350 Result(s)

Article

Vacor inhibits insulin release from islets in vitro

It has been reported that Vacor, a rodenticide containing N-3-pyridylmethyl-N’-p-nitrophenyl urea, causes insulin-dependent diabetes mellitus. The pathomechanism of Vacor-induced diabetes mellitus has not been...

H. Taniguchi M.D., Ph.D., Y. Yamashiro… in Journal of Endocrinological Investigation (1989)

Article

Cross-reactive antibodies in the serum of balb/c mice immunized with thyroid or eye muscle membranes

During the course of immunizing balb/c mice with eye muscle (EM) or thyroid (THY) membranes for monoclonal antibody (MCAB) production their sera frequently contain antibodies which react against both EM and TH...

J. R. Wall M.D., H. Triller, F. Chung, M. Tsao… in Journal of Endocrinological Investigation (1994)

Article

Esophageal aspergillosis after bone marrow transplant

The prolonged immune suppression associated with bone marrow transplants predisposes to fungal infections including Aspergillus. Disseminated aspergillosis occurs in up to 60% of patients with invasive pulmonary ...

JH Choi, JH Yoo, IJ Chung, DW Kim, CW Han, WS Shin, WS Min… in Bone Marrow Transplantation (1997)

Article

A novel human ERK phosphatase regulates H-ras and v-raf signal transduction

A cDNA encoding a novel human extracellularly-regulated kinase (ERK) phosphatase, designated B59, was isolated from a B5/589 human mammary epithelial cell cDNA library. The 1104 nucleotide open reading frame e...

Deug-Yong Shin, Toshio Ishibashi, Tae Sang Choi, Eunmi Chung, Il Yup Chung… in Oncogene (1997)

Article

Evidence of genetic progression in human gastric carcinomas with microsatellite instability

Mutator phenotype tumors provide unique opportunities to unravel malignant progression because of various gene alterations acquired during clonal tumor evolution. Gastric carcinomas, which have been known to s...

Yeun-Jun Chung, Sang-Won Park, Ji-Min Song, Kyo-Young Lee, Eun-Joo Seo… in Oncogene (1997)

Article

Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells

We have previously reported that ursolic acid, a pentacyclic triterpene acid, inhibited the invasion of HT1080 human fibrosarcoma cells by reducing the expression of matrix metalloproteinase-9. Since the chemi...

Hee-Jae Cha, Moon-Taek Park, Hae-Young Chung, Nam Deuk Kim, Hiroshi Sato… in Oncogene (1998)

Article

Life-threatening carboplatin hypersensitivity during conditioning for autologous PBSC transplantation: successful rechallenge after desensitization

Carboplatin hypersensitivity has rarely been reported in patients receiving repeated cycles of therapy, but has not been reported in transplant settings. We report a case of carboplatin hypersensitivity during...

H Kook, KM Kim, SH Choi, BS Choi, HJ Kim, SY Chung, SJN Choi… in Bone Marrow Transplantation (1998)

Article

Radioresistant MTp53-expressing rat embryo cell transformants exhibit increased DNA-dsb rejoining during exposure to ionizing radiation

Recent data suggest that aberrant function of the wild type p53 protein (WTp53) may alter cellular survival following DNA damage through cellular pathways involving apoptosis and cell-cycle checkpoints, but li...

Robert G Bristow, Qiyue Hu, Anne Jang, Stephen Chung, James Peacock… in Oncogene (1998)

Article

A cell surface molecule, JL1; a specific target for diagnosis and treatment of leukemias

We previously reported a novel differentiation antigen, which is specifically expressed in stage II double positive (CD4⁺CD8⁺) human cortical thymocytes (Park et al, J Exp Med 1993; 178: 1447–1451). This study wa...

WS Park, YM Bae, DH Chung, TJ Kim, EY Choi, J-K Chung, MC Lee, SY Park, MH Park… in Leukemia (1998)

Article

PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate

Deletion of the q23-24 region of human chromosome 10 is one of the most frequent genetic alterations in prostate cancer, suggesting that inactivation of a tumor suppressor gene in this region is involved in th...

