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Article
Open AccessApplication of multiple-finding segmentation utilizing Mask R-CNN-based deep learning in a rat model of drug-induced liver injury
Drug-induced liver injury (DILI) presents significant diagnostic challenges, and recently artificial intelligence-based deep learning technology has been used to predict various hepatic findings. In this study...
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Article
Open AccessTelecommuting-related health outcomes during the COVID-19 pandemic in South Korea: a national population-based cross-sectional study
Telecommuting has expanded greatly during the COVID-19 pandemic. Since the advent of remote working from home, there has been an ongoing controversy about the positive or negative health-related impact of tele...
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Article
Open AccessVisual prognosis and surgical timing of Ahmed glaucoma valve implantation for neovascular glaucoma secondary to diabetic vitrectomy
Evaluate the visual outcomes of Ahmed glaucoma valve implantation (AGVI) in patients with neovascular glaucoma (NVG) who underwent diabetic vitrectomy and suggest appropriate AGVI timing.
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Article
Open AccessEfficacy and safety of 5% lidocaine patches for postoperative pain management in patients undergoing unilateral inguinal hernia repair: study protocol for a prospective, double-blind, randomized, controlled clinical trial
Acute postoperative pain is a common complication of inguinal hernia repair. Pain management using local application of anesthetic agents over the skin surrounding the surgical incision may reduce the requirem...
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Article
Modeling and Performance Analysis of Linear Part Feeder System Actuated by Piezoelectric Transducers
In this research, a piezoelectric linear part feeder system that transports tiny parts is modeled, and its performance is analyzed. Design parameters affecting the part feeding velocity of a linear part feeder...
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Article
Open AccessHemistepsin A suppresses colorectal cancer growth through inhibiting pyruvate dehydrogenase kinase activity
Most cancer cells primarily produce their energy through a high rate of glycolysis followed by lactic acid fermentation even in the presence of abundant oxygen. Pyruvate dehydrogenase kinase (PDK) 1, an enzyme...
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Article
Open Access6′-Sialylgalactose inhibits vascular endothelial growth factor receptor 2-mediated angiogenesis
Angiogenesis should be precisely regulated because disordered neovascularization is involved in the aggravation of multiple diseases. The vascular endothelial growth factor (VEGF)-A/VEGF receptor 2 (VEGFR-2) a...
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Article
Open AccessA Novel Lactate Dehydrogenase Inhibitor, 1-(Phenylseleno)-4-(Trifluoromethyl) Benzene, Suppresses Tumor Growth through Apoptotic Cell Death
The Warburg effect, wherein cancer cells prefer glycolysis rather than oxidative phosphorylation even under normoxic conditions, is a major characteristic of malignant tumors. Lactate dehydrogenase A (LDHA) is...
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Article
Open AccessExperimental Tracheal Replacement Using 3-dimensional Bioprinted Artificial Trachea with Autologous Epithelial Cells and Chondrocytes
Various treatment methods for tracheal defects have been attempted, such as artificial implants, allografts, autogenous grafts, and tissue engineering; however, no perfect method has been established. We attem...
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Article
Genome-wide analysis of Hanwoo and Chikso populations using the BovineSNP50 genoty** array
Hanwoo and Chikso are classified as Korean native cattle breeds that are currently registered with the Food and Agriculture Organization. However, there is still a lack of genomic studies to compare Hanwoo to ...
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Article
Open AccessCordycepin induces apoptosis of human ovarian cancer cells by inhibiting CCL5-mediated Akt/NF-κB signaling pathway
The chemokine, CCL5, is a key mediator for the recruitment of immune cells into tumors and tissues. Akt/NF-κB signaling is significantly activated by CCL5. However, the role of NF-κB inactivation in apoptosis ...
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Article
Open AccessDistribution characteristic of invasive alien plants in Jeju Island
This study was undertaken to analyze the distribution and ecological characteristics of invasive alien plant species on Jeju Island, and to provide basic data for their management and control.
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Article
Heat treatment response of TiC-reinforced steel matrix composite
A particulate TiC-reinforced SKD11 steel matrix composite is fabricated by using a pressure infiltration casting, achieving a homogeneous distribution of the particles with 60 vol%. The retained austenite frac...
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Article
Open AccessXXIV World Allergy Congress 2015
A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts
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Article
Open AccessThe effect of castration time on growth and carcass production of elk bulls
The effects of castration time on growth and carcass traits of elk bulls were investigated. Twelve bulls at 5 years old were raised and fed on concentrate with ad libitum hay. All animals were allocated randomly ...
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Article
Pharmacokinetic scaling of epirubicin using allometric and species-invariant time methods
The pharmacokinetics of epirubicin, an anthracycline, were investigated after intravenous bolus administration (5 mg/kg) in mice, rats, rabbits and dogs. Based on animal data, we predicted the following human ...
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Article
Analysis of cytokine production in a newly developed canine tracheal epithelial cell line infected with H3N2 canine influenza virus
The Madin-Darby canine kidney (MDCK) cell line is typically used to analyze pathological features after canine influenza virus (CIV) infection. However, MDCK cells are not the ideal cell type, because they are...
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Chapter and Conference Paper
5 DOF Industrial Robot Arm for Safe Human-Robot Collaboration
Collision safety is very important when it comes to human-robot collaboration. However, most of the industrial robots are equipped with large capacity motors for high performance, which on the contrary, increa...
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Article
Hepatic uptake of epirubicin by isolated rat hepatocytes and its biliary excretion after intravenous infusion in rats
Anthracycline anticancer agents are widely used in the cancer chemotherapy for hepatocelluar carcinoma. However, accurate kinetic analyses of the hepatocellular uptake and efflux of the drugs have not been rep...
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Article
Open AccessClearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients
Here, we demonstrate that electroporation-enhanced immunization with a rationally designed HPV DNA vaccine (GX-188E), preferentially targeting HPV antigens to dendritic cells, elicits a significant E6/E7-speci...
