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  1. Article

    Open Access

    Multicenter study on clinical outcomes and poor prognostic factors in patients with Klebsiella pneumoniae bacteremia receiving cefoperazone/sulbactam treatment

    Infections caused by Klebsiella pneumoniae are common and result in high mortality rates. In vitro studies demonstrated the potency of cefoperazone/sulbactam (CPZ/SUL) against Klebsiella pneumoniae. However, the ...

    Tsung-Ta Chiang, Ming-Hsien Chiang in European Journal of Clinical Microbiology … (2024)

  2. No Access

    Article

    2D photonic-crystal-type surface relief grating for light with an azimuth angle

    With the development of virtual reality, the projection design of the head-mounted display (HMD) requires improvement as well. The surface relief grating (SRG) is one of the popular diffraction elements to ach...

    Fu-Li Hsiao, Chien-Teng Lin, Yen-Tung Yang, Yi-Chia Huang, Li-Chuan Yu in Optical Review (2024)

  3. No Access

    Article

    Clinical outcomes of carbapenem-resistant gram-negative bacterial bloodstream infection in patients with end-stage renal disease in intensive care units: a multicenter retrospective observational study

    Carbapenem-resistant gram-negative bacteria (CRGNB) present a considerable global threat due to their challenging treatment and increased mortality rates, with bloodstream infection (BSI) having the highest mo...

    Yu-Chao Lin, Kuang-Yao Yang, Chung-Kan Peng, Ming-Cheng Chan, Chau-Chyun Sheu in Infection (2024)

  4. Article

    Open Access

    CPEB2-activated axonal translation of VGLUT2 mRNA promotes glutamatergic transmission and presynaptic plasticity

    Local translation at synapses is important for rapidly remodeling the synaptic proteome to sustain long-term plasticity and memory. While the regulatory mechanisms underlying memory-associated local translatio...

    Wen-Hsin Lu, Tzu-Tung Chang, Yao-Ming Chang, Yi-Hsiang Liu in Journal of Biomedical Science (2024)

  5. Article

    Open Access

    A review on the cultivation, bioactive compounds, health-promoting factors and clinical trials of medicinal mushrooms Taiwanofungus camphoratus, Inonotus obliquus and Tropicoporus linteus

    Medicinal mushrooms, such as Taiwanofungus camphoratus, Inonotus obliquus, and Tropicoporus linteus, have been used in traditional medicine for therapeutic purposes and promotion of overall health in China and ma...

    Phoebe Yon Ern Tee, Thiiben Krishnan, **n Tian Cheong in Fungal Biology and Biotechnology (2024)

  6. No Access

    Article

    The obesity-related mutation gene on nonalcoholic fatty liver disease

    The prevalence of overweight and obesity is increasing, leading to metabolic-associated fatty liver disease (MAFLD) characterized by excessive accumulation of liver fat and a risk of develo** hepatocellular ...

    Yen-Yu Chen, Chi-Sheng Chen, Jee-Fu Huang, Wen-Hsiu Su, Chia-Yang Li in Human Genetics (2024)

  7. Article

    Open Access

    Psychometric validation of the Chinese Version of the stimulant relapse risk scale (SRRS) in patients with methamphetamine use disorder

    Evaluating the risk of relapse is a pivotal step in the treatment of patients with methamphetamine use disorder (MUD). The 30-item Stimulant Relapse Risk Scale (SRRS) was originally developed in Japan to meet ...

    **g-Shu Lin, Yasukazu Ogai, Chun Lin in Substance Abuse Treatment, Prevention, and… (2024)

  8. Article

    Retraction Note: Role of energy consumption and sustainability-oriented eco-innovation on economic growth: evidence from Middle Eastern economy

    Yu-Te Tu, Chia-Yang Lin, Syed Ehsanullah in Environmental Science and Pollution Resear… (2024)

  9. No Access

    Article

    Benefits of Hepatitis C Viral Eradication: A Real-World Nationwide Cohort Study in Taiwan

    Chronic hepatitis C (CHC) increases the risk of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). This nationwide cohort study assessed the effectiveness of viral eradication of CHC.

    Chin-Wei Chang, Wei-Fan Hsu, Kuo-Chih Tseng, Chi-Yi Chen in Digestive Diseases and Sciences (2024)

  10. Article

    Open Access

    Optimizing immunofluorescence with high-dynamic-range imaging to enhance PD-L1 expression evaluation for 3D pathology assessment from NSCLC tumor tissue

    Assessing programmed death ligand 1 (PD-L1) expression through immunohistochemistry (IHC) is the golden standard in predicting immunotherapy response of non-small cell lung cancer (NSCLC). However, observation...

