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  1. No Access

    Article

    Plasma Ionomic Profile and Interaction Patterns in Coronary Artery Disease Patients

    Humans are exposed to various chemical elements that have been associated with the development and progression of diseases such as coronary artery disease (CAD). Unlike previous research, we employed a multi-e...

    Qing-Qing Zhao, **an-Long Shu, Zhen Yuan, Qian Gao… in Biological Trace Element Research (2024)

  2. No Access

    Article

    Inflammation in Metal-Induced Neurological Disorders and Neurodegenerative Diseases

    Essential metals play critical roles in maintaining human health as they participate in various physiological activities. Nonetheless, both excessive accumulation and deficiency of these metals may result in n...

    Ruokun Wei, Peiqi Wei, Haiyan Yuan, **ang Yi… in Biological Trace Element Research (2024)

  3. No Access

    Article

    Isolation of tumor stem-like cells from primary laryngeal squamous cell carcinoma cells (FD-LS-6)

    The development of efficient treatments for laryngeal squamous cell carcinoma (LSCC) is hindered by the lack of applicable tumor cell lines and animal models of the disease, especially those related to cancer ...

    Duo Zhang, Di Tang, Pen-tao Liu, Lei Tao, Li-ming Lu in Human Cell (2024)

  4. No Access

    Article

    Signal Transduction Associated with Mn-induced Neurological Dysfunction

    Manganese (Mn) is a heavy metal that occurs widely in nature and has a vital physiological role in growth and development. However, excessive exposure to Mn can cause neurological damage, especially cognitive ...

    **ao-wei Zheng, Yuan-yuan Fang, Jun-jie Lin… in Biological Trace Element Research (2023)

  5. No Access

    Article

    Zinc supplementation ameliorates sorafenib-induced cognitive impairment through ROS/JNK signaling pathway

    Sorafenib, a multiple kinase inhibitor, is widely used in cancer patients. Recently, clinical studies highlighted the relationship between cognitive deficits and sorafenib exposure. Zinc abundant in the body h...

    Can-Can Zhou, Yu-Qiong He, Yu-Shuang Qiu, Chen-Xu Ni… in Biological Trace Element Research (2023)

  6. No Access

    Article

    Lead Exposure in Developmental Ages Promotes Aβ Accumulation by Disturbing Aβ Transportation in Blood-Cerebrospinal Fluid Barrier/Blood–Brain Barriers and Impairing Aβ Clearance in the Liver

    Environmental lead exposure is closely related to the progression of Alzheimer’s disease (AD). Our previous study has shown that exposure to lead could result in the cholesterol unbalance and increase amyloid-...

    Can-Can Zhou, Xu-Jie Wang, Zi-Chen Li, Wen-Jie Lu… in Biological Trace Element Research (2022)

  7. Article

    Open Access

    RIG-I acts as a tumor suppressor in melanoma via regulating the activation of the MKK/p38MAPK signaling pathway

    Studies have indicated that RIG-I may act as a tumor suppressor and participate in the tumorigenesis of some malignant diseases. However, RIG-I induces distinct cellular responses via different downstream sign...

    Rui Guo, Shun-Yuan Lu, **-**a Ma, Qian-Lan Wang, Lu Zhang, Ling-Yun Tang… in Human Cell (2022)

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  8. No Access

    Article

    Therapeutic Effects of Sodium Para-Aminosalicylic Acid on Cognitive Deficits and Activated ERK1/2-p90RSK/NF-κB Inflammatory Pathway in Pb-Exposed Rats

    Lead (Pb) is a toxic heavy metal and environmental pollutant that adversely affects the nervous system. However, effective therapeutic drugs for Pb-induced neurotoxicity have yet to be developed. In the presen...

    Li-li Lu, Yu-wen Zhang, Zhao-cong Li, Yuan-yuan Fang… in Biological Trace Element Research (2022)

  9. No Access

    Article

    Astragalus Polysaccharide Protects Against Cadmium-Induced Autophagy Injury Through Reactive Oxygen Species (ROS) Pathway in Chicken Embryo Fibroblast

    Cadmium (Cd) is a harmful heavy metal pollutant, which can cause oxidative stress in the body and induce cell damage. Reactive oxygen species (ROS) is a general term for substances that contain oxygen and are ...

    Xudong Shen, Zequn Tang, Yu Bai, Meishuo Wan, Miao Yu… in Biological Trace Element Research (2022)

  10. No Access

    Article

    The optimal number of embryo cells for effective pregnancy and decrease of multiple pregnancy rate in frozen-thawed embryo transfer

    To investigate the effect of the number of embryo cells on the clinical outcome of frozen-thawed embryo transfer and explore the optimal policy for decreases of multiple pregnancy rate, patients who experience...

