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Article
Vascular endothelial growth factor enhances axonal outgrowth in organotypic spinal cord slices via vascular endothelial growth factor receptor 1 and 2
Enhancing adult nerve regeneration is a potential therapeutic strategy for treating spinal cord injury. Vascular endothelial growth factor (VEGF) is a major contributor to angiogenesis, which can reduce the sp...
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Article
Ankyrin repeat-rich membrane spanning/Kidins220 protein interacts with mammalian Septin 5
Neurotrophin receptors utilize specific adaptor proteins to activate signaling pathways involved in various neuronal functions, such as neurite outgrowth and cytoskeletal remodeling. The Ankyrin-Repeat Rich Me...
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Article
Open AccessA versatile approach to multiple gene RNA interference using microRNA-based short hairpin RNAs
Effective and stable knockdown of multiple gene targets by RNA interference is often necessary to overcome isoform redundancy, but it remains a technical challenge when working with intractable cell systems.
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Article
Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy
RNA interference (RNAi) is the process of sequence-specific post-transcriptional gene silencing triggered by double-stranded RNAs1,2,3. In attempts to identify RNAi triggers that effectively function at lower con...
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Chapter
Enhancing RNAi with Synthetic RNA Duplexes
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Article
The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC–Cdc20 complex
The tumour suppressor gene RASSF1A is frequently silenced in lung cancer and other sporadic tumours as a result of hypermethylation of a CpG island in its promoter1,2,3,4,5,6. However, the precise mechanism by wh...