**-Tang Dong, Tavis W Sipe, Eija-Riitta Hyytinen, Chang-Ling Li… in Oncogene (1998)

Article

Homozygous deletions at 3p12 in breast and lung cancer

We have constructed a physical map of the region homozygously deleted in the U2020 cell line at 3p12, including the location of putative CpG islands. Adjacent to one of these islands, we have identified and cl...

Vasi Sundaresan, Grace Chung, Amanda Heppell-Parton, J **ong, Catherine Grundy… in Oncogene (1998)

Article

Fractional allelic loss in gastric carcinoma correlates with growth patterns

To gain an insight into the genetic events underlying morphological phenotypes, we analysed 58 gastric carcinoma tissues for the genome-wide allelotype study using microsatellite markers. Based on a binomial d...

Sang-Wook Choi, Sang-Won Park, Kyo-Young Lee, Kyoung-Mee Kim, Yeun-Jun Chung… in Oncogene (1998)

Article

Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells

Manganese superoxide dismutase (MnSOD) has been shown to play an important role in preventing the development of cancer. MnSOD activity is reduced in many transformed cells and tumor tissues. We previously sho...

Yong Xu, Anuradha Krishnan, X Steven Wan, Hideyuki Majima, Che-Chung Yeh… in Oncogene (1999)

Article

Linkages and associations between the leptin receptor (LEPR) gene and human body composition in the Québec Family Study

OBJECTIVE: To investigate linkage and association between the leptin receptor (LEPR) gene and body composition variables in the Québec Family Study (QFS).

YC Chagnon, WK Chung, L Pérusse, M Chagnon, RL Leibel… in International Journal of Obesity (1999)

Article

Synergistic effects of retinoic acid and 8-Cl-cAMP on apoptosis require caspase-3 activation in human ovarian cancer cells

We investigated the intracellular mechanisms of retinoic acid (9-cis-RA, 13-cis-RA or all-trans-RA) and a cyclic AMP analog 8-Cl-cAMP on growth-inhibition and apoptosis in human ovarian cancer NIH: OVCAR-3 and...

Rakesh K Srivastava, Aparna R Srivastava, Yoon S Cho-Chung, Dan L Longo in Oncogene (1999)

Article

The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis

The biological role(s) proposed for UCP3 in energy homeostasis have been based primarily upon amino acid sequence homology to UCP1. Spontaneous mutations of UCP3 have been described in humans, but not in roden...

WK Chung, A Luke, RS Cooper, C Rotini, A Vidal-Puig… in International Journal of Obesity (1999)

Article

Telomere length changes in patients undergoing hematopoietic stem cell transplantation

Telomere length indicates the replicative history of cells, serving as a molecular measure of the replicative potential remaining in cells. To investigate telomere length changes in hematopoietic stem cells, p...

JJ Lee, H Kook, IJ Chung, HJ Kim, MR Park, CJ Kim, JA Nah… in Bone Marrow Transplantation (1999)

Article

Protein kinase A-Iα subunit-directed antisense inhibition of ovarian cancer cell growth: crosstalk with tyrosine kinase signaling pathway

Expression of the RIα subunit of cAMP-dependent protein kinase type I is increased in human cancers in which an autocrine pathway for epidermal growth factor-related growth factors is activated. We have invest...

Özge Alper, Neville F Hacker, Yoon S Cho-Chung in Oncogene (1999)

Article

Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); A novel nuclear target of Akt

Akt is stimulated by several growth factors, and mediates their cell survival signals. Recent studies have shown that Akt may play an intermediate role between phosphatidylinositol 3-kinase (PI3K) and p70 S6 k...

Hyongjong Koh, Kwangho Jee, Bona Lee, Jeonghoon Kim, Dohoon Kim, Young-Ha Yun… in Oncogene (1999)

Article

Life-threatening paroxysmal supraventricular tachycardia developed during granulocyte transfusion therapy for neutropenia-related infection

J-J Lee, I-J Chung, Y-K Ahn, M-R Park, D-H Shin, J-G Cho, H-J Kim in Leukemia (2000)