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    Article

    Correlative metabologenomics of 110 fungi reveals metabolite–gene cluster pairs

    Natural products research increasingly applies -omics technologies to guide molecular discovery. While the combined analysis of genomic and metabolomic datasets has proved valuable for identifying natural prod...

    Lindsay K. Caesar, Fatma A. Butun, Matthew T. Robey… in Nature Chemical Biology (2023)

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    Article

    A scalable platform to identify fungal secondary metabolites and their gene clusters

    Coupling the use of artificial chromosomes with metabolomics enables the high-throughput linkage of fungal natural products with their biosynthetic gene clusters. This method was used here to identify a novel...

    Kenneth D Clevenger, ** Woo Bok, Rosa Ye, Galen P Miley… in Nature Chemical Biology (2017)

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    Article

    Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus

    Analysis of orphan nonribosomal peptide synthetase–like gene clusters from Aspergillus fumigatus identified a gene cluster responsible for the biosynthesis of fumisoquin isoquinoline alkaloids by amino acid conde...

    Joshua A Baccile, Joseph E Spraker, Henry H Le… in Nature Chemical Biology (2016)

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    Chapter

    2 Insight into Fungal Secondary Metabolism from Ten Years of LaeA Research

    In 2004, the protein LaeA was identified and characterized as a global regulator of secondary metabolism in the fungus Aspergillus nidulans. Since this initial report, LaeA has been further described as a member ...

    ** Woo Bok, Nancy P. Keller in Biochemistry and Molecular Biology (2016)

  5. Article

    Correction: Corrigendum: Chromatin-level regulation of biosynthetic gene clusters

    Nat. Chem. Biol. 5, 462–464 (2009); published online 17 May 2009; corrected after print 18 August 2009 In the version of this article initially published, the fourth author's last name is misspelled. The autho...

    ** Woo Bok, Yi-Ming Chiang, Edyta Szewczyk… in Nature Chemical Biology (2009)

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    Article

    Chromatin-level regulation of biosynthetic gene clusters

    ** Woo Bok, Yi-Ming Chiang, Edyta Szewczyk… in Nature Chemical Biology (2009)

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    Article

    Kalilo plasmids are a family of four distinct members with individual global distributions across species

    Kalilo is a linear 9-kb plasmid, isolated originally from Hawaiian strains of the heterothallic fungus Neurospora intermedia. Its properties include terminal inverted repeats, two ORFs coding for a presumptive D...

    Cynthia He, Nastasja de Groot, ** Woo Bok, Anthony J.F. Griffiths in Current Genetics (2000)

  8. No Access

    Article

    Transfer of Neurospora kalilo plasmids among species and strains by introgression

    There are four different variants of the kalilo “family” of linear mitochondrial plasmids. This family is found in several heterothallic species and one pseudohomothallic species of Neurospora, as well as in one...

    **-Woo Bok, Cynthia He, Anthony J. F. Griffiths in Current Genetics (1999)