82 Result(s)
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English
Biomedicine
Biomedicine, general
Pharmacology/Toxicology
** Chung
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Article
Evaluation of neurological behavior alterations and metabolic changes in mice under chronic glyphosate exposure
Glyphosate is a widely used active ingredient in agricultural herbicides, inhibiting the biosynthesis of aromatic amino acids in plants by targeting their shikimate pathway. Our gut microbiota also facilitates...
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Pretreatment of rhesus monkeys with transdermal patches containing physostigmine and procyclidine: implications of the delivery system for the potential application against VX nerve agent intoxication in humans
Physostigmine (Phs) is a reversible inhibitor of acetylcholinesterase (AChE) that penetrates the blood–brain barrier (BBB) and could be used to protect the central nervous system (CNS) against the effects of n...
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Low-dose tributyltin triggers human chondrocyte senescence and mouse articular cartilage aging
Tributyltin (TBT) is known as an endocrine-disrupting chemical. This study investigated the effects and possible mechanisms of TBT exposure on inducing human articular chondrocyte senescence in vitro at the hu...
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An artificial intelligence approach for predicting cardiotoxicity in breast cancer patients receiving anthracycline
Although anti-cancer therapy-induced cardiotoxicity is known, until now it lacks a reliable risk predictive model of the subsequent cardiotoxicity in breast cancer patients receiving anthracycline therapy. An ...
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Relationships of multiple metals exposure, global DNA methylation, and urothelial carcinoma in central Taiwan
The relationship between heavy metal exposure and human health has been investigated mostly for individual metals, failing to consider their potential interactions. In this study, we assessed the joint effects...
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Open AccessBerberine alleviates visceral hypersensitivity in rats by altering gut microbiome and suppressing spinal microglial activation
Accumulating evidence shows that agents targeting gut dysbiosis are effective for improving symptoms of irritable bowel syndrome (IBS). However, the potential mechanisms remain unclear. In this study we invest...
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3,4-dihydroxytoluene, a metabolite of rutin, suppresses the progression of nonalcoholic fatty liver disease in mice by inhibiting p300 histone acetyltransferase activity
3,3′,4′,5,7-Pentahydroxyflavone-3-rhamnoglucoside (rutin) is a flavonoid with a wide range of pharmacological activities. Dietary rutin is hardly absorbed because the microflora in the large intestine metaboli...
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Open AccessNew insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids
5-Fluorouracil (5-FU) is a widely used chemotherapeutical that induces acute toxicity in the small and large intestine of patients. Symptoms can be severe and lead to the interruption of cancer treatments. How...
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L-Carnitine protects against tacrolimus-induced renal injury by attenuating programmed cell death via PI3K/AKT/PTEN signaling
Reducing immunosuppressant-related complications using conventional drugs is an efficient therapeutic strategy. L-carnitine (LC) has been shown to protect against various types of renal injury. In this study, we ...
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Article
ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma
Sorafenib is the first-line treatment of advanced hepatocellular carcinoma (HCC). However, there is a lack of validated biomarkers to predict sorafenib sensitivity. In this study we investigated the role of AC...
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Combined effect of polymorphisms of MTHFR and MTR and arsenic methylation capacity on developmental delay in preschool children in Taiwan
Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR) are related to cognitive dysfunction and mental disability. These genes, along with folate and vitamin B12 levels, are re...
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Arsenic induces human chondrocyte senescence and accelerates rat articular cartilage aging
Arsenic-contaminated drinking water is known to be a serious human health problem. A previous epidemiological study has indicated that arsenic levels in blood were higher in arthritis patients compared to age-...
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Association of plasma folate, vitamin B12 levels, and arsenic methylation capacity with developmental delay in preschool children in Taiwan
Developmental delay has been associated with inefficient arsenic methylation capacity in preschool children. Folate and vitamin B12 are important nutrients that produce s-adenosylmethionine during single-carbo...
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Measurement of urinary arsenic profiles and DNA hypomethylation in a case–control study of urothelial carcinoma
Environmental exposure to arsenic may be involved in the disturbance of DNA hypomethylation. The aim of this study is the first to explore the effect of interactions of urinary total arsenic levels, arsenic m...
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Effects of antiepileptic drugs on lipogenic gene regulation and hyperlipidemia risk in Taiwan: a nationwide population-based cohort study and supporting in vitro studies
To characterize the association between epilepsy, use of antiepileptic drugs (AEDs), and the risk of hyperlipidemia, we conducted a nationwide population-based cohort study with data obtained from the National...
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Paradoxical lack of increase in endothelin-1 levels in obese mice – possible role of endothelin-B receptors
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Article
Cancer Chemoprevention: What Have we Learned?
Cancer is a major disease worldwide and different approaches are needed to reduce its risk. Previous laboratory studies suggested that cancer can be prevented by many naturally occurring and synthetic chemical...
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The novel resveratrol derivative 3,5-diethoxy-3′,4′-dihydroxy-trans-stilbene induces mitochondrial ROS-mediated ER stress and cell death in human hepatoma cells in vitro
Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a well-known polyphenol that is present in grapes, peanuts, pine seeds, and several other plants. Resveratrol exerts deleterious effects on various types of human...
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Endothelial overexpression of endothelin-1 modulates aortic, carotid, iliac and renal arterial responses in obese mice
Endothelin-1 (ET-1) is essential for mammalian development and life, but it has also been implicated in increased cardiovascular risk under pathophysiological conditions. The aim of this study was to determine...
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Absorption mechanism of DHP107, an oral paclitaxel formulation that forms a hydrated lipidic sponge phase
Paclitaxel is a most widely used anticancer drug with low oral bioavailability, thus it is currently administered via intravenous infusion. DHP107 is a lipid-based paclitaxel formulation that can be administer...
