830 Result(s)
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Article
Fatal basilar artery occlusion following cervical spine injury
A patient rendered acutely quadriplegic in an automobile accident was shown by angiography to have occlusion of the left vertebral artery. One month later, he abruptly became unconscious, apneic and died. Auto...
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Follow-up study on the use of leg braces issued to spinal cord injury patients
A letter questionnaire was sent to 250 spinal cord injury (SCI) patients with leg braces who were admitted to a VA Medical Centre from January 1978 to December 1984. There were 73 responses deemed to be comple...
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Estimation of the outcrossing rate in the chestnut blight fungus, Cryphonectria parasitica
The outcrossing rate in the chestnut blight fungus, Cryphonectria (Endothia) parasitica, was estimated in a natural population using data from six unlinked restriction fragment length polymorphism (RFLP) loci and...
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Antidiuretic hormone levels and polyuria in spinal cord injury. A preliminary report
Chronic cervical spinal cord injury is characterized by defects in sodium and water homeostasis and defects of adaptive hormonal responses. The plasma osmolality is maintained in a relatively narrow range, the...
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Compliance and complications of clean intermittent catheterization in the spinal cord injured patient
The optimal management of the neuropathic bladder secondary to spinal cord injury remains unsettled. Some have advocated the use of chronic indwelling catheters in tetraplegic patients supposedly due to compar...
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Open AccessHigh-does nitric oxide induces apoptosis in HL-60 human myeloid leukemia cells
The treatment of human promyeloid leukemia cell line HL-60 cells with nitric oxide (NO) is associated with loss of proliferative apacity and induction of monocytic differentiation. The present results demonstr...
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Open AccessCircumvention of drug resistance in cancer cells by a new fluoropyrimidine analogue
The potentiation of antitumor drugs by their analogues is one of strategies for overcoming cellular resistance to chemotherapy. In attempts to improve the efficacy of 5-fluorouracil (5-FU) and overcome 5-FU re...
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Open AccessAn enzyme immunoassay for pregnancy-specific β-1 glycoprotein (SP1), employing monoclonal antibodies
Two-site binding enzyme immunoassay for pregnancy-specific -β1 glycoprotein (SP1) has been developed using two monoclonal antibodies which can recognize all the three forms of SP1 from human sera. This assay s...
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Open AccessRetroviral-mediated IL-12 gene therapy for advanced murine tumors
Interleukin 12 (IL-12), a heterodimeric cytokine, promotes an effective antitumor response against tumors of various histological types when delivered systemically as a protein or locally by gene transfer. We ...
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Open AccessProduction and characterization of monoclonal antibodies to oxidized LDL
Oxidized low density lipoprotein (LDL) seems to take a part in atherogenesis through direct interactions with macrophages, endothelial cells, and smooth muscle cells, and is thought to participate in renal glo...
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Open AccessEffect of petroleum ether extract of Panax ginseng roots on proliferation and cell cycle progression of human renal cell carcinoma cells
Panax ginseng roots have long been used as a medicinal herb in oriental countries. We have investigated anti-proliferative effects of lipid soluble Panax ginseng components on human renal cancer cell lines. Pe...
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Open AccessSuppression of multidrug resistance via inhibition of heat shock factor by quercetin in MDR cells
MDR1 promoter has been shown to contain heat shock elements (HSE), and it has been reported that FM3A/M and P388/M MDR cells show a constitutively activated heat shock factor (HSF), suggesting that HSF might b...
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Correction: A mouse model of Greig cephalapolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene
Nature Genet. 3, 241– 246 (1993). Originally, we reported that the 3′ end of Gli3 is not deleted in the XtJ allele (Fig. 4). U. Rüther brought to our attention that the XtJ allele indeed contains a deletion in...
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Article
Open AccessA variant of ornithine aminotransferase from mouse small intestine
The ornithine aminotransferase (OAT) activity of mouse was found to be highest in the small intestine. The mitochondrial OAT from mouse small intestine was purified to homogeneity by the procedures including h...
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Open AccessCalyculin A modulates activation of the NADPH-oxidase in Me2SO-differentiated HL-60 cells
Human promyelocytic leukemia cells (HL-60) have been used as a model system in which to study the effects of protein phosphatase inhibitors on NADPH-oxidase activation. Since O2- is generated by NADPH-oxidase,...
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Open AccessMicrosatellite instability, Epstein–Barr virus, mutation of type II transforming growth factor β receptor and BAX in gastric carcinomas in Hong Kong Chinese
Microsatellite instability (MI), the phenotypic manifestation of mismatch repair failure, is found in a proportion of gastric carcinomas. Little is known of the links between MI and Epstein–Barr virus (EBV) st...
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Open AccessRole of Ras/ERK-dependent pathway in the erythroid differentiation of K562 cells
The chronic myelogenous leukemic K562 cell line carrying Bcr-Abl tyrosine kinase is considered as pluripotent hematopoietic progenitor cells expressing markers for erythroid, granulocytic, monocytic, and megak...
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Article
Open AccessDevelopment of two novel nontoxic mutants of Escherichia coli heat-labile enterotoxin
Escherichia coli heat-labile enterotoxin (LT) is composed of catalytic A and non-catalytic homo-pentameric B subunits and causes diarrheal disease in human and animals. In order to produce a nontoxic LT for va...
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Open AccessPrenatal detection of de novo inversion of chromosome 9 with duplicated heterochromatic region and postnatal follow-up
We report the first de novo case of a heterochromatic duplication on the long arm of the chromosome 9, which then was pericentrically inverted at p11q13. This condition was detected prenatally and carry to ter...
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Open AccessInhibiting tumorigenic potential by restoration of p16 in nasopharyngeal carcinoma
The p16 gene, encodes a key checkpoint protein p16 in the cell cycle, has been reported inactivation in a wide variety of human cancers. We have previously demonstrated high frequency of p16 alterations in primar...