    Xu-Li Zhu, Zhi-Ming Zhao, Yuan-Jie Du, Liang Zhou, Yue Wang, Qing-Yun Sun… in Human Cell (2021)

  11. No Access

    Article

    Targeted deletion of HAI-1 increases prostasin proteolysis but decreases matriptase proteolysis in human keratinocytes

    Epidermal differentiation and barrier function require well-controlled matriptase and prostasin proteolysis, in which the Kunitz-type serine protease inhibitor HAI-1 represents the primary enzymatic inhibitor ...

    Dajun D. Lu, Yayun Gu, Sheng-Wen A. Li, Robert J. Barndt, Shih-Ming Huang… in Human Cell (2021)

  12. No Access

    Article

    Sodium Para-aminosalicylic Acid Reverses Changes of Glutamate Turnover in Manganese-Exposed Rats

    Sodium para-aminosalicylic acid (PAS-Na) has been used to treat patients with manganism, a neurological disease caused by manganese (Mn) toxicity, although the exact molecular mechanisms are yet unclear. The p...

    Zhao-Cong Li, Fang Wang, Shao-Jun Li, Lin Zhao… in Biological Trace Element Research (2020)

  13. No Access

    Article

    MicroRNA-153-3p enhances the sensitivity of chronic myeloid leukemia cells to imatinib by inhibiting B-cell lymphoma-2-mediated autophagy

    Chronic myeloid leukemia (CML) is a hematopoietic stem cell disease caused by abnormal DNA replication of bone marrow stem cells and chemotherapy resistance is a major obstacle to the effective treatment of pa...

    Yu-Ling Li, Jia-Ming Tang, **ao-Yun Chen, Bing Luo, Guo-Hua Liang, Qian Qu… in Human Cell (2020)

  14. No Access

    Article

    Effect of Dietary Selenium Supplementation on Growth and Reproduction of Silkworm Bombyx mori L.

    The effects of selenium (Se) on the growth and reproduction of the Lepidoptera insect, the silkworm, Bombyx mori L were investigated. Initially, the silkworms were divided into eight groups (150 larvae/group) on ...

    Li Jiang, Li-Li Peng, Yu-Yao Cao, Kiran Thakur, Fei Hu… in Biological Trace Element Research (2020)

  15. No Access

    Article

    Comparative Serum Proteomic Analysis of the Effects of Sodium Selenate on a Mouse Model of Alzheimer’s Disease

    Selenium (Se), as a nutritionally essential trace element, has been shown to decrease with age and is closely related to Alzheimer’s disease (AD). To probe the effects of Se on AD pathology, two-dimensional fl...

    ** Chen, Li-**ang Wang, **ao-**g Sui, Shui-Ming Li… in Biological Trace Element Research (2019)

  16. No Access

    Article

    Effects of Fungal Polysaccharide on Oxidative Damage and TLR4 Pathway to the Central Immune Organs in Cadmium Intoxication in Chickens

    Cadmium (Cd) can cause animal organism damage, but there have been few studies on the damage of cadmium to the immune organs of birds. Most fungal polysaccharide has antioxidant and immunomodulatory effects. T...

    Ruyue Li, Linan Zhang, Zequn Tang, Tianqi Li… in Biological Trace Element Research (2019)

  17. No Access

    Article

    Sulforaphane inhibits the activation of hepatic stellate cell by miRNA-423-5p targeting suppressor of fused

    Liver fibrosis, a common pathological process in chronic liver diseases, is characterized by excessive accumulation of extracellular matrix proteins and considered as a wound healing response to chronic liver ...

    Ming-Hui Feng, Jian-Wei Li, Hai-Tao Sun, Song-Qi He, Jie Pang in Human Cell (2019)

  18. No Access

    Article

    Protective Effect of Ganoderma Triterpenoids on Cadmium-Induced Testicular Toxicity in Chickens

    Studies have shown that cadmium can cause chicken testicular damage, but a protective effect of Ganoderma triterpenoids on cadmium-induced testicular damage in chickens has not yet been reported. The present s...

    Hongmei Wang, Ruili Zhang, Yangyang Song, Tianqi Li… in Biological Trace Element Research (2019)

  19. No Access

    Article

    Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks

    The nuclear-related factor 2 (Nrf2) pathway is the most important mechanism in antioxidant capacity, which regulates the cell’s redox homeostasis. In addition, Nrf2 pathway also can inhibit cell apoptosis. The...

    Haseeb Khaliq, Wang **g, **ao Ke, Yang Ke-Li… in Biological Trace Element Research (2018)

  20. No Access

    Article

    Effects of Boron Supplementation on Expression of Hsp70 in the Spleen of African Ostrich

    Increased synthesis of heat shock protein 70 (Hsp70) occurs in prokaryotes and eukaryotes in response to physiological, environmental, and chemical exposures, thus allowing the cell survival from fatal conditi...

    Khaliq Haseeb, **g Wang, Ke **ao, Ke-li Yang… in Biological Trace Element Research (2018)

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