187 Result(s)

Article

Preparation, characterization, and biological activity of the inclusion complex of dihydroquercetin and β-Cyclodextrin

Dihydroquercetin (DHQ) is a natural occurring dihydroflavonol that has strong antioxidant and antibacterial activities. However, its application is limited due to its poor solubility. This study aims to improv...

Ya** Xu, Yue Wang, Chujie Li, Tao Han, Haiming Chen, Wenxue Chen… in AAPS Open (2023)

Article

RIPK1 inhibition contributes to lysosomal membrane stabilization in ischemic astrocytes via a lysosomal Hsp70.1B-dependent mechanism

Receptor-interacting protein kinase 1 (RIPK1) contributes to necroptosis. Our previous study showed that pharmacological or genetic inhibition of RIPK1 protects against ischemic stroke-induced astrocyte injury...

Hua-** Du, Yi Guo, Yong-ming Zhu, De-fei Gao, Bo Lin… in Acta Pharmacologica Sinica (2023)

Article

Author Correction: Wogonin suppresses osteopontin expression in adipocytes by activating PPARα

Ye-min Zhang, Ming-xin Li, Zhao Tang, Chang-hua Wang in Acta Pharmacologica Sinica (2023)

Article

Purinergic receptors mediate endothelial dysfunction and participate in atherosclerosis

Atherosclerosis is the main pathological basis of cardiovascular disease and involves damage to vascular endothelial cells (ECs) that results in endothelial dysfunction (ED). The vascular endothelium is the ke...

**an-Ming Wu, Ning Zhang, Jiang-Shan Li, Zhi-Hong Yang… in Purinergic Signalling (2023)

Article

Andrographolide ameliorates hepatic steatosis by suppressing FATP2-mediated fatty acid uptake in mice with nonalcoholic fatty liver disease

Excessive intrahepatocellular lipid accumulation or steatosis is caused by abnormal lipid metabolism and a common character of nonalcoholic fatty liver disease (NAFLD), which may progress into cirrhosis and he...

Li-Sha Ran, Ya-Zeng Wu, Yi-Wen Gan, Hong-Lian Wang… in Journal of Natural Medicines (2023)

Article

Hederacoside C ameliorates colitis via restoring impaired intestinal barrier through moderating S100A9/MAPK and neutrophil recruitment inactivation

Hederacoside C (HSC) has attracted much attention as a novel modulator of inflammation, but its anti-inflammatory mechanism remains elusive. In the present study, we investigated how HSC attenuated intestinal ...

Zheng-xia Zha, Yu Lin, Ke-xin Wang, Yan-lin Zhang, Dan Li… in Acta Pharmacologica Sinica (2023)

Article

Activating α7nAChR ameliorates abdominal aortic aneurysm through inhibiting pyroptosis mediated by NLRP3 inflammasome

Abdominal aortic aneurysm (AAA) is defined as a dilated aorta in diameter at least 1.5 times of a normal aorta. Our previous studies found that activating α7 nicotinic acetylcholine receptor (α7nAChR) had a pr...

Hui Fu, Qi-rui Shen, Yi Zhao, Min Ni, Can-can Zhou… in Acta Pharmacologica Sinica (2022)

Article

NFAT inhibitor 11R-VIVIT ameliorates mouse renal fibrosis after ischemia-reperfusion-induced acute kidney injury

Acute kidney injury (AKI) with maladaptive tubular repair leads to renal fibrosis and progresses to chronic kidney disease (CKD). At present, there is no curative drug to interrupt AKI-to-CKD progression. The ...

Zhi-yong **e, Wei Dong, Li Zhang, Meng-jie Wang… in Acta Pharmacologica Sinica (2022)

Article

Correction to: KCNQ1OT1 Exacerbates Ischemia–Reperfusion Injury Through Targeted Inhibition of miR-140-3P

Ming Yi, Yue Li, Dan Wang, Qiuxia Zhang, Li Yang, Chunsheng Yang in Inflammation (2022)

Article

Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma

HDAC inhibitors (HDACis) have been intensively studied for their roles and potential as drug targets in T-cell lymphomas and other hematologic malignancies. Bisthianostat is a novel bisthiazole-based pan-HDACi...

