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Article
Evaluation of Paste-Type Micronized Acellular Dermal Matrix for Soft Tissue Augmentation: Volumetric and Histological Assessment in a Mouse Model
A biological injectable material, paste-type micronized acellular dermal matrix (ADM), has been proven effective in wound healing by filling defects through tissue replacement. This study aimed to compare the ...
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Thoracodorsal Artery Perforator Flap
The conventional latissimus dorsi muscle or myocutaneous flap is a workhorse flap that has been used consistently for a long time, and various techniques and clinical results have been reported in numerous lit...
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Article
Open AccessInduction of Nanog in neural progenitor cells for adaptive regeneration of ischemic brain
NANOG plays a key role in cellular plasticity and the acquisition of the stem cell state during reprogramming, but its role in the regenerative process remains unclear. Here, we show that the induction of NANO...
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Article
Association Between Carotid Ultrasonography Findings and Colorectal Adenoma in Asymptomatic Adults
Coexistence of colorectal neoplasia and atherosclerotic cardiovascular disease has been reported. Subclinical atherosclerosis can be evaluated noninvasively and easily by assessing carotid intima–media thickne...
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Article
Glia-Like Cells from Late-Passage Human MSCs Protect Against Ischemic Stroke Through IGFBP-4
Stem cell therapy is considered to be a promising future treatment for intractable neurological diseases, although all the clinical trials using stem cells have not yet shown any good results. Early passage me...
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Article
Open AccessSmall molecule-based lineage switch of human adipose-derived stem cells into neural stem cells and functional GABAergic neurons
Cellular reprogramming using small molecules (SMs) without genetic modification provides a promising strategy for generating target cells for cell-based therapy. Human adipose-derived stem cells (hADSCs) are a...
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Article
Treatment outcomes and recurrence following standard cold forceps polypectomy for diminutive polyps
The recurrence rate after standard cold forceps polypectomy (CFP) of diminutive polyps of ≤5 mm has not been fully determined. The aim of this study was to analyze the long-term follow...
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Article
Prediction of the Risk of a Metachronous Advanced Colorectal Neoplasm Using a Novel Scoring System
This study aimed to develop and validate a risk score model to estimate the probability of a metachronous advanced colorectal neoplasm (ACRN) at surveillance colonoscopy.
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Article
Vascular endothelial growth factor enhances axonal outgrowth in organotypic spinal cord slices via vascular endothelial growth factor receptor 1 and 2
Enhancing adult nerve regeneration is a potential therapeutic strategy for treating spinal cord injury. Vascular endothelial growth factor (VEGF) is a major contributor to angiogenesis, which can reduce the sp...
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Article
Probability of High-Risk Colorectal Neoplasm Recurrence Based on the Results of Two Previous Colonoscopies
Current guidelines for the surveillance colonoscopy interval are largely based on the most recent colonoscopy findings.
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Article
Open AccessMolecular epidemiology of canine GM1 gangliosidosis in the Shiba Inu breed in Japan: relationship between regional prevalence and carrier frequency
Canine GM1 gangliosidosis is a fatal disease in the Shiba Inu breed, which is one of the most popular traditional breeds in Japan and is maintained as a standard breed in many countries. Therefore, it is impor...
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Dihydropyrimidinase Deficiency: The First Feline Case of Dihydropyrimidinuria with Clinical and Molecular Findings
Dihydropyrimidinase (DHP, EC 3.5.2.2) is the second enzyme of the pyrimidine degradation pathway and a deficiency of this enzyme is responsible for a rare inborn metabolic syndrome characterized by dihydropyri...
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Article
Ankyrin repeat-rich membrane spanning/Kidins220 protein interacts with mammalian Septin 5
Neurotrophin receptors utilize specific adaptor proteins to activate signaling pathways involved in various neuronal functions, such as neurite outgrowth and cytoskeletal remodeling. The Ankyrin-Repeat Rich Me...
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Article
Open AccessA versatile approach to multiple gene RNA interference using microRNA-based short hairpin RNAs
Effective and stable knockdown of multiple gene targets by RNA interference is often necessary to overcome isoform redundancy, but it remains a technical challenge when working with intractable cell systems.
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Effect of quercitrin gallate on zymosan A-lnduced peroxynitrite production in macrophages
We previously isolated quercetin 3-O-β-(2#x2033;-galloyl)-rhamnopyranoside (QGR), a quercitrin gallate, from aerial parts ofPersicaria lapathifolia (Polygonaceae) to prevent Superoxide production in monocytes fro...
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Article
Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy
RNA interference (RNAi) is the process of sequence-specific post-transcriptional gene silencing triggered by double-stranded RNAs1,2,3. In attempts to identify RNAi triggers that effectively function at lower con...
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Enhancing RNAi with Synthetic RNA Duplexes
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Article
Functional Constipation With Impaired Rectal Sensation Improved by Electrical Stimulation Therapy: Report of a Case
Patients with intractable constipation often complain of social, physical, and psychologic stress. Recently, biofeedback therapy has been widely used for the management of intractable constipation, particularl...
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Article
The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC–Cdc20 complex
The tumour suppressor gene RASSF1A is frequently silenced in lung cancer and other sporadic tumours as a result of hypermethylation of a CpG island in its promoter1,2,3,4,5,6. However, the precise mechanism by wh...
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Article
Effect of electrical stimulation in constipated patients with impaired rectal sensation
A subgroup of constipated patients complain of absent or diminished sense of wanting to defecate, suggesting that one of the causes of constipation is impaired rectal sensation. Electrical stimulation therapy ...
