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Article
Open AccessEvaluation of the FPMC respiratory panel for detection of respiratory tract pathogens in nasopharyngeal swab and sputum specimens
The performance of the new Respiratory Pathogen panel (fluorescent probe melting curve, FPMC) for the qualitative detection of 12 organisms (chlamydia pneumoniae, mycoplasma pneumoniae, adenovirus, influenza A...
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Article
Open AccessYTHDC1 aggravates high glucose-induced retinal vascular endothelial cell injury via m6A modification of CDK6
Retinal vascular endothelial cell (RVECs) injury is a major cause of morbidity and mortality among the patients with diabetes. RVECs dysfunction is the predominant pathological manifestation of vascular compli...
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Article
Open AccessReducing nonradiative recombination for highly efficient inverted perovskite solar cells via a synergistic bimolecular interface
Reducing interface nonradiative recombination is important for realizing highly efficient perovskite solar cells. In this work, we develop a synergistic bimolecular interlayer (SBI) strategy via 4-methoxypheny...
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Article
Biocontrol potential of plant growth-promoting rhizobacteria against plant disease and insect pest
Biological control is a promising approach to enhance pathogen and pest control to ensure high productivity in cash crop production. Therefore, PGPR biofertilizers are very suitable for application in the cult...
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Article
Open AccessCombination of MRI-based prediction and CRISPR/Cas12a-based detection for IDH genoty** in glioma
Early identification of IDH mutation status is of great significance in clinical therapeutic decision-making in the treatment of glioma. We demonstrate a technological solution to improve the accuracy and reli...
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Article
Open AccessExploring hot topics and evolutionary paths in the Diagnosis-Related Groups (DRGs) field: a comparative study using LDA modeling
This study reviews the research status of Diagnosis-related groups (DRGs) payment system in China and globally by analyzing topical issues in this field and exploring the evolutionary trends of DRGs in differe...
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Article
Open AccessIntegration of transcriptomics, metabolomics, and hormone analysis revealed the formation of lesion spots inhibited by GA and CTK was related to cell death and disease resistance in bread wheat (Triticum aestivum L.)
Wheat is one of the important grain crops in the world. The formation of lesion spots related to cell death is involved in disease resistance, whereas the regulatory pathway of lesion spot production and resis...
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Article
Open AccessMAL2 reprograms lipid metabolism in intrahepatic cholangiocarcinoma via EGFR/SREBP-1 pathway based on single-cell RNA sequencing
Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive cancer characterized by a poor prognosis and resistance to chemotherapy. In this study, utilizing scRNA-seq, we discovered that the tetra-transmembr...
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Article
Open AccessPhylodynamics unveils invading and diffusing patterns of dengue virus serotype-1 in Guangdong, China from 1990 to 2019 under a global genoty** framework
The strong invasiveness and rapid expansion of dengue virus (DENV) pose a great challenge to global public health. However, dengue epidemic patterns and mechanisms at a genetic scale, particularly in term of c...
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Article
Open AccessGasdermin D silencing alleviates airway inflammation and remodeling in an ovalbumin-induced asthmatic mouse model
Emerging evidence demonstrates that pyroptosis has been implicated in the pathogenesis of asthma. Gasdermin D (GSDMD) is the pyroptosis executioner. The mechanism of GSDMD in asthma remains unclear. The aim of...
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Article
Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas
Bruton’s tyrosine kinase (BTK) has emerged as a therapeutic target for B-cell malignancies, which is substantiated by the efficacy of various irreversible or reversible BTK inhibitors. However, on-target BTK m...
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Article
Transmission scheduling of P2P real-time communication based on restless multi-armed bandit
In this paper, we consider a transmission scheduling problem of the point-to-point (P2P) real-time communication over fading channel. Specifically, we assume each transmission task with a strict time delay arr...
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Article
Effect of Magnesium Content on Precipitation Behavior of TiN-Containing Inclusions in High-Titanium High-Strength Steel
High-temperature melting experiments (1600 °C), metallographic microscopy and scanning electron microscopy were used to investigate the morphology, quantity and size of TiN in the center of high-titanium high-...
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Article
NIR-II light in clinical oncology: opportunities and challenges
Novel strategies utilizing light in the second near-infrared region (NIR-II; 900–1,880 nm wavelengths) offer the potential to visualize and treat solid tumours with enhanced precision. Over the past few decade...
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Article
Tertiary orientation structures enhance the piezoelectricity of MXene/PVDF nanocomposite
With the increasing demand for flexible piezoelectric sensor components, research on polyvinylidene fluoride (PVDF) based piezoelectric polymers is mounting up. However, the low dipole polarization and disorde...
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Article
Photocatalytic removal of ammonia nitrogen from water: investigations and challenges for enhanced activity
Ammonia nitrogen (NH3-N/NH4+-N) serves as a crucial chemical in biochemistry and fertilizer synthesis. However, it is also a toxic compound, posing risks from eutrophication to direct threats to human health. Amm...
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Article
Short-Term Prediction of Groundwater Level Based on Spatiotemporal Correlation
Groundwater is an important component of water resources. Excessive exploitation can lead to water scarcity, while excessive groundwater can cause problems such as terrain collapse. Therefore, it is crucial to...
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Article
Injectable ultrasonic sensor for wireless monitoring of intracranial signals
Direct and precise monitoring of intracranial physiology holds immense importance in delineating injuries, prognostication and averting disease1. Wired clinical instruments that use percutaneous leads are accurat...
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Article
Open AccessBrain development in newborns and infants after ECMO
Extracorporeal membrane oxygenation (ECMO) not only significantly improves survival rates in severely ill neonates but also is associated with long-term neurodevelopmental issues. To systematically review the ...
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Article
The SOX2/PDIA6 axis mediates aerobic glycolysis to promote stemness in non-small cell lung cancer cells
Non-small cell lung cancer (NSCLC) is an aggressive and rapidly expanding lung cancer. Abnormal upregulation or knockdown of PDIA6 expression can predict poor prognosis in various cancers. This study aimed to ...