Yu-bo Zhou, Yang-ming Zhang, Hong-hui Huang, Li-**g Shen… in Acta Pharmacologica Sinica (2022)

Article

Methylene blue prevents osteoarthritis progression and relieves pain in rats via upregulation of Nrf2/PRDX1

Oxidative stress-related cartilage degeneration, synovitis, and joint pain play vital roles in the progress of osteoarthritis (OA). Anti-oxidative stress agents not only prevent structural damage progression b...

Jia-wei Li, Rong-liang Wang, Jia Xu, Kuo-yang Sun… in Acta Pharmacologica Sinica (2022)

Article

TRIP6 promotes inflammatory damage via the activation of TRAF6 signaling in a murine model of DSS-induced colitis

TRIP6 is a zyxin family member that serves as an adaptor protein to regulate diverse biological processes. In prior reports, TRIP6 was shown to play a role in regulating inflammation. However, its in vivo role...

Yun Yang, **u-Ming Li, **g-Ru Wang, Yan Li, Wen-Long Ye… in Journal of Inflammation (2022)

Article

Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease

Diabetic kidney disease (DKD) is one of the microvascular complications of diabetes mellitus and a major cause of end-stage renal disease with limited treatment options. Wogonin is a flavonoid derived from the...

Xue-qi Liu, Ling Jiang, Yuan-yuan Li, Yue-bo Huang, Xue-ru Hu… in Acta Pharmacologica Sinica (2022)

Article

VEGFA mRNA for regenerative treatment of heart failure

Anna Collén, Nils Bergenhem, Leif Carlsson… in Nature Reviews Drug Discovery (2022)

Article

Author Correction: Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-γ

A Correction to this paper has been published: https://doi.org/10.1038/s41401-020-00592-2

Ya-kun Meng, Chun-yu Li, Rui-yu Li, Lan-zhi He, He-rong Cui… in Acta Pharmacologica Sinica (2021)

Article

Dexmedetomidine hydrochloride inhibits hepatocyte apoptosis and inflammation by activating the lncRNA TUG1/miR-194/SIRT1 signaling pathway

Liver injury seriously threatens the health of people. Meanwhile, dexmedetomidine hydrochloride (DEX) can protect against liver injury. However, the mechanism by which Dex mediates the progression of liver inj...

**ao-**a Gu, **ao-**a Xu, Hui-Hua Liao, Ruo-Na Wu… in Journal of Inflammation (2021)

Article

Correction to: Central Blockade of E-Prostanoid 3 Receptor Ameliorated Hypertension Partially by Attenuating Oxidative Stress and Inflammation in the Hypothalamic Paraventricular Nucleus of Spontaneously Hypertensive Rats

The original version of this article unfortunately contained a mistake in the name of one co-author. The correct name of the co-author “Juan Ba” should be “Juan Bai”.

Fang-Fang Wang, Juan Bai, **ao-**g Yu, **ao-Lian Shi… in Cardiovascular Toxicology (2021)

Article

Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives

The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) and an ongoing severe pandemic. Curative drugs specific for COVID-19 are currently lacking. Chl...

**ao-lei Zhang, Zhuo-ming Li, Jian-tao Ye, **g Lu… in Acta Pharmacologica Sinica (2020)

Article

β-sitosterol ameliorates influenza A virus-induced proinflammatory response and acute lung injury in mice by disrupting the cross-talk between RIG-I and IFN/STAT signaling

β-Sitosterol (24-ethyl-5-cholestene-3-ol) is a common phytosterol Chinese medical plants that has been shown to possess antioxidant and anti-inflammatory activity. In this study we investigated the effects of ...

Bei-xian Zhou, **g Li, **ao-li Liang, ** Pan… in Acta Pharmacologica Sinica (2020)

Article

Publisher Correction: Integrating yeast chemical genomics and mammalian cell pathway analysis

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Fu-lai Zhou, Sheena C Li, Yue Zhu, Wan-**g Guo, Li-jun Shao… in Acta Pharmacologica Sinica (2020)