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Open AccessA prospective, open-label, randomized clinical trial to evaluate the efficacy and safety of remimazolam in patients undergoing EBUS-TBNA: REST trial design
Remimazolam is safe and effective for moderate sedation during flexible bronchoscopy, but its safety and efficacy during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) remains und...
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Article
Open AccessITC-6102RO, a novel B7-H3 antibody-drug conjugate, exhibits potent therapeutic effects against B7-H3 expressing solid tumors
The B7-H3 protein, encoded by the CD276 gene, is a member of the B7 family of proteins and a transmembrane glycoprotein. It is highly expressed in various solid tumors, such as lung and breast cancer, and has ...
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Article
Open AccessInhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair
Diabetic wound healing, including diabetic foot ulcer (DFU), is a serious complication of diabetes. Considering the complexity of DFU development, the identification of a factor that mediates multiple pathogen...
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Article
Prediction Model for Screening Patients at Risk of Malnutrition After Gastric Cancer Surgery
Malnutrition after gastrectomy is associated with a poor prognosis; however, no accurate model for predicting post-gastrectomy malnutrition exists. Hence, we conducted a retrospective study to develop a predic...
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Article
Open AccessClinical characteristics and disease progression of retinitis pigmentosa associated with PDE6B mutations in Korean patients
Due to the genotype–phenotype heterogeneity in retinitis pigmentosa (RP), molecular diagnoses and prediction of disease progression is difficult. This study aimed to report ocular and genetic data from Korean ...
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Article
Open AccessTranscriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma
Glioblastoma (GBM) is a complex disease with extensive molecular and transcriptional heterogeneity. GBM can be subcategorized into four distinct subtypes; tumors that shift towards the mesenchymal phenotype up...
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Article
Spatiotemporal genomic architecture informs precision oncology in glioblastoma
Raul Rabadan, Woong-Yang Park, Do-Hyun Nam and colleagues examine the genomic and transcriptomic profiles of tumors from 52 patients with glioblastoma using both bulk and single-cell analyses. They find that t...
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Article
Long and short sleep duration are both associated with suicidal ideation in Korean employees
The aim of this study was to investigate the association between self-reported sleep duration and suicidal ideation in Korean employees. We studied 204,629 employees who attended health screenings in 2014. Tot...
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Article
Open AccessPositive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification
p53 plays a pivotal role in tumour suppression under stresses, such as DNA damage. ISG15 has been implicated in the control of tumorigenesis. Intriguingly, the expression of ISG15, UBE1L and UBCH8 is induced b...
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Article
Open AccessXXIV World Allergy Congress 2015
A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts
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Article
Prevalence of avian influenza virus in wild birds before and after the HPAI H5N8 outbreak in 2014 in South Korea
Since 2003, highly pathogenic avian influenza (HPAI) virus outbreaks have occurred five times in Korea, with four HPAI H5N1 outbreaks and one HPAI H5N8 outbreak. Migratory birds have been suggested to be the f...
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Article
Riboflavin photo-transformation of genistein and changes in radical scavenging activities of photo-transformed genistein derivatives
Genistein was treated with riboflavin photosensitization and the radical scavenging activities of mixtures of genistein and riboflavin were determined using DPPH and ABTS assays. For a period of light irradiat...
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Open AccessBobby Sox homology regulates odontoblast differentiation of human dental pulp stem cells/progenitors
Transcription factors have been implicated in regulating the differentiation of odontoblasts from dental pulp stem cells/progenitors (DPSCs/progenitors), but their regulatory network is not completely understood.
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MicroRNA-146a suppresses metastatic activity in brain metastasis
Primary lung tumors, breast tumors, and melanoma metastasize mainly in the brain where therapy is limited to surgery and radiation. To investigate the molecular basis of brain metastases, we isolated brain-tro...
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Article
Production of ketocarotenoids in transgenic carrot plants with an enhanced level of β-carotene
One of the drawbacks in inducing the synthesis of ketocarotenoids in transgenic plants is the accompanying decrease in β-carotene level, especially in transgenic plants overexpressing only a β-carotene ketolas...
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Article
A sweetpotato SRD1 promoter confers strong root-, taproot-, and tuber-specific expression in Arabidopsis, carrot, and potato
Harvestable, starch-storing organs of plants, such as fleshy taproots and tubers, are important agronomic products that are also suitable target organs for use in the molecular farming of recombinant proteins ...
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Article
Erratum to: Clinical importance of Bcl-6-positive non-deep-site involvement in non-HIV-related primary central nervous system diffuse large B-cell lymphoma
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Clinical importance of Bcl-6-positive non-deep-site involvement in non-HIV-related primary central nervous system diffuse large B-cell lymphoma
In several studies of primary central nervous system lymphoma (PCNSL), deep-site involvement of the brain, as well as age and performance status (PS), were found to be independent prognostic factors. In immuno...
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Article
A possible association of EMID2 polymorphisms with aspirin hypersensitivity in asthma
Aspirin-intolerant asthma (AIA) is an asthma phenotype characterized by the development of bronchoconstriction following ingestion of aspirin. Despite the well-defined pathological trigger, the underlying mech...
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Article
On drag coefficient parameterization with post processed direct fluxes measurements over the ocean
This study presents an evaluation of the atmospheric factors influencing the post-processing for fast-response data of horizontal momentum, vertical wind component, temperature, and water vapor to measure turb...
