93 Result(s)

Article

Exploring the inverse relationship between serum total bilirubin and systemic immune-inflammation index: insights from NHANES data (2009–2018)

Bilirubin is known for its multifaceted attributes, including antioxidant, anti-inflammatory, immunomodulatory, and antiapoptotic properties. The systemic immune-inflammation index (SII) is a recent marker tha...

Shan-Shan Huang, Yi Ding, **ao-Na Yi, Hai-Yan Mao… in European Journal of Medical Research (2024)

Article

Sodium tanshinone IIA sulfonate protects vascular relaxation in ApoE-knockout mice by inhibiting the SYK-NLRP3 inflammasome-MMP2/9 pathway

Hyperlipidemia damages vascular wall and serves as a foundation for diseases such as atherosclerosis, hypertension and stiffness. The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is ...

Hai-Hua Liu, Wei Wei, Fei-Fei Wu, Lu Cao, Bing-Jie Yang… in BMC Cardiovascular Disorders (2024)

Article

Hemothorax caused by injury of musculophrenic artery after ultrasound-guided percutaneous liver biopsy: a case report

Hemorrhage is the most common major complication after liver biopsy. Hemothorax is one type of bleeding and is very rare and dangerous. Several cases of hemothorax subsequent to liver biopsy have been document...

**g-ru Yang, Sai Wu, Jian Li, **ao-juan Tian… in Journal of Medical Case Reports (2024)

Article

XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...

Qiu-Zhong Pan, **g-**g Zhao, Liang Liu… in Signal Transduction and Targeted Therapy (2024)

Article

A nomogram model for predicting intramyocardial hemorrhage post-PCI based on SYNTAX score and clinical features

The aim of this study is to develop a nomogram model for predicting the occurrence of intramyocardial hemorrhage (IMH) in patients with Acute Myocardial Infarction (AMI) following Percutaneous Coronary Interve...

Yin-shuang Yang, De-yang **, Yang Duan, Miao Yu, Kai Liu… in BMC Cardiovascular Disorders (2024)

Article

Neutrophil-to-lymphocyte ratio associated with symptomatic saccular unruptured intracranial aneurysm

Whether symptomatic unruptured intracranial aneurysms (UIAs) lead to change in circulating inflammation remains unclear. This study aims to evaluate the role of hematological inflammatory indicators in predict...

De-**ang Zheng, Yi-Yang Lv, **ao-**g Zhang… in European Journal of Medical Research (2024)

Article

Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study

This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive (N) and nivolumab–chemotherapy (N/C) combinations based on PD-L1 expression. Eligible patients exh...

Si-Yang Liu, Song Dong, Xue-Ning Yang… in Signal Transduction and Targeted Therapy (2023)

Article

A real-world case–control study on the efficacy and safety of pulsed field ablation for atrial fibrillation

The primary objective of this study was to evaluate the efficacy and safety of pulsed field ablation in individuals diagnosed with atrial fibrillation.

Ming Yang, Peng-yu Wang, Ying-lu Hao, Mei Liang… in European Journal of Medical Research (2023)

Article

Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients

The Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infected a substantial proportion of Chinese population, and understanding the factors underlying the severity of the dis...

Lin Wang, Jia-Bao Cao, Bin-Bin **a, Yue-Juan Li… in Signal Transduction and Targeted Therapy (2023)

Article

Correction: PBK phosphorylates MSL1 to elicit epigenetic modulation of CD276 in nasopharyngeal carcinoma

Meng-Yao Wang, Bin Qi, Fang Wang, Zhi-Rui Lin, Ming-Yi Li, Wen-**g Yin… in Oncogenesis (2023)

Article

Dynamic single-cell map** unveils Epstein‒Barr virus-imprinted T-cell exhaustion and on-treatment response

Epstein‒Barr virus (EBV)-associated gastric cancer (GC) manifests an intriguing immunotherapy response. However, the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined...

Miao-Zhen Qiu, Chaoye Wang, Zhiying Wu, Qi Zhao… in Signal Transduction and Targeted Therapy (2023)

Article

ASCL2 induces an immune excluded microenvironment by activating cancer-associated fibroblasts in microsatellite stable colorectal cancer

Proficient mismatch repair or microsatellite stable (pMMR/MSS) colorectal cancers (CRCs) are vastly outnumbered by deficient mismatch repair or microsatellite instability-high (dMMR/MSI-H) tumors and lack a re...

Dan Zhang, Qi-Qi Ni, Qiao-Yan Liang, Li-Ling He, Bo-Wen Qiu, Ling-Jie Zhang… in Oncogene (2023)

Article

CDK7-YAP-LDHD axis promotes D-lactate elimination and ferroptosis defense to support cancer stem cell-like properties

Reprogrammed cellular metabolism is essential for maintaining cancer stem cells (CSCs) state. Here, we report that mitochondrial D-lactate catabolism is a necessary initiating oncogenic event during tumorigene...

Mengzhu Lv, Ying Gong, Xuesong Liu, Yan Wang… in Signal Transduction and Targeted Therapy (2023)

Article

Comparisons of perioperative and long-term outcomes of laparoscopic versus open gastrectomy for advanced gastric cancer after neoadjuvant therapy: an updated pooled analysis of eighteen studies

Outcomes of laparoscopic surgery in advanced gastric cancer patients who received neoadjuvant therapy represent a controversial issue. We performed an updated meta-analysis to evaluate the perioperative and lo...

Hua-Yang Pang, **u-Feng Chen, Li-Hui Chen… in European Journal of Medical Research (2023)

Article

Retraction Note: Hsp90β promotes aggressive vasculogenic mimicry via epithelial–mesenchymal transition in hepatocellular carcinoma

**g Meng, Shuang Chen, Yue-yang Lei, **g-xia Han, Wei-long Zhong… in Oncogene (2023)

Article

Serine/threonine kinase TBK1 promotes cholangiocarcinoma progression via direct regulation of β-catenin

Cholangiocarcinoma (CCA) is a highly heterogeneous and metastatic malignancy with a poor prognosis even after curative hepatectomy. Studies exploring its pathogenesis and identifying effective therapeutic targ...

Chong-Qing Gao, Zhen-Zhen Chu, Di Zhang, Yang **ao, **ng-Yan Zhou, Jun-Ru Wu… in Oncogene (2023)

Article

Erlotinib versus gemcitabine plus cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-cell lung cancer: final overall survival analysis of the EMERGING-CTONG 1103 randomised phase II trial

EMERGING-CTONG 1103 showed improved progression-free survival (PFS) with neoadjuvant erlotinib vs. chemotherapy for patients harbouring EGFR sensibility mutations and R0 resected stage IIIA-N2 non-small cell l...

Wen-Zhao Zhong, Hong-Hong Yan, Ke-Neng Chen… in Signal Transduction and Targeted Therapy (2023)