
Nerve growth cone guidance mediated by G protein–coupled receptors
Growing axons navigate by responding to chemical guidance cues. Here we report that growth cones of rat cerebellar axons in culture turned away from a gradient of SDF-1, a chemokine that attracts migrating leu...
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Inhibition of ras-mediated cell proliferation by benzyloxybenzaldehyde
Excessive proliferation of vascular smooth muscle cells (VSMC) in the intima is an important etiologic factor in vascular proliferative disorders such as atherosclerosis and restenosis after balloon angioplast...
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Article
Regression of bone metastases following adoptive transfer of anti-CD3-activated and IL-2-expanded tumor vaccine draining lymph node cells
As many as 80% of patients with breast, prostate, or lung cancer develop bone metastases during the course of their illness. However, thus far, no attempts have been made to explore the potential value of adop...
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Article
Interaction of Hydrogen Peroxide with Ribulose-1,5-bisphosphate Carboxylase/Oxygenase from Rice
The properties of rice-derived ribulose-1,5-bisphosphate carboxylase/oxygenase (rubisco) in different concentrations of hydrogen peroxide (H2O2) solutions have been studied. The results indicate that at low H2O2 ...
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Article
Cancer-specific activation of the survivin promoter and its potential use in gene therapy
Survivin is expressed in many cancers but not in normal adult tissues and is transcriptionally regulated. To test the feasibility of using the survivin promoter to induce cancer-specific transgene expression i...
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Article
Focal adhesion kinase in netrin-1 signaling
Netrins are a family of secreted molecules that are important for axonal outgrowth and guidance in the develo** nervous system. However, the signaling mechanisms that lie immediately downstream of netrin rec...
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Article
Protective effects of cariporide on endothelial dysfunction induced by high glucose
To explore the effects of cariporide, a selective sodium-hydrogen antiporter inhibitor, on endothelial dysfunction induced by high glucose.
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Article
Tanshinone IIA isolated from Salvia miltiorrhiza elicits the cell death of human endothelial cells
Tanshinone IIA, a major component extracted from the traditional herbal medicine, Salvia miltiorrhiza Bunge, is known to exhibit potent cytotoxicity against various human carcinoma cells in vitro. However, the me...
