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Article
Chromatin-level regulation of biosynthetic gene clusters
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Article
Correction: Corrigendum: Chromatin-level regulation of biosynthetic gene clusters
Nat. Chem. Biol. 5, 462–464 (2009); published online 17 May 2009; corrected after print 18 August 2009 In the version of this article initially published, the fourth author's last name is misspelled. The autho...
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Article
Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus
Analysis of orphan nonribosomal peptide synthetase–like gene clusters from Aspergillus fumigatus identified a gene cluster responsible for the biosynthesis of fumisoquin isoquinoline alkaloids by amino acid conde...
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Article
A scalable platform to identify fungal secondary metabolites and their gene clusters
Coupling the use of artificial chromosomes with metabolomics enables the high-throughput linkage of fungal natural products with their biosynthetic gene clusters. This method was used here to identify a novel...
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Article
Correlative metabologenomics of 110 fungi reveals metabolite–gene cluster pairs
Natural products research increasingly applies -omics technologies to guide molecular discovery. While the combined analysis of genomic and metabolomic datasets has proved valuable for identifying natural prod...