    Hsien-Neng Huang, Chun-Wei Kuo, Yu-Ling Hung, Chia-Hung Yang in Scientific Reports (2024)

  11. Article

    Open Access

    Tumor-intrinsic IFNα and CXCL10 are critical for immunotherapeutic efficacy by recruiting and activating T lymphocytes in tumor microenvironment

    Tumor immunotherapies targeting PD-(L)1 exhibit anti-tumor efficacy in only 10–30% of patients with various cancers. Literature has demonstrated that a “hot tumor” which contains high T lymphocytes in the tumo...

    Chun-Chia Cheng, Jungshan Chang, Ai-Sheng Ho in Cancer Immunology, Immunotherapy (2024)

  12. Article

    Open Access

    Nanosheet integration of induced tunnel field-effect transistor with lower cost and lower power

    Nanosheet transistors are poised to become the preferred choice for the next generation of smaller-sized devices in the future. To address the future demand for high-performance and low-power computing applica...

    Jyi-Tsong Lin, Chia-Yo Kuo in Discover Nano (2024)

  13. No Access

    Article

    Early Therapeutic Drug Monitoring Optimizes Teicoplanin Use in Febrile Neutropenic Patients with Hematological Malignancies

    A target trough concentration (Cmin) of teicoplanin ≥ 15–20 mg/L between the fourth and sixth day has been suggested for severe infections or management of febrile neutropenia (FN). Owing to no reports discussing...

    Yu-Wen Wang, Hsin-An Hou, Chien-Chin Lin, Hsing-Yu Lin, Pin-Zi Chen in Advances in Therapy (2024)

  14. Article

    Open Access

    Artificial Intelligence Application in Skull Bone Fracture with Segmentation Approach

    This study aims to evaluate an AI model designed to automatically classify skull fractures and visualize segmentation on emergent CT scans. The model’s goal is to boost diagnostic accuracy, alleviate radiologi...

    Chia-Yin Lu, Yu-Hsin Wang, Hsiu-Ling Chen in Journal of Imaging Informatics in Medicine (2024)

  15. No Access

    Article

    Demographics and medical burden of osteogenesis imperfecta: a nationwide database analysis

    The epidemiological data on osteogenesis imperfecta (OI) in Asia is limited. This study, representing the first comprehensive epidemiological investigation on OI in Taiwan, reveals high medical resource utiliz...

    Chien-An Shih, Chia-Chun Li, Yin-Fan Chang, Jawl-Shan Hwang in Osteoporosis International (2024)

  16. No Access

    Article

    Temporal Trends of Inflammatory Bowel Diseases in Taiwan from 2016 to 2020: A Population-Based Study

    There are scanty population-based studies investigating the incidence and prevalence rates of inflammatory bowel disease (IBD) in Taiwan.

    Chia-Jung Kuo, Cheng-Yu Lin, Puo-Hsien Le, Yao-Wei Kuo in Digestive Diseases and Sciences (2024)

  17. Article

    Open Access

    Develo** an entrustable professional activity for providing health education and consultation in occupational therapy and examining its validity

    Entrustable Professional Activities (EPA)-based assessment is easily and intuitively used in evaluating the learning outcomes of competency-based medical education (CBME). This study aimed to develop an EPA fo...

    Chung-Pei Fu, Ching-Kai Huang, Yi-Chiun Yang, Wei-Sheng Liao in BMC Medical Education (2024)

  18. Article

    Open Access

    Understanding and alleviating informal caregiver burden through the development and validation of a caregiver strain index-based model in Taiwan

    Quantifying the informal caregiver burden is important for understanding the risk factors associated with caregiver overload and for evaluating the effectiveness of services provided in Long-term Care (LTC).

    Shuo-Chen Chien, Yu-Hung Chang, Chia-Ming Yen, Ying-Erh Chen in BMC Geriatrics (2024)

  19. Article

    Open Access

    Synergizing MBR and MCDI systems as a sustainable solution for decentralized wastewater reclamation and reuse

    Decentralized wastewater reclamation and reuse systems have drawn much attention due to their capability for reducing the energy demand for water conveyance and reclaiming wastewater for local re-use. While me...

    Wang-Sheng Yu, Huei-Cih Liu, Hsin-Chieh Lin in Sustainable Environment Research (2024)

  20. No Access

    Article

    Correlation of altered intrinsic functional connectivity with impaired self-regulation in children and adolescents with ADHD

    Attention-deficit hyperactivity disorder (ADHD) has a high prevalence of co-occurring impaired self-regulation (dysregulation), exacerbating adverse outcomes. Neural correlates underlying impaired self-regulat...

    Chia-Jui Tsai, Hsiang-Yuan Lin in European Archives of Psychiatry and Clinic… (2024)

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